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• W4311411321 abstract "<ns4:p><ns4:bold>Background</ns4:bold>: Acute lymphoblastic leukaemia (ALL) is the most common type of cancer in children. General anaesthetics are often used on patients undergoing painful procedures during ALL treatments but their effects on ALL malignancy remain unknown. Herein, we aim to study the effect of two commonly used general anaesthetics, intravenous propofol and inhalational sevoflurane, on the migration and homing of ALL cells <ns4:italic>in vitro</ns4:italic> and <ns4:italic>in vivo</ns4:italic>.</ns4:p><ns4:p> <ns4:bold>Methods</ns4:bold>: NALM-6 cells were treated with propofol (5 and 10 μg/ml) or sevoflurane (3.6%) <ns4:italic>in vitro </ns4:italic>for six hours. Then, cells were harvested for flow cytometry analysis. For <ns4:italic>in vitro </ns4:italic>migration experiments, NALM-6 cells were pre-treated with propofol and sevoflurane for six hours before being loaded onto the upper chamber of a migration chamber and cells were collected in the lower chamber after six hours of migration. For <ns4:italic>in vivo </ns4:italic>adhesion assays, NALM-6 cells were pre-treated with propofol and sevoflurane before an adhesion assay was carried out. In <ns4:italic>in vitro </ns4:italic>experiments, GFP-NALM-6 cells were pre-treated with propofol (10 μg/ml) or sevoflurane (3.6%) for six hours. Then, cells were injected intravenously to C57BL/6 female mice followed by intravital microscopy.</ns4:p><ns4:p> <ns4:bold>Results</ns4:bold>: Both anaesthetics reduced <ns4:italic>in vitro </ns4:italic>migration, <ns4:italic>in vivo</ns4:italic> migration and <ns4:italic>in vivo</ns4:italic> homing as exemplified by 1) the reduction in the number of cells entering the bone marrow and 2) the disturbance in homing location in relation to the nearest endosteal surface. Our results indicated that general anaesthetics reduced the surface CXCR4 expression. In addition, the adhesion of leukaemia cells to thrombin cleaved osteopontin (OPN) was reduced by general anaesthetics. Those changes might result in the alterations in migration and homing.</ns4:p><ns4:p> <ns4:bold>Conclusion</ns4:bold>: Together, our data suggest that both propofol and sevoflurane could reduce ALL migration and homing <ns4:italic>in vivo</ns4:italic> and <ns4:italic>in vitro via</ns4:italic> CXCR4 and OPN mediated mechanisms.</ns4:p>" @default.
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• W4311411321 date "2022-12-12" @default.
• W4311411321 modified "2023-09-24" @default.
• W4311411321 title "General anaesthetics reduce acute lymphoblastic leukaemia cell migration and homing in vitro and in vivo via CXCR4 and osteopontin mediated mechanisms" @default.
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• W4311411321 doi "https://doi.org/10.12688/f1000research.125877.1" @default.
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