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- W4311421738 abstract "Since their discovery, the Hox genes, with their incredible power to reprogram the identity of complete body regions, a phenomenon called homeosis, have captured the fascination of many biologists. Recent research has provided new insights into the function of Hox proteins in different germ layers and the mechanisms they employ to control tissue morphogenesis. We focus in this review on the ectoderm and mesoderm to highlight new findings and discuss them with regards to established concepts of Hox target gene regulation. Furthermore, we highlight the molecular mechanisms involved the transcriptional repression of specific groups of Hox target genes, and summarize the role of Hox mediated gene silencing in tissue development. Finally, we reflect on recent findings identifying a large number of tissue-specific Hox interactor partners, which open up new avenues and directions towards a better understanding of Hox function and specificity in different tissues." @default.
- W4311421738 created "2022-12-26" @default.
- W4311421738 creator A5007807407 @default.
- W4311421738 creator A5016457100 @default.
- W4311421738 creator A5070071356 @default.
- W4311421738 date "2024-01-01" @default.
- W4311421738 modified "2023-09-26" @default.
- W4311421738 title "Hox function and specificity – A tissue centric view" @default.
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- W4311421738 doi "https://doi.org/10.1016/j.semcdb.2022.11.011" @default.
- W4311421738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36517344" @default.
- W4311421738 hasPublicationYear "2024" @default.
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