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• W4311422480 abstract "Lead (Pb) is a heavy metal that alters the oxidation-reduction balance, affecting reproductive health and transfer during pregnancy and lactation. However, the multigenerational impact of exposure to low concentrations of Pb on mammalian ovaries has not been assessed. This study evaluated general parameters, histology, redox state (RS), protein carbonylation (PC), lipid peroxidation (LP), and hormone concentrations in the ovaries of mice (CD1® ICR) of three successive generations with both unigenerational (E1) and multigenerational (E2) exposure to 0.2 ppm lead acetate through the drinking water and a control group. Body weight, food consumption, the number of born pups, and their weight after weaning were not significantly affected by Pb exposure in E1 and E2. However, the ovaries of three successive generations of the E1 group, in which only the F0 was exposed, showed alterations in the ovarian histoarchitecture, increase in follicular atresia, decrease in the number of available follicles, and a significant RS and PC elevation that were surprisingly similar to those observed in the E2 group. LP increased in the second generation of E1 and E2, while hormone concentration was not altered. This is the first demonstration that exposure to low concentration of Pb induces multigenerational histological alterations and oxidative stress in mouse ovaries, that the termination of this exposure does not ensure the safety of later generations and that the lack of modifications in general parameters may facilitate the silent development of pathologies that affect ovarian health." @default.
• W4311422480 created "2022-12-26" @default.
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• W4311422480 date "2023-01-01" @default.
• W4311422480 modified "2023-10-03" @default.
• W4311422480 title "Oxidative stress in the ovaries of mice chronically exposed to a low lead concentration: A generational approach" @default.
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• W4311422480 doi "https://doi.org/10.1016/j.reprotox.2022.12.001" @default.
• W4311422480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36473649" @default.
• W4311422480 hasPublicationYear "2023" @default.
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