Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311431186> ?p ?o ?g. }
- W4311431186 endingPage "104560" @default.
- W4311431186 startingPage "104560" @default.
- W4311431186 abstract "The rate of neurodegenerative diseases such as Alzheimer's disease (AD) is rising, particularly in older people. Several medicines are available to temporarily ameliorate the signs of AD but due to adverse effects and inadequate efficacy, there is a need to search for new compounds. Zingiber officinale Roscoe (ginger) is well known for its abundant valuable medicinal properties which might be suitable for the treatment and management of AD. The extracted essential ginger oils from eight samples of Z. officinale from different locations of Senapati district, Manipur were aimed to identify the oil constituents and evaluate the acetylcholinesterase (AChE) inhibitory activity. All the ginger oils were standardized and the major compound (α-citral) was quantified in each oil. Six major volatile compounds (common in all the oils) were further studied through molecular docking analysis to evaluate the possible binding interaction profile with the acetylcholinesterase (AChE) enzyme. Gas chromatography-mass spectrometry (GC-MS) analysis of oils revealed that α-citral is the most abundant chemical constituent in all ginger oils ranging from 13.92 to 30.46%. α-citral, camphene, geraniol, α-pinene, linalool, and α-citronellol were commonly present in all eight ginger oils. Sample M1 showed the highest activity (IC50 = 51.12 ± 0.37 μg/ml; ***P < 0.001) while the lowest activity was observed in Sample M7 (IC50 = 84.47 ± 0.29 μg/ml; ***P < 0.001) against AChE activity. The AChE inhibition activity of chemical constituents was decreased in the following order: linalool > camphene > α-citronellol > α-citral > geraniol > α-pinene. The percentage of marker compound (α-citral) in ginger oil was found maximum in sample M1 (243.9 ± 3.1 μg/mg) and minimum in sample M5 (111.33 ± 1.5 μg/mg). It was observed that all six chemical compounds perfectly occupied the biologically relevant several subsites region, such as the oxyanion hole, anionic subsite binding pocket, or peripheral anionic site (PAS) of the AChE protein. Our results highlight the chemo diversity of ginger available in Manipur and its importance as a potential AChE inhibitor." @default.
- W4311431186 created "2022-12-26" @default.
- W4311431186 creator A5004226919 @default.
- W4311431186 creator A5006304134 @default.
- W4311431186 creator A5007698663 @default.
- W4311431186 creator A5010585679 @default.
- W4311431186 creator A5016684500 @default.
- W4311431186 creator A5031425819 @default.
- W4311431186 creator A5032009896 @default.
- W4311431186 creator A5041859640 @default.
- W4311431186 creator A5046172723 @default.
- W4311431186 creator A5058681699 @default.
- W4311431186 creator A5062068011 @default.
- W4311431186 creator A5074310876 @default.
- W4311431186 date "2023-02-01" @default.
- W4311431186 modified "2023-10-16" @default.
- W4311431186 title "Chemo diversity of ginger-a potent crop in Manipur and its acetylcholinesterase (AChE) inhibitory potential" @default.
- W4311431186 cites W1195522429 @default.
- W4311431186 cites W1603982824 @default.
- W4311431186 cites W1971048984 @default.
- W4311431186 cites W1988158524 @default.
- W4311431186 cites W2023551843 @default.
- W4311431186 cites W2025816743 @default.
- W4311431186 cites W2056893921 @default.
- W4311431186 cites W2057223740 @default.
- W4311431186 cites W2060288971 @default.
- W4311431186 cites W2061201354 @default.
- W4311431186 cites W2061863044 @default.
- W4311431186 cites W2062797062 @default.
- W4311431186 cites W2077569538 @default.
- W4311431186 cites W2078301842 @default.
- W4311431186 cites W2118689130 @default.
- W4311431186 cites W2128190798 @default.
- W4311431186 cites W2130479394 @default.
- W4311431186 cites W2148843380 @default.
- W4311431186 cites W2157922050 @default.
- W4311431186 cites W2169678694 @default.
- W4311431186 cites W2177317049 @default.
- W4311431186 cites W2236195079 @default.
- W4311431186 cites W2765679006 @default.
- W4311431186 cites W2889171080 @default.
- W4311431186 cites W2922094371 @default.
- W4311431186 cites W2966366045 @default.
- W4311431186 cites W2997160604 @default.
- W4311431186 cites W3014320516 @default.
- W4311431186 cites W3032227559 @default.
- W4311431186 cites W3095642908 @default.
- W4311431186 cites W3111976617 @default.
- W4311431186 cites W4283662359 @default.
- W4311431186 cites W4288048902 @default.
- W4311431186 doi "https://doi.org/10.1016/j.bse.2022.104560" @default.
- W4311431186 hasPublicationYear "2023" @default.
- W4311431186 type Work @default.
- W4311431186 citedByCount "0" @default.
- W4311431186 crossrefType "journal-article" @default.
- W4311431186 hasAuthorship W4311431186A5004226919 @default.
- W4311431186 hasAuthorship W4311431186A5006304134 @default.
- W4311431186 hasAuthorship W4311431186A5007698663 @default.
- W4311431186 hasAuthorship W4311431186A5010585679 @default.
- W4311431186 hasAuthorship W4311431186A5016684500 @default.
- W4311431186 hasAuthorship W4311431186A5031425819 @default.
- W4311431186 hasAuthorship W4311431186A5032009896 @default.
- W4311431186 hasAuthorship W4311431186A5041859640 @default.
- W4311431186 hasAuthorship W4311431186A5046172723 @default.
- W4311431186 hasAuthorship W4311431186A5058681699 @default.
- W4311431186 hasAuthorship W4311431186A5062068011 @default.
- W4311431186 hasAuthorship W4311431186A5074310876 @default.
- W4311431186 hasConcept C181199279 @default.
- W4311431186 hasConcept C185592680 @default.
- W4311431186 hasConcept C2777278459 @default.
- W4311431186 hasConcept C2778240251 @default.
- W4311431186 hasConcept C2778816929 @default.
- W4311431186 hasConcept C2779059548 @default.
- W4311431186 hasConcept C2779554281 @default.
- W4311431186 hasConcept C2779729912 @default.
- W4311431186 hasConcept C2780697445 @default.
- W4311431186 hasConcept C2780977547 @default.
- W4311431186 hasConcept C2781370763 @default.
- W4311431186 hasConcept C31903555 @default.
- W4311431186 hasConcept C44937612 @default.
- W4311431186 hasConcept C55493867 @default.
- W4311431186 hasConcept C556039675 @default.
- W4311431186 hasConcept C71924100 @default.
- W4311431186 hasConcept C86803240 @default.
- W4311431186 hasConceptScore W4311431186C181199279 @default.
- W4311431186 hasConceptScore W4311431186C185592680 @default.
- W4311431186 hasConceptScore W4311431186C2777278459 @default.
- W4311431186 hasConceptScore W4311431186C2778240251 @default.
- W4311431186 hasConceptScore W4311431186C2778816929 @default.
- W4311431186 hasConceptScore W4311431186C2779059548 @default.
- W4311431186 hasConceptScore W4311431186C2779554281 @default.
- W4311431186 hasConceptScore W4311431186C2779729912 @default.
- W4311431186 hasConceptScore W4311431186C2780697445 @default.
- W4311431186 hasConceptScore W4311431186C2780977547 @default.
- W4311431186 hasConceptScore W4311431186C2781370763 @default.
- W4311431186 hasConceptScore W4311431186C31903555 @default.
- W4311431186 hasConceptScore W4311431186C44937612 @default.
- W4311431186 hasConceptScore W4311431186C55493867 @default.