Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311441608> ?p ?o ?g. }
- W4311441608 abstract "Direct cardiac reprogramming has emerged as a promising therapeutic approach for cardiac regeneration. Full chemical reprogramming with small molecules to generate cardiomyocytes may be more amenable than genetic reprogramming for clinical applications as it avoids safety concerns associated with genetic manipulations. However, challenges remain regarding low conversion efficiency and incomplete cardiomyocyte maturation. Furthermore, the therapeutic potential of chemically induced cardiomyocytes (CiCMs) has not been investigated. Here, we report that a three-dimensional microenvironment reconstituted with decellularized heart extracellular matrix can enhance chemical reprogramming and cardiac maturation of fibroblasts to cardiomyocytes. The resultant CiCMs exhibit elevated cardiac marker expression, sarcomeric organization, and improved electrophysiological features and drug responses. We investigated the therapeutic potential of CiCMs reprogrammed in three-dimensional heart extracellular matrix in a rat model of myocardial infarction. Our platform can facilitate the use of CiCMs for regenerative medicine, disease modeling, and drug screening." @default.
- W4311441608 created "2022-12-26" @default.
- W4311441608 creator A5001180207 @default.
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- W4311441608 creator A5070455545 @default.
- W4311441608 creator A5070529360 @default.
- W4311441608 date "2022-12-14" @default.
- W4311441608 modified "2023-10-10" @default.
- W4311441608 title "Three-dimensional heart extracellular matrix enhances chemically induced direct cardiac reprogramming" @default.
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