FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311448089> ?p ?o ?g. }

• W4311448089 endingPage "821" @default.
• W4311448089 startingPage "804" @default.
• W4311448089 abstract "Owing to their central role in regulating cell signaling pathways, the phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are attractive therapeutic targets in diseases such as cancer, neurodegeneration, and immunological disorders. Until now, tool molecules for these kinases have been either limited in potency or isoform selectivity, which has hampered further investigation of biology and drug development. Herein we describe the virtual screening workflow which identified a series of thienylpyrimidines as PI5P4Kγ-selective inhibitors, as well as the medicinal chemistry optimization of this chemotype, to provide potent and selective tool molecules for further use. In vivo pharmacokinetics data are presented for exemplar tool molecules, along with an X-ray structure for ARUK2001607 (15) in complex with PI5P4Kγ, along with its selectivity data against >150 kinases and a Cerep safety panel." @default.
• W4311448089 created "2022-12-26" @default.
• W4311448089 creator A5002506582 @default.
• W4311448089 creator A5011295978 @default.
• W4311448089 creator A5026373941 @default.
• W4311448089 creator A5035437938 @default.
• W4311448089 creator A5039451111 @default.
• W4311448089 creator A5069278963 @default.
• W4311448089 creator A5071423421 @default.
• W4311448089 creator A5074614022 @default.
• W4311448089 creator A5081911878 @default.
• W4311448089 creator A5083130727 @default.
• W4311448089 creator A5090057576 @default.
• W4311448089 creator A5090120525 @default.
• W4311448089 date "2022-12-14" @default.
• W4311448089 modified "2023-10-01" @default.
• W4311448089 title "The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules" @default.
• W4311448089 cites W1508167890 @default.
• W4311448089 cites W2008525757 @default.
• W4311448089 cites W2027474840 @default.
• W4311448089 cites W2030057907 @default.
• W4311448089 cites W2051351397 @default.
• W4311448089 cites W2062458432 @default.
• W4311448089 cites W2086286404 @default.
• W4311448089 cites W2091884933 @default.
• W4311448089 cites W2092456976 @default.
• W4311448089 cites W2113364934 @default.
• W4311448089 cites W2162228329 @default.
• W4311448089 cites W2230508107 @default.
• W4311448089 cites W2328034403 @default.
• W4311448089 cites W2468193431 @default.
• W4311448089 cites W2472352469 @default.
• W4311448089 cites W2592067246 @default.
• W4311448089 cites W2773242491 @default.
• W4311448089 cites W2775249104 @default.
• W4311448089 cites W2776156094 @default.
• W4311448089 cites W2801628465 @default.
• W4311448089 cites W2889729436 @default.
• W4311448089 cites W2913590893 @default.
• W4311448089 cites W2937295472 @default.
• W4311448089 cites W2985585109 @default.
• W4311448089 cites W3010473282 @default.
• W4311448089 cites W3017113448 @default.
• W4311448089 cites W4213047757 @default.
• W4311448089 cites W4296984371 @default.
• W4311448089 cites W4308558942 @default.
• W4311448089 cites W69881358 @default.
• W4311448089 doi "https://doi.org/10.1021/acs.jmedchem.2c01693" @default.
• W4311448089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36516442" @default.
• W4311448089 hasPublicationYear "2022" @default.
• W4311448089 type Work @default.
• W4311448089 citedByCount "5" @default.
• W4311448089 countsByYear W43114480892023 @default.
• W4311448089 crossrefType "journal-article" @default.
• W4311448089 hasAuthorship W4311448089A5002506582 @default.
• W4311448089 hasAuthorship W4311448089A5011295978 @default.
• W4311448089 hasAuthorship W4311448089A5026373941 @default.
• W4311448089 hasAuthorship W4311448089A5035437938 @default.
• W4311448089 hasAuthorship W4311448089A5039451111 @default.
• W4311448089 hasAuthorship W4311448089A5069278963 @default.
• W4311448089 hasAuthorship W4311448089A5071423421 @default.
• W4311448089 hasAuthorship W4311448089A5074614022 @default.
• W4311448089 hasAuthorship W4311448089A5081911878 @default.
• W4311448089 hasAuthorship W4311448089A5083130727 @default.
• W4311448089 hasAuthorship W4311448089A5090057576 @default.
• W4311448089 hasAuthorship W4311448089A5090120525 @default.
• W4311448089 hasBestOaLocation W43114480891 @default.
• W4311448089 hasConcept C103697762 @default.
• W4311448089 hasConcept C104317684 @default.
• W4311448089 hasConcept C127716648 @default.
• W4311448089 hasConcept C142724271 @default.
• W4311448089 hasConcept C150903083 @default.
• W4311448089 hasConcept C161624437 @default.
• W4311448089 hasConcept C178790620 @default.
• W4311448089 hasConcept C184235292 @default.
• W4311448089 hasConcept C185592680 @default.
• W4311448089 hasConcept C202751555 @default.
• W4311448089 hasConcept C207001950 @default.
• W4311448089 hasConcept C2775905019 @default.
• W4311448089 hasConcept C2776925932 @default.
• W4311448089 hasConcept C2779134260 @default.
• W4311448089 hasConcept C2779335537 @default.
• W4311448089 hasConcept C55493867 @default.
• W4311448089 hasConcept C56173144 @default.
• W4311448089 hasConcept C6555983 @default.
• W4311448089 hasConcept C69366308 @default.
• W4311448089 hasConcept C70721500 @default.
• W4311448089 hasConcept C71924100 @default.
• W4311448089 hasConcept C74187038 @default.
• W4311448089 hasConcept C86803240 @default.
• W4311448089 hasConcept C98274493 @default.
• W4311448089 hasConceptScore W4311448089C103697762 @default.
• W4311448089 hasConceptScore W4311448089C104317684 @default.
• W4311448089 hasConceptScore W4311448089C127716648 @default.
• W4311448089 hasConceptScore W4311448089C142724271 @default.
• W4311448089 hasConceptScore W4311448089C150903083 @default.
• W4311448089 hasConceptScore W4311448089C161624437 @default.
• W4311448089 hasConceptScore W4311448089C178790620 @default.

• next