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• W4311448133 abstract "Active since the middle of the last century, the Società Italiana di Cardiologia (SIC) coagulates the interest of Italian cardiologists and includes 20 Study Groups as well as 13 Regional Sections, to which members from all over our country give their contribution. The SIC Study Groups, 20 in number, reach the heart of and act as professional networks deeply involved in basic and clinical research as well as in the continuous professional development of cardiologists. The SIC Study Groups bring together experts in all cardiovascular subspecialties to share expertise and facilitate the exchange of best scientific practices. They promote, design and coordinate research and produce studies, registers, consensus and review papers, also in collaboration with other scientific societies. The Study Groups also contribute to the organization of the SIC National Congress and promote scientific meetings, webinars and educational workshops in their specific areas of expertise. In essence, SIC Study Groups disseminate scientific knowledge, bringing the benefit of translational research to practicing physicians. They provide education and ongoing medical development, as is the case with this initiative finalized to gather in a special issue of the Journal of Cardiovascular Medicine the cultural and scientific contributions of the SIC Study Groups, which substantiate their level of competence, authoritativeness and originality. The cellular and molecular biology of the heart is a rapidly growing area of cardiovascular medicine that uses molecular biology techniques for the mechanistic investigation, diagnosis, prevention and treatment of cardiovascular disease (CVD). Assuming that lifestyle interventions can elicit beneficial effects on cardiometabolic diseases, the SIC study group on Cellular and Molecular Biology of the Heart provided an overview of the molecular mechanisms involved in the beneficial effects of exercise and dietary restriction in diabetes and obesity models. Three sections of the supplement are dedicated to the primary role of advanced instrumental diagnostics. A first review by the Echocardiography Study Group examines the growing potential of echocardiography, the first-line tool for managing patients with various CVDs. Second-level techniques, particularly Speckle Tracking Echocardiography, demonstrate their ability to characterize the severity of CVD from the earliest stages, while standard parameters are still within the normal range. This potentiality credits advanced echocardiography for a role as a clinical routine changer and therapy modifier. A second contribution by the Cardiac Magnetic Resonance (CMR) Study Group provides an overview of a particular aspect of recent advances in CMR in the clinical presentation of the ‘hot phase’ of different cardiomyopathies including dilated, hypertrophic and arrhythmogenic heart muscle disorders. The authors demonstrate that CMR is the gold standard imaging technique for detecting early signs of myocardial remodeling typical of the ‘hot phase’ of those nonischemic cardiomyopathies: myocardial edema, perfusion abnormalities and pathological mapping values. The third contribution in this area is provided by the Computed Tomography and Nuclear Medicine Study Group, which reviews the clinical applications of computed tomography and nuclear medicine in the context of dysregulated lipid and glucose metabolism in which dysfunction and inflammation of the adipose tissue accelerate disease progression and promote cardiovascular events in atherosclerotic patients. Regarding the most topical therapeutic problems, an expert opinion is expressed by the Interventional Cardiology Study Group. A high risk of developing recurrent cardiovascular events persists following percutaneous coronary intervention (PCI). Despite the possible, unfavorable outcome, the correct management of the residual risk of low-density lipoprotein cholesterol (LDL-c) remains a problem only partially addressed. The authors warn of suboptimal LDL-c control, poor adherence to statin therapy, and underutilization of high-intensity statins, ezetimibe and PCSK9 inhibitors after PCI. Particular attention is paid to setting up lipid-lowering therapy in the discharge phase. Still on the subject of drug therapy, the Heart Failure Study Group addresses the issue of acute and chronic heart failure with reduced ejection fraction (HFrEF), for which there is a continuing need for drug treatments that favorably influence the stability of the disease and the long-term prognosis. The authors illustrate and discuss, in the presence of an evolving HFrEF phenotype over time, the latest data on both recently approved drugs and on the development of novel therapeutic targets, in order to provide a critical overview for a personalized and targeted approach. SIC devotes special scientific attention to Congenital Heart Disease and Pediatric Cardiovascular Prevention in pediatric age, as well as to gender differences in CVD. The Pediatric Prevention Study Group investigates the issue of the origin of high blood pressure (BP) or hypertension (HTN) in childhood, with 5–10% of children and adolescents with increased BP. The review summarizes the state of the art on primary and secondary pediatric HTN, the BP cut-off to identify young hypertensives subjects and the target of individuals to whom medical therapy should be addressed, beyond the correction of an erroneous lifestyle. Extensive scientific evidence testifies that gender differences in biological substrates determine different clinical manifestations of diseases and their possible cardiovascular complications, with important implications for prevention, diagnosis and therapy in both sexes. The recent coronavirus disease 2019 (COVID-19) pandemic prompted the Gender CVD Study Group to review the evidence dedicated to this very topical issue by discussing the mechanisms of the vulnerability to COVID-19 attributable to sex-dependent biological factors and gender-related behavioral traits. Finally, the contribution from the Thrombosis Study Group summarizes the large body of evidence documenting how genetic and acquired characteristics of patients can influence the extent of platelet inhibition induced by aspirin and P2Y inhibitors in patients with coronary artery, peripheral or cerebrovascular atherosclerosis. The interest of this article comes from the proposal of a tailored antiplatelet therapy and from the practical indications on the clinical contexts in which it seems reasonable to implement antiplatelet therapy monitoring. The identification and prediction of platelet inhibition have already been shown to ensure an optimal balance between antithrombotic efficacy and bleeding risk. The present volume, which is witness to the vast and fervent activity of the SIC Study Groups, will be followed by a second volume with as many contributions. Acknowledgements Conflicts of interest There are no conflicts of interest." @default.
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• W4311448133 date "2022-12-15" @default.
• W4311448133 modified "2023-09-25" @default.
• W4311448133 title "The activity and the value of the Study Groups of the Italian Society of Cardiology" @default.
• W4311448133 doi "https://doi.org/10.2459/jcm.0000000000001414" @default.
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