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- W4311448369 abstract "Abstract Purpose: Acute exacerbation of interstitial lung disease is the leading cause of 30-day mortality among patients with lung cancer in Japan. We assessed the characteristics of the lung immune environment before the onset of acute exacerbation of interstitial lung disease. Methods: This retrospective matched case-control study comparing the immune phenotype of helper T cells in the lung from patients with and without acute exacerbation of interstitial lung disease after surgery was conducted in 135 patients who underwent surgical resection for lung cancer and were pathologically diagnosed with interstitial lung disease at our institute between 2009 and 2018. There were 13 cases of acute exacerbation of interstitial lung disease and 122 cases without acute exacerbation matched using propensity score analysis, and 12 cases in each group were compared. We evaluated the percentage of T helper (Th)1, Th2, Th17, regulatory T cells (Treg), and CD8 cells in CD3 + T cells and the Th1:Th2, Th17:Treg and CD8:Treg ratios in patients with acute exacerbation by immunostaining of lung tissue in the non-tumor area. Results: We found a significant difference in the lung Th17:Treg ratio between patients with and without acute exacerbation (1.47 and 0.79, respectively; p=0.041). However, we detected no significant differences in the percentages of lung Th1 (21.3% and 29.0%), Th2 (34.2% and 42.7%), Th17 (22.3% and 21.6%), Treg (19.6% and 29.1%), or CD8 + T cells (47.2% and 42.2%) of CD3 + T cells between groups. Conclusion: Th17:Treg ratios in the lung from patients with acute exacerbation were higher than in those without." @default.
- W4311448369 created "2022-12-26" @default.
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- W4311448369 date "2022-12-14" @default.
- W4311448369 modified "2023-10-16" @default.
- W4311448369 title "The balance between lung regulatory T cells and Th17 cells is a risk indicator for the acute exacerbation of interstitial lung disease after surgery" @default.
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- W4311448369 doi "https://doi.org/10.21203/rs.3.rs-2364399/v1" @default.
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