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• W4311448414 endingPage "100" @default.
• W4311448414 startingPage "83" @default.
• W4311448414 abstract "Although tuberculosis (TB) is preventable and curable, the lengthy treatment (generally 6 months), poor patient adherence, high inter-individual variability in pharmacokinetics (PK), emergence of drug resistance, presence of comorbidities, and adverse drug reactions complicate TB therapy and drive the need for new drugs and/or regimens. Hence, new compounds are being developed, available drugs are repurposed, and the dosing of existing drugs is optimized, resulting in the largest drug development portfolio in TB history. This review highlights a selection of clinically available drug candidates that could be part of future TB regimens, including bedaquiline, delamanid, pretomanid, linezolid, clofazimine, optimized (high dose) rifampicin, rifapentine, and para-aminosalicylic acid. The review covers drug development history, preclinical data, PK, and current clinical development." @default.
• W4311448414 created "2022-12-26" @default.
• W4311448414 creator A5010141975 @default.
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• W4311448414 creator A5085054904 @default.
• W4311448414 date "2022-12-14" @default.
• W4311448414 modified "2023-10-10" @default.
• W4311448414 title "New and Repurposed Drugs for the Treatment of Active Tuberculosis: An Update for Clinicians" @default.
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