Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311448450> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W4311448450 endingPage "e38" @default.
- W4311448450 startingPage "e29" @default.
- W4311448450 abstract "The management of acute stroke is challenging. The aim of this meta-analysis was to determine the efficacy and tolerability of edaravone, with or without thrombolytic therapy, in the treatment of patients with acute ischemic stroke.The PubMed, EMBASE, and Cochrane databases were searched for randomized controlled trials (RCTs) and cohort studies. Mean differences (MD), risk ratios (RR), 95% confidence interval (CI), and heterogeneity were calculated.Totals of nine RCTs and four cohort studies were included, for a total of 2102 patients. In patients with acute ischemic stroke, edaravone monotherapy was associated with significantly improved Barthel Index of functioning in activities for daily living (MD, 23.95; 95% CI, 18.48 to 29.41; P < 0.001) and neurologic deficit, (as measured using the National Institutes of Health Stroke Scale score) (MD = -3.49; 95% CI, -5.76 to 1.22; P = 0.003), on short-term follow-up. However, edaravone was not associated with an improved rate of death or disability (RR = 0.75; 95% CI, 0.45 to 1.23; P = 0.25) on long-term follow-up.When plus to thrombolytic therapy, edaravone was associated with significant improvements in recanalization rate (RR = 1.71; 95% CI, 1.05 to 2.77; P = 0.03) and neurologic deficit (MD = 3.97; 95% CI, 5.14 to 2.79; P < 0.001), without an increase in the prevalence of bleeding events (RR = 1.11; 95% CI, 0.76 to 1.62; P = 0.59). However, edaravone did not have a significant effect on death or disability (RR = 0.85; 95% CI, 0.69 to 1.04; P = 0.12).Based on the findings from the present meta-analysis, edaravone was an effective and well-tolerated neuroprotective agent in these patients with ischemic stroke. With the use of edaravone, activities of daily living and neurologic deficits, along with recanalization rates, were improved on short-term follow-up, but the long-term effects still need confirmation in larger-scale clinical trials." @default.
- W4311448450 created "2022-12-26" @default.
- W4311448450 creator A5017874284 @default.
- W4311448450 creator A5018158429 @default.
- W4311448450 creator A5021104158 @default.
- W4311448450 creator A5072397986 @default.
- W4311448450 creator A5076725781 @default.
- W4311448450 date "2022-12-01" @default.
- W4311448450 modified "2023-09-26" @default.
- W4311448450 title "Edaravone for Acute Ischemic Stroke: A Systematic Review and Meta-analysis" @default.
- W4311448450 cites W1970421321 @default.
- W4311448450 cites W1985385437 @default.
- W4311448450 cites W1989011562 @default.
- W4311448450 cites W2003263443 @default.
- W4311448450 cites W2045803099 @default.
- W4311448450 cites W2047644516 @default.
- W4311448450 cites W2051921427 @default.
- W4311448450 cites W2058628407 @default.
- W4311448450 cites W2065031308 @default.
- W4311448450 cites W2077547773 @default.
- W4311448450 cites W2082665716 @default.
- W4311448450 cites W2088495857 @default.
- W4311448450 cites W2098923148 @default.
- W4311448450 cites W2156098321 @default.
- W4311448450 cites W2171116737 @default.
- W4311448450 cites W2188308812 @default.
- W4311448450 cites W2247323096 @default.
- W4311448450 cites W2564917343 @default.
- W4311448450 cites W2581410673 @default.
- W4311448450 cites W2791059487 @default.
- W4311448450 cites W2921394742 @default.
- W4311448450 cites W2981241390 @default.
- W4311448450 cites W2991792334 @default.
- W4311448450 cites W3008827745 @default.
- W4311448450 cites W3112418394 @default.
- W4311448450 cites W3129319285 @default.
- W4311448450 cites W4211247746 @default.
- W4311448450 cites W4255683973 @default.
- W4311448450 doi "https://doi.org/10.1016/j.clinthera.2022.11.005" @default.
- W4311448450 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36473732" @default.
- W4311448450 hasPublicationYear "2022" @default.
- W4311448450 type Work @default.
- W4311448450 citedByCount "0" @default.
- W4311448450 crossrefType "journal-article" @default.
- W4311448450 hasAuthorship W4311448450A5017874284 @default.
- W4311448450 hasAuthorship W4311448450A5018158429 @default.
- W4311448450 hasAuthorship W4311448450A5021104158 @default.
- W4311448450 hasAuthorship W4311448450A5072397986 @default.
- W4311448450 hasAuthorship W4311448450A5076725781 @default.
- W4311448450 hasConcept C126322002 @default.
- W4311448450 hasConcept C127413603 @default.
- W4311448450 hasConcept C168563851 @default.
- W4311448450 hasConcept C197934379 @default.
- W4311448450 hasConcept C2778375690 @default.
- W4311448450 hasConcept C2779554857 @default.
- W4311448450 hasConcept C2780645631 @default.
- W4311448450 hasConcept C44249647 @default.
- W4311448450 hasConcept C71924100 @default.
- W4311448450 hasConcept C72563966 @default.
- W4311448450 hasConcept C78519656 @default.
- W4311448450 hasConcept C82789193 @default.
- W4311448450 hasConcept C95190672 @default.
- W4311448450 hasConceptScore W4311448450C126322002 @default.
- W4311448450 hasConceptScore W4311448450C127413603 @default.
- W4311448450 hasConceptScore W4311448450C168563851 @default.
- W4311448450 hasConceptScore W4311448450C197934379 @default.
- W4311448450 hasConceptScore W4311448450C2778375690 @default.
- W4311448450 hasConceptScore W4311448450C2779554857 @default.
- W4311448450 hasConceptScore W4311448450C2780645631 @default.
- W4311448450 hasConceptScore W4311448450C44249647 @default.
- W4311448450 hasConceptScore W4311448450C71924100 @default.
- W4311448450 hasConceptScore W4311448450C72563966 @default.
- W4311448450 hasConceptScore W4311448450C78519656 @default.
- W4311448450 hasConceptScore W4311448450C82789193 @default.
- W4311448450 hasConceptScore W4311448450C95190672 @default.
- W4311448450 hasIssue "12" @default.
- W4311448450 hasLocation W43114484501 @default.
- W4311448450 hasLocation W43114484502 @default.
- W4311448450 hasOpenAccess W4311448450 @default.
- W4311448450 hasPrimaryLocation W43114484501 @default.
- W4311448450 hasRelatedWork W1885119863 @default.
- W4311448450 hasRelatedWork W2114346778 @default.
- W4311448450 hasRelatedWork W2335438131 @default.
- W4311448450 hasRelatedWork W2531052508 @default.
- W4311448450 hasRelatedWork W2592774827 @default.
- W4311448450 hasRelatedWork W2626084264 @default.
- W4311448450 hasRelatedWork W2903890959 @default.
- W4311448450 hasRelatedWork W3149153096 @default.
- W4311448450 hasRelatedWork W4212933565 @default.
- W4311448450 hasRelatedWork W4379197432 @default.
- W4311448450 hasVolume "44" @default.
- W4311448450 isParatext "false" @default.
- W4311448450 isRetracted "false" @default.
- W4311448450 workType "article" @default.