Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311449861> ?p ?o ?g. }
- W4311449861 abstract "ABSTRACT HELLP syndrome is a life-threatening complication of pregnancy, which is often secondary to preeclampsia. To date, there is no biomarker in clinical use for the early stratification of women with preeclampsia that are under increased risk for HELLP syndrome. Herein, we show that the levels of circulating developmental endothelial locus-1 ( DEL-1), which is an extracellular immunomodulatory protein, are decreased in patients with HELLP syndrome compared to preeclampsia. DEL-1 levels are also negatively correlated with the circulating levels of kidney injury molecule-1 (KIM-1), which is a biomarker for disorders associated with kidney damage. Receiver-operating characteristic curve analysis for DEL-1 levels and the DEL-1 to KIM-1 ratio demonstrated that these values could be used as a potential biomarker that distinguishes patients with HELLP syndrome and preeclampsia. Finally, we show that placental endothelial cells are a source for DEL-1 and the expression of this protein in placenta from patients with HELLP syndrome is minimal. Taken together, this study shows that DEL-1 is downregulated in HELLP syndrome both in the circulation and at the affected placental tissue, suggesting a potential role for this protein as a biomarker, which has to be further evaluated." @default.
- W4311449861 created "2022-12-26" @default.
- W4311449861 creator A5015156714 @default.
- W4311449861 creator A5016870802 @default.
- W4311449861 creator A5018221472 @default.
- W4311449861 creator A5035050571 @default.
- W4311449861 creator A5039777905 @default.
- W4311449861 creator A5044477980 @default.
- W4311449861 creator A5056630171 @default.
- W4311449861 creator A5065637664 @default.
- W4311449861 creator A5071387705 @default.
- W4311449861 creator A5088141005 @default.
- W4311449861 creator A5089558065 @default.
- W4311449861 date "2022-12-14" @default.
- W4311449861 modified "2023-10-16" @default.
- W4311449861 title "Decreased levels of soluble Developmental endothelial locus-1 are associated with thrombotic microangiopathy in pregnancy" @default.
- W4311449861 cites W1970283968 @default.
- W4311449861 cites W1978557995 @default.
- W4311449861 cites W1984131299 @default.
- W4311449861 cites W2006522274 @default.
- W4311449861 cites W2025961381 @default.
- W4311449861 cites W2045015953 @default.
- W4311449861 cites W2045421375 @default.
- W4311449861 cites W2049983920 @default.
- W4311449861 cites W2060853935 @default.
- W4311449861 cites W2084800734 @default.
- W4311449861 cites W2108571057 @default.
- W4311449861 cites W2162306390 @default.
- W4311449861 cites W2164469730 @default.
- W4311449861 cites W2164819474 @default.
- W4311449861 cites W2607937765 @default.
- W4311449861 cites W2747776510 @default.
- W4311449861 cites W2899909210 @default.
- W4311449861 cites W2922399346 @default.
- W4311449861 cites W2969430087 @default.
- W4311449861 cites W2972400612 @default.
- W4311449861 cites W3095638212 @default.
- W4311449861 cites W3146999786 @default.
- W4311449861 cites W4210846583 @default.
- W4311449861 cites W4235538415 @default.
- W4311449861 cites W4251118184 @default.
- W4311449861 doi "https://doi.org/10.1101/2022.12.12.22283397" @default.
- W4311449861 hasPublicationYear "2022" @default.
- W4311449861 type Work @default.
- W4311449861 citedByCount "0" @default.
- W4311449861 crossrefType "posted-content" @default.
- W4311449861 hasAuthorship W4311449861A5015156714 @default.
- W4311449861 hasAuthorship W4311449861A5016870802 @default.
- W4311449861 hasAuthorship W4311449861A5018221472 @default.
- W4311449861 hasAuthorship W4311449861A5035050571 @default.
- W4311449861 hasAuthorship W4311449861A5039777905 @default.
- W4311449861 hasAuthorship W4311449861A5044477980 @default.
- W4311449861 hasAuthorship W4311449861A5056630171 @default.
- W4311449861 hasAuthorship W4311449861A5065637664 @default.
- W4311449861 hasAuthorship W4311449861A5071387705 @default.
- W4311449861 hasAuthorship W4311449861A5088141005 @default.
- W4311449861 hasAuthorship W4311449861A5089558065 @default.
- W4311449861 hasBestOaLocation W43114498611 @default.
- W4311449861 hasConcept C126322002 @default.
- W4311449861 hasConcept C134018914 @default.
- W4311449861 hasConcept C172680121 @default.
- W4311449861 hasConcept C2776953305 @default.
- W4311449861 hasConcept C2777218350 @default.
- W4311449861 hasConcept C2777878052 @default.
- W4311449861 hasConcept C2779134260 @default.
- W4311449861 hasConcept C2779234561 @default.
- W4311449861 hasConcept C2780091579 @default.
- W4311449861 hasConcept C2780537801 @default.
- W4311449861 hasConcept C2781197716 @default.
- W4311449861 hasConcept C54355233 @default.
- W4311449861 hasConcept C55493867 @default.
- W4311449861 hasConcept C71924100 @default.
- W4311449861 hasConcept C86803240 @default.
- W4311449861 hasConceptScore W4311449861C126322002 @default.
- W4311449861 hasConceptScore W4311449861C134018914 @default.
- W4311449861 hasConceptScore W4311449861C172680121 @default.
- W4311449861 hasConceptScore W4311449861C2776953305 @default.
- W4311449861 hasConceptScore W4311449861C2777218350 @default.
- W4311449861 hasConceptScore W4311449861C2777878052 @default.
- W4311449861 hasConceptScore W4311449861C2779134260 @default.
- W4311449861 hasConceptScore W4311449861C2779234561 @default.
- W4311449861 hasConceptScore W4311449861C2780091579 @default.
- W4311449861 hasConceptScore W4311449861C2780537801 @default.
- W4311449861 hasConceptScore W4311449861C2781197716 @default.
- W4311449861 hasConceptScore W4311449861C54355233 @default.
- W4311449861 hasConceptScore W4311449861C55493867 @default.
- W4311449861 hasConceptScore W4311449861C71924100 @default.
- W4311449861 hasConceptScore W4311449861C86803240 @default.
- W4311449861 hasLocation W43114498611 @default.
- W4311449861 hasOpenAccess W4311449861 @default.
- W4311449861 hasPrimaryLocation W43114498611 @default.
- W4311449861 hasRelatedWork W2049201988 @default.
- W4311449861 hasRelatedWork W2127085070 @default.
- W4311449861 hasRelatedWork W2145510864 @default.
- W4311449861 hasRelatedWork W2736972078 @default.
- W4311449861 hasRelatedWork W2792800245 @default.
- W4311449861 hasRelatedWork W3177541807 @default.
- W4311449861 hasRelatedWork W3217512817 @default.
- W4311449861 hasRelatedWork W4285220050 @default.
- W4311449861 hasRelatedWork W4311449861 @default.