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- W4311451619 startingPage "790" @default.
- W4311451619 abstract "Widespread antibiotic resistance genes (ARGs) have emerged as a focus of attention for public health. Transformation is essential for ARGs dissemination in soils and associated environments; however, the mechanisms of how soil components contribute to the transformation of ARGs remain elusive. Here we demonstrate that three representative mineral-humic acid (HA) composites exert contrasting influence on the transformation of plasmid-borne ARGs in Bacillus subtilis. Mineral surface-bound HA facilitated transformation in kaolinite and montmorillonite systems, while an inhibitory effect of HA was observed for goethite. The elevated transformation by HA-coated kaolinite was mainly attributed to the enhanced activity of competence-stimulating factor (CSF), while increased transformation by montmorillonite-HA composites was assigned to the weakened adsorption affinity of DNA and enhanced gene expression induced by flagella-driven cell motility. In goethite system, HA played an overriding role in suppressing transformation via alleviation of cell membrane damage. The results obtained offer insights into the divergent mechanisms of humic substances in modulating bacterial transformation by soil minerals. Our findings would help for a better understanding on the fate of ARGs in soil systems and provide potentials for the utilization of soil components, particularly organic matter, to mitigate the spread of ARGs in a range of settings." @default.
- W4311451619 created "2022-12-26" @default.
- W4311451619 creator A5007285789 @default.
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- W4311451619 creator A5089516992 @default.
- W4311451619 date "2022-12-14" @default.
- W4311451619 modified "2023-10-09" @default.
- W4311451619 title "Dichotomous Role of Humic Substances in Modulating Transformation of Antibiotic Resistance Genes in Mineral Systems" @default.
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- W4311451619 doi "https://doi.org/10.1021/acs.est.2c06410" @default.
- W4311451619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36516830" @default.
- W4311451619 hasPublicationYear "2022" @default.
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