Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311452584> ?p ?o ?g. }
- W4311452584 abstract "Abstract Animal pigment patterns are excellent models to elucidate mechanisms of biological organization. Although theoretical simulations, such as Turing reaction-diffusion systems, recapitulate many animal patterns, they are insufficient to account for those showing a high degree of spatial organization and reproducibility. Here, we study the coat of the African striped mouse ( Rhabdomys pumilio ) to uncover how periodic stripes form. By combining transcriptomics, mathematical modeling, and mouse transgenics, we show that Sfrp2 regulates the distribution of hair follicles and establishes an embryonic prepattern that foreshadows pigment stripes. Moreover, using in vivo gene editing, we find that Sfrp2 knockout produces changes in coat pattern. Strikingly, mutants also exhibit pigmentation differences, revealing an additional function of Sfrp2 in regulating hair color. Thus, a single factor controls coat pattern formation by acting both as an orienting signaling mechanism and a modulator of pigmentation." @default.
- W4311452584 created "2022-12-26" @default.
- W4311452584 creator A5002366704 @default.
- W4311452584 creator A5006319656 @default.
- W4311452584 creator A5019041460 @default.
- W4311452584 creator A5036105851 @default.
- W4311452584 creator A5037405025 @default.
- W4311452584 creator A5052925180 @default.
- W4311452584 creator A5055671592 @default.
- W4311452584 creator A5063809769 @default.
- W4311452584 creator A5072777060 @default.
- W4311452584 creator A5076311980 @default.
- W4311452584 creator A5083732158 @default.
- W4311452584 creator A5084589194 @default.
- W4311452584 creator A5091225024 @default.
- W4311452584 date "2022-12-14" @default.
- W4311452584 modified "2023-10-15" @default.
- W4311452584 title "<i>Sfrp2</i>is a multifunctional regulator of rodent coat patterns" @default.
- W4311452584 cites W1828641238 @default.
- W4311452584 cites W1966228269 @default.
- W4311452584 cites W1979814807 @default.
- W4311452584 cites W1985072454 @default.
- W4311452584 cites W1988564545 @default.
- W4311452584 cites W1990768206 @default.
- W4311452584 cites W1994040734 @default.
- W4311452584 cites W2002404925 @default.
- W4311452584 cites W2019477867 @default.
- W4311452584 cites W2034432190 @default.
- W4311452584 cites W2037486322 @default.
- W4311452584 cites W2045202298 @default.
- W4311452584 cites W2048252195 @default.
- W4311452584 cites W2052723831 @default.
- W4311452584 cites W2053479367 @default.
- W4311452584 cites W2062737417 @default.
- W4311452584 cites W2070942486 @default.
- W4311452584 cites W2088937096 @default.
- W4311452584 cites W2089840306 @default.
- W4311452584 cites W2091643574 @default.
- W4311452584 cites W2102512718 @default.
- W4311452584 cites W2106771547 @default.
- W4311452584 cites W2109069210 @default.
- W4311452584 cites W2129727010 @default.
- W4311452584 cites W2142872318 @default.
- W4311452584 cites W2143654566 @default.
- W4311452584 cites W2150131459 @default.
- W4311452584 cites W2175719052 @default.
- W4311452584 cites W2212799523 @default.
- W4311452584 cites W2228162895 @default.
- W4311452584 cites W2273101790 @default.
- W4311452584 cites W2510356781 @default.
- W4311452584 cites W2547794687 @default.
- W4311452584 cites W2551208493 @default.
- W4311452584 cites W2774331694 @default.
- W4311452584 cites W2788593837 @default.
- W4311452584 cites W2796408522 @default.
- W4311452584 cites W2803479625 @default.
- W4311452584 cites W2817838603 @default.
- W4311452584 cites W2906461396 @default.
- W4311452584 cites W2908317534 @default.
- W4311452584 cites W2920311797 @default.
- W4311452584 cites W2949177718 @default.
- W4311452584 cites W2952615074 @default.
- W4311452584 cites W2966301418 @default.
- W4311452584 cites W2969599897 @default.
- W4311452584 cites W2973095164 @default.
- W4311452584 cites W3002950822 @default.
- W4311452584 cites W3035054816 @default.
- W4311452584 cites W3096377085 @default.
- W4311452584 cites W3101826276 @default.
- W4311452584 cites W3197803722 @default.
- W4311452584 cites W3214389602 @default.
- W4311452584 cites W4205496949 @default.
- W4311452584 doi "https://doi.org/10.1101/2022.12.12.520043" @default.
- W4311452584 hasPublicationYear "2022" @default.
- W4311452584 type Work @default.
- W4311452584 citedByCount "0" @default.
- W4311452584 crossrefType "posted-content" @default.
- W4311452584 hasAuthorship W4311452584A5002366704 @default.
- W4311452584 hasAuthorship W4311452584A5006319656 @default.
- W4311452584 hasAuthorship W4311452584A5019041460 @default.
- W4311452584 hasAuthorship W4311452584A5036105851 @default.
- W4311452584 hasAuthorship W4311452584A5037405025 @default.
- W4311452584 hasAuthorship W4311452584A5052925180 @default.
- W4311452584 hasAuthorship W4311452584A5055671592 @default.
- W4311452584 hasAuthorship W4311452584A5063809769 @default.
- W4311452584 hasAuthorship W4311452584A5072777060 @default.
- W4311452584 hasAuthorship W4311452584A5076311980 @default.
- W4311452584 hasAuthorship W4311452584A5083732158 @default.
- W4311452584 hasAuthorship W4311452584A5084589194 @default.
- W4311452584 hasAuthorship W4311452584A5091225024 @default.
- W4311452584 hasBestOaLocation W43114525841 @default.
- W4311452584 hasConcept C104317684 @default.
- W4311452584 hasConcept C127716648 @default.
- W4311452584 hasConcept C137620995 @default.
- W4311452584 hasConcept C138885662 @default.
- W4311452584 hasConcept C145103041 @default.
- W4311452584 hasConcept C150194340 @default.
- W4311452584 hasConcept C162317418 @default.
- W4311452584 hasConcept C18903297 @default.
- W4311452584 hasConcept C196843134 @default.