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- W4311453062 abstract "<h2>Abstract</h2> Biliary atresia (BA) is an idiopathic, progressive, fibroinflammatory, and obliterative disease of the biliary tract that manifests in the neonatal period with scleral icterus, acholic stools, conjugated hyperbilirubinemia, and elevated serum-gamma glutamyl transferase. Definitive diagnosis is established by a multi-disciplinary team comprising of pediatricians, hepatologists, radiologists, surgeons, and pathologists. It is currently the most common cause of pediatric liver transplantation in the USA and worldwide. More than 100 diseases can present with neonatal cholestasis mimicking BA. Early diagnosis (<60 days of age) with a timely Kasai portoenterostomy (KP) is crucial to relieve biliary obstruction and achieve longer native liver survival. Histopathologic features of BA can differ based on age and specific surgical interventions. This review describes histopathologic features of BA at various stages and focuses on a variety of common and uncommon diseases mimicking BA. With the increasing use of molecular testing and comprehensive genetic cholestasis panels, several patients who would have otherwise been diagnosed as BA, are now classified with specific genetic conditions leading to cholestasis." @default.
- W4311453062 created "2022-12-26" @default.
- W4311453062 creator A5027564399 @default.
- W4311453062 date "2023-01-01" @default.
- W4311453062 modified "2023-09-30" @default.
- W4311453062 title "Biliary atresia and its mimics" @default.
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- W4311453062 doi "https://doi.org/10.1016/j.mpdhp.2022.11.001" @default.
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