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• W4311456713 abstract "Understanding the mechanisms by which populations of bacteria resist antibiotics has implications in evolution, microbial ecology, and public health. The inoculum effect (IE), where antibiotic efficacy declines as the density of a bacterial population increases, has been observed for multiple bacterial species and antibiotics. Several mechanisms to account for IE have been proposed, but most lack experimental evidence or cannot explain IE for multiple antibiotics. We show that growth productivity, the combined effect of growth and metabolism, can account for IE for multiple bactericidal antibiotics and bacterial species. Guided by flux balance analysis and whole-genome modeling, we show that the carbon source supplied in the growth medium determines growth productivity. If growth productivity is sufficiently high, IE is eliminated. Our results may lead to approaches to reduce IE in the clinic, help standardize the analysis of antibiotics, and further our understanding of how bacteria evolve resistance." @default.
• W4311456713 created "2022-12-26" @default.
• W4311456713 creator A5003571578 @default.
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• W4311456713 creator A5061209787 @default.
• W4311456713 creator A5061221967 @default.
• W4311456713 creator A5062621279 @default.
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• W4311456713 creator A5080009166 @default.
• W4311456713 creator A5081221671 @default.
• W4311456713 creator A5084131609 @default.
• W4311456713 date "2022-12-14" @default.
• W4311456713 modified "2023-09-23" @default.
• W4311456713 title "Growth productivity as a determinant of the inoculum effect for bactericidal antibiotics" @default.
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