Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311456741> ?p ?o ?g. }
- W4311456741 abstract "Despite the success of cancer immunotherapies such as programmed cell death-1 (PD-1) and PD-1 ligand 1 (PD-L1) inhibitors, patients often develop resistance. New combination therapies with PD-1/PD-L1 inhibitors are needed to overcome this issue. Bezafibrate, a ligand of peroxisome proliferator-activated receptor-γ coactivator 1α/peroxisome proliferator-activated receptor complexes, has shown a synergistic antitumor effect with PD-1 blockade in mice that is mediated by activation of mitochondria in T cells. We have therefore now performed a phase 1 trial (UMIN000017854) of bezafibrate with nivolumab in previously treated patients with advanced non-small cell lung cancer. The primary end point was the percentage of patients who experience dose-limiting toxicity, and this combination regimen was found to be well tolerated. Preplanned comprehensive analysis of plasma metabolites and gene expression in peripheral cytotoxic T cells indicated that bezafibrate promoted T cell function through up-regulation of mitochondrial metabolism including fatty acid oxidation and may thereby have prolonged the duration of response. This combination strategy targeting T cell metabolism thus has the potential to maintain antitumor activity of immune checkpoint inhibitors and warrants further validation." @default.
- W4311456741 created "2022-12-26" @default.
- W4311456741 creator A5000091112 @default.
- W4311456741 creator A5001014240 @default.
- W4311456741 creator A5003016795 @default.
- W4311456741 creator A5004282323 @default.
- W4311456741 creator A5015524135 @default.
- W4311456741 creator A5019039647 @default.
- W4311456741 creator A5031416058 @default.
- W4311456741 creator A5033969315 @default.
- W4311456741 creator A5041681167 @default.
- W4311456741 creator A5041785331 @default.
- W4311456741 creator A5042371436 @default.
- W4311456741 creator A5044882193 @default.
- W4311456741 creator A5045527646 @default.
- W4311456741 creator A5048430186 @default.
- W4311456741 creator A5048538074 @default.
- W4311456741 creator A5050281248 @default.
- W4311456741 creator A5065027118 @default.
- W4311456741 creator A5066482394 @default.
- W4311456741 creator A5072724155 @default.
- W4311456741 creator A5075087521 @default.
- W4311456741 creator A5089237578 @default.
- W4311456741 creator A5090487149 @default.
- W4311456741 creator A5091620215 @default.
- W4311456741 date "2022-12-14" @default.
- W4311456741 modified "2023-10-14" @default.
- W4311456741 title "Combination bezafibrate and nivolumab treatment of patients with advanced non–small cell lung cancer" @default.
- W4311456741 cites W1963449298 @default.
- W4311456741 cites W1976714959 @default.
- W4311456741 cites W1983466841 @default.
- W4311456741 cites W1999324987 @default.
- W4311456741 cites W2023535481 @default.
- W4311456741 cites W2049553585 @default.
- W4311456741 cites W2060494021 @default.
- W4311456741 cites W2080634512 @default.
- W4311456741 cites W2093854853 @default.
- W4311456741 cites W2100039832 @default.
- W4311456741 cites W2116676186 @default.
- W4311456741 cites W2122261315 @default.
- W4311456741 cites W2126337135 @default.
- W4311456741 cites W2132656152 @default.
- W4311456741 cites W2144353489 @default.
- W4311456741 cites W2158217645 @default.
- W4311456741 cites W2160697532 @default.
- W4311456741 cites W2209812019 @default.
- W4311456741 cites W2286888244 @default.
- W4311456741 cites W2329906190 @default.
- W4311456741 cites W2527905628 @default.
- W4311456741 cites W2573158190 @default.
- W4311456741 cites W2755181857 @default.
- W4311456741 cites W2765474597 @default.
- W4311456741 cites W2765943070 @default.
- W4311456741 cites W2766674449 @default.
- W4311456741 cites W2791043965 @default.
- W4311456741 cites W2796582438 @default.
- W4311456741 cites W2883256340 @default.
- W4311456741 cites W2888346100 @default.
- W4311456741 cites W2892640821 @default.
- W4311456741 cites W2907549567 @default.
- W4311456741 cites W2944860885 @default.
- W4311456741 cites W2970081136 @default.
- W4311456741 cites W2991483702 @default.
- W4311456741 cites W2995697375 @default.
- W4311456741 cites W2996923341 @default.
- W4311456741 cites W3011706914 @default.
- W4311456741 cites W3015860015 @default.
- W4311456741 cites W3034810867 @default.
- W4311456741 cites W3039388108 @default.
- W4311456741 cites W3041721952 @default.
- W4311456741 cites W3071840836 @default.
- W4311456741 cites W3091399767 @default.
- W4311456741 cites W3121907365 @default.
- W4311456741 cites W3134659811 @default.
- W4311456741 cites W3152878368 @default.
- W4311456741 cites W3196898938 @default.
- W4311456741 cites W4210394199 @default.
- W4311456741 cites W4211001418 @default.
- W4311456741 cites W4294138012 @default.
- W4311456741 cites W783132086 @default.
- W4311456741 doi "https://doi.org/10.1126/scitranslmed.abq0021" @default.
- W4311456741 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36516270" @default.
- W4311456741 hasPublicationYear "2022" @default.
- W4311456741 type Work @default.
- W4311456741 citedByCount "5" @default.
- W4311456741 countsByYear W43114567412023 @default.
- W4311456741 crossrefType "journal-article" @default.
- W4311456741 hasAuthorship W4311456741A5000091112 @default.
- W4311456741 hasAuthorship W4311456741A5001014240 @default.
- W4311456741 hasAuthorship W4311456741A5003016795 @default.
- W4311456741 hasAuthorship W4311456741A5004282323 @default.
- W4311456741 hasAuthorship W4311456741A5015524135 @default.
- W4311456741 hasAuthorship W4311456741A5019039647 @default.
- W4311456741 hasAuthorship W4311456741A5031416058 @default.
- W4311456741 hasAuthorship W4311456741A5033969315 @default.
- W4311456741 hasAuthorship W4311456741A5041681167 @default.
- W4311456741 hasAuthorship W4311456741A5041785331 @default.
- W4311456741 hasAuthorship W4311456741A5042371436 @default.
- W4311456741 hasAuthorship W4311456741A5044882193 @default.
- W4311456741 hasAuthorship W4311456741A5045527646 @default.