FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311457514> ?p ?o ?g. }

• W4311457514 endingPage "100319" @default.
• W4311457514 startingPage "100319" @default.
• W4311457514 abstract "Population studies have found that a natural human apoA-I variant, apoA-I[K107del], is strongly associated with low HDL-C but normal plasma apoA-I levels. We aimed to reveal properties of this variant that contribute to its unusual phenotype associated with atherosclerosis. Our oil-drop tensiometry studies revealed that compared to WT, recombinant apoA-I[K107del] adsorbed to surfaces of POPC-coated triolein drops at faster rates, remodeled the surfaces to a greater extent, and was ejected from the surfaces at higher surface pressures on compression of the lipid drops. These properties may drive increased binding of apoA-I[K107del] to and its better retention on large triglyceride-rich lipoproteins, thereby increasing the variant's content on these lipoproteins. While K107del did not affect apoA-I capacity to promote ABCA1-mediated cholesterol efflux from J774 cells, it impaired the biogenesis of large nascent HDL particles resulting in the formation of predominantly smaller nascent HDL. Size-exclusion chromatography of spontaneously reconstituted 1,2-dimyristoylphosphatidylcholine-apoA-I complexes showed that apoA-I[K107del] had a hampered ability to form larger complexes but formed efficiently smaller-sized complexes. CD analysis revealed a reduced ability of apoA-I[K107del] to increase α-helical structure on binding to 1,2-dimyristoylphosphatidylcholine or in the presence of trifluoroethanol. This property may hinder the formation of large apoA-I[K107del]-containing discoidal and spherical HDL but not smaller HDL. Both factors, the increased content of apoA-I[K107del] on triglyceride-rich lipoproteins and the impaired ability of the variant to stabilize large HDL particles resulting in reduced lipid:protein ratios in HDL, may contribute to normal plasma apoA-I levels along with low HDL-C and increased risk for CVD." @default.
• W4311457514 created "2022-12-26" @default.
• W4311457514 creator A5013444389 @default.
• W4311457514 creator A5024374500 @default.
• W4311457514 creator A5034695786 @default.
• W4311457514 creator A5042465286 @default.
• W4311457514 creator A5085977786 @default.
• W4311457514 date "2023-02-01" @default.
• W4311457514 modified "2023-10-14" @default.
• W4311457514 title "Human apoA-I[Lys107del] mutation affects lipid surface behavior of apoA-I and its ability to form large nascent HDL" @default.
• W4311457514 cites W1489280123 @default.
• W4311457514 cites W1580211147 @default.
• W4311457514 cites W1585878980 @default.
• W4311457514 cites W1719108898 @default.
• W4311457514 cites W1964556269 @default.
• W4311457514 cites W1966833519 @default.
• W4311457514 cites W1972479546 @default.
• W4311457514 cites W1973646070 @default.
• W4311457514 cites W1977597405 @default.
• W4311457514 cites W1978921170 @default.
• W4311457514 cites W1985480771 @default.
• W4311457514 cites W1989242866 @default.
• W4311457514 cites W1993718080 @default.
• W4311457514 cites W1994483831 @default.
• W4311457514 cites W2004344386 @default.
• W4311457514 cites W2011018602 @default.
• W4311457514 cites W2012650964 @default.
• W4311457514 cites W2015544793 @default.
• W4311457514 cites W2016908255 @default.
• W4311457514 cites W2016918979 @default.
• W4311457514 cites W2021267305 @default.
• W4311457514 cites W2024271923 @default.
• W4311457514 cites W2024616958 @default.
• W4311457514 cites W2031661692 @default.
• W4311457514 cites W2033019705 @default.
• W4311457514 cites W2037303704 @default.
• W4311457514 cites W2041759991 @default.
• W4311457514 cites W2048387303 @default.
• W4311457514 cites W2051560414 @default.
• W4311457514 cites W2055194273 @default.
• W4311457514 cites W2060956030 @default.
• W4311457514 cites W2061255861 @default.
• W4311457514 cites W2063174765 @default.
• W4311457514 cites W2070162893 @default.
• W4311457514 cites W2074535217 @default.
• W4311457514 cites W2077406753 @default.
• W4311457514 cites W2077919198 @default.
• W4311457514 cites W2083980074 @default.
• W4311457514 cites W2121076428 @default.
• W4311457514 cites W2129341775 @default.
• W4311457514 cites W2130959507 @default.
• W4311457514 cites W2135806933 @default.
• W4311457514 cites W2151736987 @default.
• W4311457514 cites W2157644622 @default.
• W4311457514 cites W2163655701 @default.
• W4311457514 cites W2165906160 @default.
• W4311457514 cites W2165958172 @default.
• W4311457514 cites W2166950287 @default.
• W4311457514 cites W2177021195 @default.
• W4311457514 cites W2334667221 @default.
• W4311457514 cites W2423399237 @default.
• W4311457514 cites W2770241117 @default.
• W4311457514 cites W2893585798 @default.
• W4311457514 cites W3087556812 @default.
• W4311457514 cites W3103153839 @default.
• W4311457514 cites W3144050890 @default.
• W4311457514 cites W4207058764 @default.
• W4311457514 cites W4255328394 @default.
• W4311457514 doi "https://doi.org/10.1016/j.jlr.2022.100319" @default.
• W4311457514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36525992" @default.
• W4311457514 hasPublicationYear "2023" @default.
• W4311457514 type Work @default.
• W4311457514 citedByCount "0" @default.
• W4311457514 crossrefType "journal-article" @default.
• W4311457514 hasAuthorship W4311457514A5013444389 @default.
• W4311457514 hasAuthorship W4311457514A5024374500 @default.
• W4311457514 hasAuthorship W4311457514A5034695786 @default.
• W4311457514 hasAuthorship W4311457514A5042465286 @default.
• W4311457514 hasAuthorship W4311457514A5085977786 @default.
• W4311457514 hasBestOaLocation W43114575141 @default.
• W4311457514 hasConcept C104317684 @default.
• W4311457514 hasConcept C12554922 @default.
• W4311457514 hasConcept C131934819 @default.
• W4311457514 hasConcept C144024400 @default.
• W4311457514 hasConcept C149011108 @default.
• W4311457514 hasConcept C149923435 @default.
• W4311457514 hasConcept C181199279 @default.
• W4311457514 hasConcept C185592680 @default.
• W4311457514 hasConcept C192157962 @default.
• W4311457514 hasConcept C2777704780 @default.
• W4311457514 hasConcept C2778163477 @default.
• W4311457514 hasConcept C2778913445 @default.
• W4311457514 hasConcept C2779564620 @default.
• W4311457514 hasConcept C2779697368 @default.
• W4311457514 hasConcept C2780072125 @default.
• W4311457514 hasConcept C2780943371 @default.
• W4311457514 hasConcept C2781157690 @default.
• W4311457514 hasConcept C2908647359 @default.

• next