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• W4311458778 abstract "Objectives. To evaluate the efficacy and safety of transarterial chemoembolization (TACE) with drug-eluting beads (DEB-TACE) and lipiodol (DEB-Lipiodol TACE) in the treatment of unresectable hepatocellular carcinoma (HCC) patients. Materials and Methods. The medical records of consecutive unresectable HCC patients who underwent DEB-TACE or DEB-Lipiodol TACE from June 2016 to July 2021 were retrospectively evaluated. Therapeutic response, overall survival (OS), progression-free survival (PFS), and adverse events (AEs) were compared among the groups. Results. Three hundred and twenty-seven patients were enrolled in the study, including 293 patients in the DEB-TACE group and 34 patients in the DEB-Lipiodol TACE group. The objective response rate in the DEB-Lipiodol TACE group was 17.6%, significantly higher than that in the DEB-TACE group (5.8%, <math xmlns=http://www.w3.org/1998/Math/MathML id=M1> <mi>P</mi> <mo>=</mo> <mn>0.011</mn> </math> ). Similarly, DEB-Lipiodol TACE group also had a higher disease control rate (91.2% vs 68.6%, <math xmlns=http://www.w3.org/1998/Math/MathML id=M2> <mi>P</mi> <mo>=</mo> <mn>0.006</mn> </math> ). Median OS was 13 months (95% CI: 11.0 months and 15.0 months) and 22 months (95% CI: 17.3 months and 26.7 months) in the DEB-TACE group and DEB-Lipiodol TACE group, respectively ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M3> <mi>P</mi> <mo>=</mo> <mn>0.041</mn> </math> ). Meanwhile, median PFS was 7 months (95% CI: 5.2 months and 8.8 months) in the DEB-TACE group and 12 months (95% CI: 7.9 months and 16.1 months) in the DEB-Lipiodol TACE group ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M4> <mi>P</mi> <mo>=</mo> <mn>0.174</mn> </math> ). There was no statistically significant difference in AEs incidence among the two groups ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M5> <mi>P</mi> <mo>></mo> <mn>0.05</mn> </math> ). Conclusions. DEB-Lipiodol TACE was safe, well tolerated, and had a better efficacy compared with DEB-TACE in unresectable HCC patients." @default.
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• W4311458778 date "2022-12-14" @default.
• W4311458778 modified "2023-10-16" @default.
• W4311458778 title "Evaluation of Transarterial Chemoembolization Protocol with Drug-Eluting Beads in Combination with Lipiodol for Hepatocellular Carcinoma: A Single-Center Controlled Study" @default.
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• W4311458778 doi "https://doi.org/10.1155/2022/1090313" @default.
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