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- W4311459583 endingPage "121283" @default.
- W4311459583 startingPage "121283" @default.
- W4311459583 abstract "This study aimed to investigate the protective effects of moxibustion on ovarian dysfunction in rats with cyclophosphamide (Cy)-induced premature ovarian insufficiency (POI). It also aimed at revealing its potential mechanisms and emphasizing its role in mitigating the mitochondrial dysfunction and NLRP3 inflammatory activation. POI models were established by the intraperitoneal administration of Cy using female Sprague–Dawley rats. Moxibustion (BL23 or CV4, CV8) was used to treat POI models for fifteen days. Vaginal smears, enzyme-linked immunosorbent assay, hematoxylin-eosin, tunnel staining, flow cytometry analysis, immunohistochemistry staining, qRT-PCR, and western blotting were conducted to evaluate the ovarian function, mitochondrial dysfunction, and NLRP3 inflammatory activation in this study. Moxibustion could improve the disorder of the estrous cycles and reproductive hormone levels, promote follicular growth, reduce the number of atresia follicles, and alleviate the apoptosis of ovarian granulosa cells (GCs) in rats with POI. Furthermore, moxibustion mitigated the mitochondrial damage, reversed the elevated serum levels of IL-18 and IL-1β, and decreased their protein expression in the ovaries of rats with POI. Moxibustion significantly inhibited the expression of the mRNAs and proteins of NOD-like receptor thermal protein domain-associated protein 3 (NLRP3), apoptosis-associated speck-like protein containing a CARD (ASC), caspase 1, and gasdermin D (GSDMD) in the ovaries of rats with POI. These results supported that moxibustion may ameliorate Cy-induced POI by mitigating the mitochondrial dysfunction and NLRP3 inflammatory activation. Targeted treatment of mitochondrial damage and NLRP3 inflammatory activation may be a novel therapeutic strategy for POI." @default.
- W4311459583 created "2022-12-26" @default.
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- W4311459583 date "2023-02-01" @default.
- W4311459583 modified "2023-10-17" @default.
- W4311459583 title "Moxibustion mitigates mitochondrial dysfunction and NLRP3 inflammatory activation in cyclophosphamide-induced premature ovarian insufficiency rats" @default.
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- W4311459583 cites W1985661983 @default.
- W4311459583 cites W1986369093 @default.
- W4311459583 cites W2020091796 @default.
- W4311459583 cites W2068633454 @default.
- W4311459583 cites W2069191696 @default.
- W4311459583 cites W2101109257 @default.
- W4311459583 cites W2125483807 @default.
- W4311459583 cites W2266463006 @default.
- W4311459583 cites W2275962221 @default.
- W4311459583 cites W2289992924 @default.
- W4311459583 cites W2309700868 @default.
- W4311459583 cites W2317629072 @default.
- W4311459583 cites W2431987552 @default.
- W4311459583 cites W2515036978 @default.
- W4311459583 cites W2606232917 @default.
- W4311459583 cites W2706160875 @default.
- W4311459583 cites W2761464752 @default.
- W4311459583 cites W2779317704 @default.
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- W4311459583 cites W2884445384 @default.
- W4311459583 cites W2901583751 @default.
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- W4311459583 cites W3091806384 @default.
- W4311459583 cites W3109521801 @default.
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- W4311459583 cites W3120229241 @default.
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- W4311459583 cites W3138176531 @default.
- W4311459583 cites W3159373961 @default.
- W4311459583 cites W3164876044 @default.
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- W4311459583 cites W3172032632 @default.
- W4311459583 cites W3177319807 @default.
- W4311459583 cites W3183177995 @default.
- W4311459583 cites W3216752137 @default.
- W4311459583 cites W4210735062 @default.
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- W4311459583 cites W4213324468 @default.
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- W4311459583 doi "https://doi.org/10.1016/j.lfs.2022.121283" @default.
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- W4311459583 hasPublicationYear "2023" @default.
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