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• W4311459945 endingPage "100150" @default.
• W4311459945 startingPage "100150" @default.
• W4311459945 abstract "Significant progress in understanding cancer pathogenesis, it remains one of the leading causes of death after cardiovascular diseases. Similarly viral infections have emerged from wildlife or re-emerged, generating serious threats to the global health. As a result, there is an urgent need for the development of novel, more effective anticancer and antiviral therapeutics. Scientists, medicinal chemists and researchers are continuously finding novel targets, mechanisms and molecules against theses severe and dangerous infections. Therefore, ongoing extensively study and research emphasizes 1,3,4 thiadiazole pharmacophore have versatile pharmacological actions. Due to mesoionic behaviour of 1,3,4 thiadiazole pharmacophore allows to enter and easily cross biological membrane which allow to interact various biological proteins. In this review study an attempt has been made of various mechanisms involved in cancer and viral prevalence with updated studies done so far. This review study also findings the role of 1,3,4 thiadiazole motif in the management of various cancers and viral infection. This study also highlighting research statics on clinical trials and various patents containing 1,3,4 thiadiazole derivatives." @default.
• W4311459945 created "2022-12-26" @default.
• W4311459945 creator A5006929706 @default.
• W4311459945 creator A5019098531 @default.
• W4311459945 creator A5032013914 @default.
• W4311459945 creator A5044296448 @default.
• W4311459945 creator A5053032459 @default.
• W4311459945 creator A5055240254 @default.
• W4311459945 creator A5070125354 @default.
• W4311459945 date "2023-02-01" @default.
• W4311459945 modified "2023-10-01" @default.
• W4311459945 title "Mechanism-based approaches of 1,3,4 thiadiazole scaffolds as potent enzyme inhibitors for cytotoxicity and antiviral activity" @default.
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