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- W4311463350 abstract "This work presents a label-free optical biosensing platform by integrating the localized surface plasmon resonance (LSPR) and in-situ ellipsometry technique. A sensor chip composed of partially embedded Au-Ag alloy nanoparticles was fabricated on a glass substrate by the thermal dewetting method. The sensor chip was characterized using spectroscopic ellipsometry to determine the optical constant. The bulk RI resolution estimated from the ellipsometry phase (∆) signal was found to be 4.62 × 10−7 RIU for the bare sensor chip. Also, the biosensing experiment toward protein detection gives a detection limit of 23 pM. Further, hexagonal-boron nitride nanosheets (h-BNNS) modified sensor chip shows enhanced sensitivity with the detection limit down to 4.2 pM. The protein adsorption coefficients obtained from the fitting of kinetics data give values of 4.6 × 104 mol−1s−1 and 2.65 × 105 mol−1 s−1 for bare, and h-BNNS modified sensor chips, respectively. A theoretical simulation performed with COMSOL shows good agreement with our experimental outcomes. We believe that our proposed sensor chip enables the features of high stability, surface-sensitive, non-destructive, label-free, easy to fabricate, and cost-effectiveness, which make it feasible for large-scale production and commercialization in biomedical applications." @default.
- W4311463350 created "2022-12-26" @default.
- W4311463350 creator A5000992881 @default.
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- W4311463350 date "2023-03-01" @default.
- W4311463350 modified "2023-10-02" @default.
- W4311463350 title "In-situ label-free optical biosensing with plasmonic enhanced ellipsometry using partially-embedded bimetallic Ag-Au alloy nanoparticles" @default.
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- W4311463350 doi "https://doi.org/10.1016/j.snb.2022.133164" @default.
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