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- W4311463363 endingPage "103058" @default.
- W4311463363 startingPage "103058" @default.
- W4311463363 abstract "Brown adipose tissue (BAT) contributes to energy homeostasis via nonshivering thermogenesis. The BAT is densely innervated by the sympathetic nervous system (SNS) and activity of pre-autonomic neurons modulates the sympathetic outflow. Leptin, an adipocyte hormone, alters energy homeostasis and thermogenesis of BAT via several neuronal circuits; however, the cellular effects of leptin on interscapular BAT (iBAT)-related neurons in the hypothalamus remain to be determined. In this study, we used pseudorabies virus (PRV) to identify iBAT-related neurons in the paraventricular nucleus (PVN) of the hypothalamus and test the hypothesis that iBAT-related PVN neurons are modulated by leptin. Inoculation of iBAT with PRV in leptin receptor reporter mice (Lepr:EGFP) demonstrated that a population of iBAT-related PVN neurons expresses Lepr receptors. Our electrophysiological findings revealed that leptin application caused hyperpolarization in some of iBAT-related PVN neurons. Bath application of leptin also modulated excitatory and inhibitory neurotransmission to most of iBAT-related PVN neurons. Using channel rhodopsin assisted circuit mapping we found that GABAergic and glutamatergic Lepr-expressing neurons in the dorsomedial hypothalamus/dorsal hypothalamic area (dDMH/DHA) project to PVN neurons; however, connected iBAT-related PVN neurons receive exclusively inhibitory signals from Lepr-expressing dDMH/DHA neurons." @default.
- W4311463363 created "2022-12-26" @default.
- W4311463363 creator A5006066692 @default.
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- W4311463363 creator A5048023637 @default.
- W4311463363 creator A5054797910 @default.
- W4311463363 date "2023-03-01" @default.
- W4311463363 modified "2023-10-17" @default.
- W4311463363 title "GABAergic leptin receptor-expressing neurons in the dorsomedial hypothalamus project to brown adipose tissue-related neurons in the paraventricular nucleus of mice" @default.
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- W4311463363 doi "https://doi.org/10.1016/j.autneu.2022.103058" @default.
- W4311463363 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36538864" @default.
- W4311463363 hasPublicationYear "2023" @default.
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