FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311472421> ?p ?o ?g. }

• W4311472421 endingPage "6398" @default.
• W4311472421 startingPage "6377" @default.
• W4311472421 abstract "The blood-brain barrier (BBB) is a key obstacle to the delivery of drugs into the brain. Therefore, it is essential to develop an advanced drug delivery nanoplatform to solve this problem. We previously screened a small rabies virus glycoprotein 15 (RVG15) peptide with 15 amino acids and observed that most of the RVG15-modified nanoparticles entered the brain within 1 h of administration. The high BBB penetrability gives RVG15 great potential for brain-targeted drug delivery systems. Moreover, a multifunctional integrated nanoplatform with a high drug-loading capacity, tunable functionality, and controlled drug release is crucial for tumor treatment. Zeolitic imidazolate framework (ZIF-8) is a promising nanodrug delivery system.Inspired by the biomimetic concept, we designed RVG15-coated biomimetic ZIF-8 nanoparticles (RVG15-PEG@DTX@ZIF-8) for docetaxel (DTX) delivery to achieve efficient glioblastoma elimination in mice. This bionic nanotherapeutic system was prepared by one-pot encapsulation, followed by coating with RVG15-PEG conjugates. The size, morphology, stability, drug-loading capacity, and release of RVG15-PEG@DTX@ZIF-8 were thoroughly investigated. Additionally, we performed in vitro evaluation, cell uptake capacity, BBB penetration, and anti-migratory ability. We also conducted an in vivo evaluation of the biodistribution and anti-glioma efficacy of this bionic nanotherapeutic system in a mouse mode.In vitro studies showed that, this bionic nanotherapeutic system exhibited excellent targeting efficiency and safety in HBMECs and C6 cells and high efficiency in crossing the BBB. Furthermore, the nanoparticles cause rapid DTX accumulation in the brain, allowing deeper penetration into glioma tumors. In vivo antitumor assay results indicated that RVG15-PEG@DTX@ZIF-8 significantly inhibited glioma growth and metastasis, thereby improving the survival of tumor-bearing mice.Our study demonstrates that our bionic nanotherapeutic system using RVG15 peptides is a promising and powerful tool for crossing the BBB and treating glioblastoma." @default.
• W4311472421 created "2022-12-26" @default.
• W4311472421 creator A5004559394 @default.
• W4311472421 creator A5010892248 @default.
• W4311472421 creator A5018574064 @default.
• W4311472421 creator A5028296024 @default.
• W4311472421 creator A5030776673 @default.
• W4311472421 creator A5038635529 @default.
• W4311472421 creator A5040295342 @default.
• W4311472421 creator A5044525929 @default.
• W4311472421 creator A5050094963 @default.
• W4311472421 creator A5052776208 @default.
• W4311472421 creator A5056982346 @default.
• W4311472421 creator A5057729209 @default.
• W4311472421 creator A5066174435 @default.
• W4311472421 date "2022-12-01" @default.
• W4311472421 modified "2023-10-01" @default.
• W4311472421 title "Combined Biomimetic MOF-RVG15 Nanoformulation Efficient Over BBB for Effective Anti-Glioblastoma in Mice Model" @default.
• W4311472421 cites W1977460228 @default.
• W4311472421 cites W1980212074 @default.
• W4311472421 cites W1982076909 @default.
• W4311472421 cites W1995586545 @default.
• W4311472421 cites W2049776758 @default.
• W4311472421 cites W2053781426 @default.
• W4311472421 cites W2066234893 @default.
• W4311472421 cites W2091546373 @default.
• W4311472421 cites W2154555351 @default.
• W4311472421 cites W2167357429 @default.
• W4311472421 cites W2169678660 @default.
• W4311472421 cites W2237867856 @default.
• W4311472421 cites W2319963189 @default.
• W4311472421 cites W2413214158 @default.
• W4311472421 cites W2526011086 @default.
• W4311472421 cites W2549644842 @default.
• W4311472421 cites W2590936958 @default.
• W4311472421 cites W2600434382 @default.
• W4311472421 cites W2604084092 @default.
• W4311472421 cites W2604906306 @default.
• W4311472421 cites W2716684266 @default.
• W4311472421 cites W2750141062 @default.
• W4311472421 cites W2772065112 @default.
• W4311472421 cites W2801897467 @default.
• W4311472421 cites W2810718369 @default.
• W4311472421 cites W2914234341 @default.
• W4311472421 cites W2921104160 @default.
• W4311472421 cites W2936817325 @default.
• W4311472421 cites W2949484779 @default.
• W4311472421 cites W2954891553 @default.
• W4311472421 cites W2973160898 @default.
• W4311472421 cites W2982702030 @default.
• W4311472421 cites W2989901716 @default.
• W4311472421 cites W2999939693 @default.
• W4311472421 cites W3002917569 @default.
• W4311472421 cites W3015873223 @default.
• W4311472421 cites W3035155196 @default.
• W4311472421 cites W3042613436 @default.
• W4311472421 cites W3043105509 @default.
• W4311472421 cites W3047926305 @default.
• W4311472421 cites W3062970020 @default.
• W4311472421 cites W3091973262 @default.
• W4311472421 cites W3128646645 @default.
• W4311472421 cites W3134595554 @default.
• W4311472421 cites W3155166511 @default.
• W4311472421 cites W3168814517 @default.
• W4311472421 cites W3185273357 @default.
• W4311472421 cites W3191079335 @default.
• W4311472421 cites W3194480984 @default.
• W4311472421 cites W3211610290 @default.
• W4311472421 cites W4200135075 @default.
• W4311472421 cites W4200615556 @default.
• W4311472421 cites W4213183937 @default.
• W4311472421 cites W4220962778 @default.
• W4311472421 cites W4224278741 @default.
• W4311472421 cites W4224437032 @default.
• W4311472421 cites W4293375777 @default.
• W4311472421 cites W994255587 @default.
• W4311472421 doi "https://doi.org/10.2147/ijn.s387715" @default.
• W4311472421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36545220" @default.
• W4311472421 hasPublicationYear "2022" @default.
• W4311472421 type Work @default.
• W4311472421 citedByCount "1" @default.
• W4311472421 countsByYear W43114724212023 @default.
• W4311472421 crossrefType "journal-article" @default.
• W4311472421 hasAuthorship W4311472421A5004559394 @default.
• W4311472421 hasAuthorship W4311472421A5010892248 @default.
• W4311472421 hasAuthorship W4311472421A5018574064 @default.
• W4311472421 hasAuthorship W4311472421A5028296024 @default.
• W4311472421 hasAuthorship W4311472421A5030776673 @default.
• W4311472421 hasAuthorship W4311472421A5038635529 @default.
• W4311472421 hasAuthorship W4311472421A5040295342 @default.
• W4311472421 hasAuthorship W4311472421A5044525929 @default.
• W4311472421 hasAuthorship W4311472421A5050094963 @default.
• W4311472421 hasAuthorship W4311472421A5052776208 @default.
• W4311472421 hasAuthorship W4311472421A5056982346 @default.
• W4311472421 hasAuthorship W4311472421A5057729209 @default.
• W4311472421 hasAuthorship W4311472421A5066174435 @default.
• W4311472421 hasBestOaLocation W43114724211 @default.
• W4311472421 hasConcept C134018914 @default.

• next