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• W4311476463 abstract "Multiple sclerosis (MS) is a demyelinating disease of the central nervous system with unknown pathophysiology. Microglia and macrophages accumulate in MS lesions and are discussed as initiators of the cascade of demyelination. Demyelinating lesions can be found in other diseases of the CNS such as the autoimmune disease neuromyelitis optica (NMO) and the infection progressive multifocal leukencephalopathy (PML) caused by JC-virus. In the present study, cerebral paraffin sections of 30 autopsy cases with the diagnosis MS, 7 autopsy cases with NMO and 12 autopsy cases with PML as well as 16 control cases with rapidly fatal diseases without any evidence of an inflammatory CNS disease were stained by immunhistochemistry using the primary antibodies KiM1P, P2Y12, TMEM119 and CCR2. Stained sections were quantitatively asessed, and the relative frequencies of the different cells were compared by non-parametrical statistical methods. In comparison to normal white matter of control, NMO and PML cases, MS cases were characterized by an increased density of CCR2-positive inflammatory monocytes both in the peri-plaque white matter (PPWM) and in the normal appearing white matter (NAWM). CCR2-positive inflammatory monocytes were present in the lesions of NMO and MS, but not in the lesions of PML cases. KiM1P-positive activated microglial cells and macrophages accumulated in the lesions of MS, NMO and PML cases. In the NAWM of MS cases more KiM1P-positive activated microglia and macrophages were found than in control cases and in cases with other demyelinating diseases. In contrast to MS and control cases, the PPWM and NAWM of PML and NMO cases had a reduced density of TMEM119-positive microglial cells. The density of TMEM119-positive homoiostatic microglial cells was reduced in PML and NMO lesions and in inactive lesions of MS cases. A loss of homoiostatic P2Y12-positive microglial cells was observed in all three demyelinisating diseases studied in the lesions as well as in NAWM and PPWM. In MS, phagocytes originate both from the pool of microglia and from peripheral blood. In contrast to NMO and PML, we observed higher densities of inflammatory monocytes and activated microglia in the NAWM of MS cases than in the white matter of control cases. These results suggest severe inflammation in the NAWM and in the PPWM of MS patients." @default.
• W4311476463 created "2022-12-26" @default.
• W4311476463 creator A5089068437 @default.
• W4311476463 date "2022-12-14" @default.
• W4311476463 modified "2023-09-30" @default.
• W4311476463 title "Mikroglia-/Makrophagenphänotypen bei humanen Entmarkungserkrankungen (MS, NMO und PML)" @default.
• W4311476463 doi "https://doi.org/10.53846/goediss-9627" @default.
• W4311476463 hasPublicationYear "2022" @default.
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