FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311478013> ?p ?o ?g. }

• W4311478013 abstract "Understanding the natural microbiome and resistome of wildlife from remote places is necessary to monitor the human footprint on the environment including antimicrobial use (AU). Marine iguanas are endemic species from the Galapagos Islands where they are highly affected by anthropogenic factors that can alter their microbiota as well as their abundance and diversity of antimicrobial-resistant genes (ARGs). Thus, this study aims to apply culture-independent approaches to characterize the marine iguana's gut metagenomic composition of samples collected from the uninhabited islands Rabida (n = 8) and Fernandina (Cabo Douglas, n = 30; Punta Espinoza, n = 30). Fresh feces from marine iguanas were analyzed through SmartChip RT-PCR, 16S rRNA, and metagenomic next-generation sequencing (mNGS) to identify their microbiome, microbial-metabolic pathways, resistome, mobilome, and virulome.The marine iguana's gut microbiome composition was highly conserved despite differences in ecological niches, where 86% of taxa were shared in the three locations. However, site-specific differences were mainly identified in resistome, mobilome, virulorome, and metabolic pathway composition, highlighting the existence of factors that induce microbial adaptations in each location. Functional gut microbiome analyses revealed its role in the biosynthesis and degradation of vitamins, cofactors, proteinogenic amino acids, carbohydrates, nucleosides and nucleotides, fatty acids, lipids, and other compounds necessary for the marine iguanas. The overall bacterial ARG abundance was relatively low (0.006%); nevertheless, the presence of genes encoding resistance to 22 drug classes was identified in the iguana's gut metagenome. ARG-carrying contig and co-occurrence network analyses revealed that commensal bacteria are the main hosts of ARGs. Taxa of public health interest such as Salmonella, Vibrio, and Klebsiella also carried multidrug-resistance genes associated with MGEs which can influence the dissemination of ARGs through horizontal gene transfer.Marine iguanas depend on the gut microbiome for the biosynthesis and degradation of several compounds through a symbiotic relationship. Niche-specific adaptations were evidenced in the pool of microbial accessory genes (i.e., ARGs, MGEs, and virulence) and metabolic pathways, but not in the microbiome composition. Culture-independent approaches outlined the presence of a diverse resistome composition in the Galapagos marine iguanas from remote islands. The presence of AR pathogens in marine iguanas raises concerns about the dispersion of microbial-resistant threats in pristine areas, highlighting wildlife as sentinel species to identify the impact of AU." @default.
• W4311478013 created "2022-12-26" @default.
• W4311478013 creator A5000154835 @default.
• W4311478013 creator A5019682281 @default.
• W4311478013 creator A5046264445 @default.
• W4311478013 creator A5048971840 @default.
• W4311478013 creator A5067939471 @default.
• W4311478013 date "2022-12-14" @default.
• W4311478013 modified "2023-10-04" @default.
• W4311478013 title "Characterization of the gut microbiome and resistome of Galapagos marine iguanas (Amblyrhynchus cristatus) from uninhabited islands" @default.
• W4311478013 cites W1887284462 @default.
• W4311478013 cites W1924423433 @default.
• W4311478013 cites W1971605339 @default.
• W4311478013 cites W1974851910 @default.
• W4311478013 cites W1979912420 @default.
• W4311478013 cites W1994132622 @default.
• W4311478013 cites W2029576975 @default.
• W4311478013 cites W2033900229 @default.
• W4311478013 cites W2042298178 @default.
• W4311478013 cites W2050345155 @default.
• W4311478013 cites W2056279562 @default.
• W4311478013 cites W2060228740 @default.
• W4311478013 cites W2060607230 @default.
• W4311478013 cites W2064728879 @default.
• W4311478013 cites W2085926377 @default.
• W4311478013 cites W2095969400 @default.
• W4311478013 cites W2102461176 @default.
• W4311478013 cites W2103296919 @default.
• W4311478013 cites W2117457769 @default.
• W4311478013 cites W2119497560 @default.
• W4311478013 cites W2125910575 @default.
• W4311478013 cites W2128711701 @default.
• W4311478013 cites W2131271579 @default.
• W4311478013 cites W2134830426 @default.
• W4311478013 cites W2138252706 @default.
• W4311478013 cites W2143485490 @default.
• W4311478013 cites W2157025252 @default.
• W4311478013 cites W2170024099 @default.
• W4311478013 cites W2345658906 @default.
• W4311478013 cites W2401404581 @default.
• W4311478013 cites W2513506562 @default.
• W4311478013 cites W2518643713 @default.
• W4311478013 cites W2599417231 @default.
• W4311478013 cites W2613324804 @default.
• W4311478013 cites W2775235579 @default.
• W4311478013 cites W2810516221 @default.
• W4311478013 cites W2883609406 @default.
• W4311478013 cites W2951274106 @default.
• W4311478013 cites W2955802594 @default.
• W4311478013 cites W2963276645 @default.
• W4311478013 cites W2977283997 @default.
• W4311478013 cites W2977870980 @default.
• W4311478013 cites W2981413553 @default.
• W4311478013 cites W2990618091 @default.
• W4311478013 cites W3006176987 @default.
• W4311478013 cites W3037325942 @default.
• W4311478013 cites W3043062835 @default.
• W4311478013 cites W3128701120 @default.
• W4311478013 cites W3143063265 @default.
• W4311478013 cites W3159504416 @default.
• W4311478013 cites W3164653576 @default.
• W4311478013 cites W3166825720 @default.
• W4311478013 cites W3211779138 @default.
• W4311478013 cites W4206677002 @default.
• W4311478013 cites W4225864677 @default.
• W4311478013 cites W4242056892 @default.
• W4311478013 cites W4293446896 @default.
• W4311478013 doi "https://doi.org/10.1186/s42523-022-00218-4" @default.
• W4311478013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36517909" @default.
• W4311478013 hasPublicationYear "2022" @default.
• W4311478013 type Work @default.
• W4311478013 citedByCount "0" @default.
• W4311478013 crossrefType "journal-article" @default.
• W4311478013 hasAuthorship W4311478013A5000154835 @default.
• W4311478013 hasAuthorship W4311478013A5019682281 @default.
• W4311478013 hasAuthorship W4311478013A5046264445 @default.
• W4311478013 hasAuthorship W4311478013A5048971840 @default.
• W4311478013 hasAuthorship W4311478013A5067939471 @default.
• W4311478013 hasBestOaLocation W43114780131 @default.
• W4311478013 hasConcept C104317684 @default.
• W4311478013 hasConcept C143121216 @default.
• W4311478013 hasConcept C15151743 @default.
• W4311478013 hasConcept C18903297 @default.
• W4311478013 hasConcept C2776650774 @default.
• W4311478013 hasConcept C2776666601 @default.
• W4311478013 hasConcept C2777252401 @default.
• W4311478013 hasConcept C523546767 @default.
• W4311478013 hasConcept C539455810 @default.
• W4311478013 hasConcept C54355233 @default.
• W4311478013 hasConcept C55493867 @default.
• W4311478013 hasConcept C86803240 @default.
• W4311478013 hasConcept C90132467 @default.
• W4311478013 hasConcept C90856448 @default.
• W4311478013 hasConcept C94665300 @default.
• W4311478013 hasConcept C98722961 @default.
• W4311478013 hasConceptScore W4311478013C104317684 @default.
• W4311478013 hasConceptScore W4311478013C143121216 @default.
• W4311478013 hasConceptScore W4311478013C15151743 @default.
• W4311478013 hasConceptScore W4311478013C18903297 @default.
• W4311478013 hasConceptScore W4311478013C2776650774 @default.

• next