Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311486510> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W4311486510 abstract "<p> </p> <p><em>Objective</em></p> <p>Analyse the impact of modern glucose-monitoring strategies on glycemic and patient-related outcomes in individuals with type 2 diabetes (T2D) and recent myocardial infarction (MI), and also assess cost effectiveness. </p> <p><em>Research design and methods</em></p> <p>LIBERATES was a multicentre, two-arm randomised trial comparing self-monitoring of blood glucose (SMBG) with intermittently scanned continuous glucose monitoring (isCGM), also known as flash CGM, in individuals with T2D and recent MI, treated with insulin and/or sulphonylurea prior to hospital admission. </p> <p>The primary outcome measure was time in range (TIR; glucose 3.9-10 mmol/l)/day on days 76-90 post randomisation. Secondary and exploratory outcomes included time in hypoglycemia, hemoglobin (Hb)A1c, clinical outcome, quality of life (QoL) and cost effectiveness. </p> <p><em>Results </em></p> <p>Of 141 participants aged [median 63 IQR (53, 70) years, 73% males] randomised, isCGM was associated with increased TIR by 17mins/day (95% credible interval -105, +153mins/day) with 59% probability for a benefit. Users of isCGM showed lower hypoglycemic exposure (<3.9 mmol/l) at days 76-90 [-80min/day (95% CI: -118, -43)], also evident at days 16-30 [-28min/day (-92, 2)]. Compared with baseline, HbA1c showed similar reductions of 7 mmol/mol at 3 months in both study arms. </p> <p>Combined glycemic emergencies/mortality occurred in 4 isCGM and 7 SMBG study participants. QoL measures marginally favoured isCGM and the intervention proved to be cost-effective. </p> <p><em>Conclusions</em></p> <p>Compared with SMBG, isCGM in T2D individuals with MI marginally increases TIR and significantly reduces hypoglycemic exposure while equally improving HbA1c, explaining its cost-effectiveness. Studies are required to understand whether these glycemic differences translate into longer term clinical benefit. </p>" @default.
- W4311486510 created "2022-12-26" @default.
- W4311486510 creator A5000995267 @default.
- W4311486510 creator A5004717026 @default.
- W4311486510 creator A5006979396 @default.
- W4311486510 creator A5015571578 @default.
- W4311486510 creator A5020250464 @default.
- W4311486510 creator A5023057149 @default.
- W4311486510 creator A5041477606 @default.
- W4311486510 creator A5050694469 @default.
- W4311486510 creator A5052889466 @default.
- W4311486510 creator A5062170233 @default.
- W4311486510 creator A5069178914 @default.
- W4311486510 creator A5071271395 @default.
- W4311486510 creator A5086223086 @default.
- W4311486510 creator A5089910248 @default.
- W4311486510 date "2022-12-14" @default.
- W4311486510 modified "2023-10-14" @default.
- W4311486510 title "Multicenter Randomized Trial of Intermittently Scanned Continuous Glucose Monitoring Versus Self-Monitoring of Blood Glucose in Individuals With Type 2 Diabetes and Recent-Onset Acute Myocardial Infarction: Results of the LIBERATES Trial" @default.
- W4311486510 doi "https://doi.org/10.2337/figshare.21496824" @default.
- W4311486510 hasPublicationYear "2022" @default.
- W4311486510 type Work @default.
- W4311486510 citedByCount "0" @default.
- W4311486510 crossrefType "posted-content" @default.
- W4311486510 hasAuthorship W4311486510A5000995267 @default.
- W4311486510 hasAuthorship W4311486510A5004717026 @default.
- W4311486510 hasAuthorship W4311486510A5006979396 @default.
- W4311486510 hasAuthorship W4311486510A5015571578 @default.
- W4311486510 hasAuthorship W4311486510A5020250464 @default.
- W4311486510 hasAuthorship W4311486510A5023057149 @default.
- W4311486510 hasAuthorship W4311486510A5041477606 @default.
- W4311486510 hasAuthorship W4311486510A5050694469 @default.
- W4311486510 hasAuthorship W4311486510A5052889466 @default.
- W4311486510 hasAuthorship W4311486510A5062170233 @default.
- W4311486510 hasAuthorship W4311486510A5069178914 @default.
- W4311486510 hasAuthorship W4311486510A5071271395 @default.
- W4311486510 hasAuthorship W4311486510A5086223086 @default.
- W4311486510 hasAuthorship W4311486510A5089910248 @default.
- W4311486510 hasBestOaLocation W43114865101 @default.
- W4311486510 hasConcept C126322002 @default.
- W4311486510 hasConcept C134018914 @default.
- W4311486510 hasConcept C168563851 @default.
- W4311486510 hasConcept C2777180221 @default.
- W4311486510 hasConcept C2779306644 @default.
- W4311486510 hasConcept C2780473172 @default.
- W4311486510 hasConcept C2780668416 @default.
- W4311486510 hasConcept C2781232474 @default.
- W4311486510 hasConcept C2986379492 @default.
- W4311486510 hasConcept C500558357 @default.
- W4311486510 hasConcept C555293320 @default.
- W4311486510 hasConcept C71924100 @default.
- W4311486510 hasConcept C90924648 @default.
- W4311486510 hasConceptScore W4311486510C126322002 @default.
- W4311486510 hasConceptScore W4311486510C134018914 @default.
- W4311486510 hasConceptScore W4311486510C168563851 @default.
- W4311486510 hasConceptScore W4311486510C2777180221 @default.
- W4311486510 hasConceptScore W4311486510C2779306644 @default.
- W4311486510 hasConceptScore W4311486510C2780473172 @default.
- W4311486510 hasConceptScore W4311486510C2780668416 @default.
- W4311486510 hasConceptScore W4311486510C2781232474 @default.
- W4311486510 hasConceptScore W4311486510C2986379492 @default.
- W4311486510 hasConceptScore W4311486510C500558357 @default.
- W4311486510 hasConceptScore W4311486510C555293320 @default.
- W4311486510 hasConceptScore W4311486510C71924100 @default.
- W4311486510 hasConceptScore W4311486510C90924648 @default.
- W4311486510 hasLocation W43114865101 @default.
- W4311486510 hasLocation W43114865102 @default.
- W4311486510 hasLocation W43114865103 @default.
- W4311486510 hasLocation W43114865104 @default.
- W4311486510 hasOpenAccess W4311486510 @default.
- W4311486510 hasPrimaryLocation W43114865101 @default.
- W4311486510 hasRelatedWork W1873435453 @default.
- W4311486510 hasRelatedWork W2017030704 @default.
- W4311486510 hasRelatedWork W2071740101 @default.
- W4311486510 hasRelatedWork W2095240021 @default.
- W4311486510 hasRelatedWork W2781585919 @default.
- W4311486510 hasRelatedWork W2971713860 @default.
- W4311486510 hasRelatedWork W3030910522 @default.
- W4311486510 hasRelatedWork W3126557659 @default.
- W4311486510 hasRelatedWork W3164469103 @default.
- W4311486510 hasRelatedWork W4309510666 @default.
- W4311486510 isParatext "false" @default.
- W4311486510 isRetracted "false" @default.
- W4311486510 workType "article" @default.