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- W4311488162 abstract "Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) has been identified as a nuclear DNA sensor. Upon viral infection, hnRNP A2/B1 recognizes pathogen-derived DNA as a homodimer, which is a prerequisite for its translocation to the cytoplasm to activate the interferon response. However, the DNA binding mechanism inducing hnRNP A2/B1 homodimerization is unknown. Here, we show the crystal structure of the RNA recognition motif (RRM) of hnRNP A2/B1 in complex with a U-shaped ssDNA, which mediates the formation of a newly observed protein dimer. Our biochemical assays and mutagenesis studies confirm that the hnRNP A2/B1 homodimer forms in solution by binding to pre-generated ssDNA or dsDNA with a U-shaped bulge. These results depict a potential functional state of hnRNP A2/B1 in antiviral immunity and other cellular processes." @default.
- W4311488162 created "2022-12-26" @default.
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- W4311488162 date "2023-02-01" @default.
- W4311488162 modified "2023-10-01" @default.
- W4311488162 title "Structural Insight Into hnRNP A2/B1 Homodimerization and DNA Recognition" @default.
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- W4311488162 doi "https://doi.org/10.1016/j.jmb.2022.167920" @default.
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