FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311489103> ?p ?o ?g. }

• W4311489103 endingPage "106993" @default.
• W4311489103 startingPage "106993" @default.
• W4311489103 abstract "Melittin (MLT) treatment is believed to enhance tumor cell death, apoptotic, and oxidative cytotoxic effects of cisplatin (CSP) via the modulation of Ca2+ channels in several cancer lines. The activation of TRPM2 mediated anticancer and CSP resistance actions via mitochondrial Ca2+ and Zn2+ accumulation-induced mitochondrial reactive free oxygen species (MitSOX) in the glioblastoma cells. The aim was to elucidate the effects of CSP and MLT combination via the TRPM2 stimulation on the tumor cell viability, cell number, cell death (propidium iodide/Hoechst rate), apoptosis, and MitSOX levels in the DBTRG-05MG cells. In the DBTRG-05MG cells, we induced four groups as control, MLT (2.5 μg/ml for 24 h), CSP (25 μM for 24 h), and CSP + MLT. The CSP-induced intracellular Ca2+ influxes to the TRPM2 activation were increased in the cells from coming H2O2 and ADP-Ribose. The influxes were decreased in the cells by the incubations of TRPM2 antagonists (ACA and carvacrol). The incubation of CSP increased the parameters of intracellular Ca2+ responses, mitochondria function, cytosolic free Zn2+ accumulation, apoptosis (caspase -3, -8, and -9), and MitSOX generation in the tumor cells. After the treatment of MLT with/without CSP, the parameters were further increased in the cells. In conclusion, the treatment of MLT increased the anticancer, tumor cell death, apoptotic, and oxidant effects of CSP in the glioblastoma tumor cells via activating the TRPM2. As a result, TRPM2 stimulation by MLT may be utilized as a successful agent in the CSP treatment of glioblastoma tumors." @default.
• W4311489103 created "2022-12-26" @default.
• W4311489103 creator A5015317989 @default.
• W4311489103 creator A5058085364 @default.
• W4311489103 date "2023-01-01" @default.
• W4311489103 modified "2023-10-03" @default.
• W4311489103 title "Honey bee venom melittin increases the oxidant activity of cisplatin and kills human glioblastoma cells by stimulating the TRPM2 channel" @default.
• W4311489103 cites W1537218374 @default.
• W4311489103 cites W1542697059 @default.
• W4311489103 cites W1969246107 @default.
• W4311489103 cites W1972919992 @default.
• W4311489103 cites W1977412637 @default.
• W4311489103 cites W1997319312 @default.
• W4311489103 cites W2005364830 @default.
• W4311489103 cites W2014100516 @default.
• W4311489103 cites W2015063933 @default.
• W4311489103 cites W2059176681 @default.
• W4311489103 cites W2080499350 @default.
• W4311489103 cites W2090055520 @default.
• W4311489103 cites W2119589189 @default.
• W4311489103 cites W2129648100 @default.
• W4311489103 cites W2167318614 @default.
• W4311489103 cites W2169931629 @default.
• W4311489103 cites W2325336945 @default.
• W4311489103 cites W2334738758 @default.
• W4311489103 cites W2342740677 @default.
• W4311489103 cites W2525089519 @default.
• W4311489103 cites W2605875091 @default.
• W4311489103 cites W2871417476 @default.
• W4311489103 cites W2904721919 @default.
• W4311489103 cites W2915611308 @default.
• W4311489103 cites W2922329892 @default.
• W4311489103 cites W2991033820 @default.
• W4311489103 cites W2999453758 @default.
• W4311489103 cites W3005497787 @default.
• W4311489103 cites W3006066357 @default.
• W4311489103 cites W3041446556 @default.
• W4311489103 cites W3117305835 @default.
• W4311489103 cites W3120977085 @default.
• W4311489103 cites W3127136991 @default.
• W4311489103 cites W3162360608 @default.
• W4311489103 cites W3197930205 @default.
• W4311489103 cites W4206987130 @default.
• W4311489103 cites W4207048700 @default.
• W4311489103 cites W4223646189 @default.
• W4311489103 cites W4225709695 @default.
• W4311489103 doi "https://doi.org/10.1016/j.toxicon.2022.106993" @default.
• W4311489103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36528210" @default.
• W4311489103 hasPublicationYear "2023" @default.
• W4311489103 type Work @default.
• W4311489103 citedByCount "3" @default.
• W4311489103 countsByYear W43114891032023 @default.
• W4311489103 crossrefType "journal-article" @default.
• W4311489103 hasAuthorship W4311489103A5015317989 @default.
• W4311489103 hasAuthorship W4311489103A5058085364 @default.
• W4311489103 hasConcept C121608353 @default.
• W4311489103 hasConcept C151495721 @default.
• W4311489103 hasConcept C154317977 @default.
• W4311489103 hasConcept C155164980 @default.
• W4311489103 hasConcept C170493617 @default.
• W4311489103 hasConcept C190283241 @default.
• W4311489103 hasConcept C202751555 @default.
• W4311489103 hasConcept C2775934118 @default.
• W4311489103 hasConcept C2778001312 @default.
• W4311489103 hasConcept C2779281246 @default.
• W4311489103 hasConcept C28859421 @default.
• W4311489103 hasConcept C31573885 @default.
• W4311489103 hasConcept C48349386 @default.
• W4311489103 hasConcept C502942594 @default.
• W4311489103 hasConcept C53227056 @default.
• W4311489103 hasConcept C54355233 @default.
• W4311489103 hasConcept C55493867 @default.
• W4311489103 hasConcept C79879829 @default.
• W4311489103 hasConcept C86803240 @default.
• W4311489103 hasConcept C95444343 @default.
• W4311489103 hasConcept C96232424 @default.
• W4311489103 hasConcept C98274493 @default.
• W4311489103 hasConceptScore W4311489103C121608353 @default.
• W4311489103 hasConceptScore W4311489103C151495721 @default.
• W4311489103 hasConceptScore W4311489103C154317977 @default.
• W4311489103 hasConceptScore W4311489103C155164980 @default.
• W4311489103 hasConceptScore W4311489103C170493617 @default.
• W4311489103 hasConceptScore W4311489103C190283241 @default.
• W4311489103 hasConceptScore W4311489103C202751555 @default.
• W4311489103 hasConceptScore W4311489103C2775934118 @default.
• W4311489103 hasConceptScore W4311489103C2778001312 @default.
• W4311489103 hasConceptScore W4311489103C2779281246 @default.
• W4311489103 hasConceptScore W4311489103C28859421 @default.
• W4311489103 hasConceptScore W4311489103C31573885 @default.
• W4311489103 hasConceptScore W4311489103C48349386 @default.
• W4311489103 hasConceptScore W4311489103C502942594 @default.
• W4311489103 hasConceptScore W4311489103C53227056 @default.
• W4311489103 hasConceptScore W4311489103C54355233 @default.
• W4311489103 hasConceptScore W4311489103C55493867 @default.
• W4311489103 hasConceptScore W4311489103C79879829 @default.
• W4311489103 hasConceptScore W4311489103C86803240 @default.
• W4311489103 hasConceptScore W4311489103C95444343 @default.
• W4311489103 hasConceptScore W4311489103C96232424 @default.

• next