FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311502021> ?p ?o ?g. }

• W4311502021 endingPage "820" @default.
• W4311502021 startingPage "813" @default.
• W4311502021 abstract "Objective: To study the changes of serum metabolic profile of occupational people exposed with nanometer titanium dioxide particles (TiO(2)-NPs), and to explore the biomarkers and injury mechanism of TiO(2)-NPs health effects. Methods: From June 2020 to June 2021, a TiO(2)-NPs production enterprise was selected as the research site by a typical sampling method, 64 people in the TiO(2)-NPs exposure group were selected from the enterprise, and 62 people of the logistics administrative staff in the same enterprise were selected as the control group, and blood samples were collected using non-anticoagulant blood collection tubes. After the samples were methanol-precipitated, the untargeted metabolomic data was collected by ultra-high performance liquid chromatography time-of-flight mass spectrometry, and biomarkers were screened and metabolic pathway analysis was performed. Results: 46 different metabolites were screened out by P<0.05 and variable importance projection index (VIP) value >1, mainly including glycerides, sphingomyelin, glycerophospholipid, fatty acyl, etc.; By ROC analysis to determine 3-hydroxy-4, 5-dimethyl-2 (5H) - furanone, 4-aminobiphenyl, heptanoylcarnitine, Hexadecanedioic acid mono-L-carnitine ester, Ibutilide, LysoPA (18∶1 (9Z) /0∶0), LysoPC (18∶0), PC (16∶0/16∶0), PC (16∶0/20: 4 (5Z, 8Z, 11Z, 14Z) ), PC (P-18∶1 (9Z) /P-18∶1 (9Z) ) 10 candidate biomarkers; involving changes in 4 metabolic pathways, namely glycerophospholipid metabolism, sphingolipid metabolism, phenylalanine, tyrosine and tryptophan acid biosynthesis, linoleic acid metabolism. Conclusion: Occupational exposure to TiO(2)-NPs has a significant impact on serum metabolic profiles.目的： 研究纳米二氧化钛颗粒（TiO(2)-NPs）职业暴露人群血清代谢谱变化，探索TiO(2)-NPs健康效应的生物标志物和损伤机制。 方法： 于2020年6月至2021年6月，通过典型抽样的方法选取某TiO(2)-NPs生产企业职工为研究对象，从企业中选取接触TiO(2)-NPs工人64人为暴露组，选取同企业后勤行政人员62人为对照组，使用非抗凝采血管收集血样。样品经甲醇沉淀蛋白后采用超高效液相色谱飞行时间质谱技术采集非靶向代谢组学数据，筛选生物标志物并进行代谢通路分析。 结果： 通过P<0.05和变量重要性投影指标（VIP）值>1两个指标筛选出46个差异代谢物，主要包括甘油酯类、鞘磷脂类、甘油磷脂类、脂肪酰基类等；通过受试者工作曲线（ROC）分析确定3-羟基-4，5-二甲基-2（5H）-呋喃酮、4-氨基联苯、庚酰肉碱、十六烷二酸单-L-肉碱酯、伊布利特、LysoPA[18∶1（9Z）/0∶0]、LysoPC（18∶0）、PC（16∶0/16∶0）、PC[16∶0/20∶4（5Z，8Z，11Z，14Z）]、PC[P-18∶1（9Z）/P-18∶1（9Z）]10个候选生物标志物；涉及4条代谢通路的变化，分别为甘油磷脂代谢，鞘脂代谢，苯丙氨酸、酪氨酸和色氨酸的生物合成，亚油酸代谢。 结论： TiO(2)-NPs职业暴露会对血清代谢谱产生明显影响。." @default.
• W4311502021 created "2022-12-26" @default.
• W4311502021 creator A5002894058 @default.
• W4311502021 creator A5015416778 @default.
• W4311502021 creator A5021277110 @default.
• W4311502021 creator A5075726392 @default.
• W4311502021 creator A5084921767 @default.
• W4311502021 date "2022-11-20" @default.
• W4311502021 modified "2023-10-17" @default.
• W4311502021 title "[A non-targeted metabolomics study on serum of occupational people exposed with nanometer titanium dioxide particles (TiO(2)-NPs)]." @default.
• W4311502021 doi "https://doi.org/10.3760/cma.j.cn121094-20210318-00158" @default.
• W4311502021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36510714" @default.
• W4311502021 hasPublicationYear "2022" @default.
• W4311502021 type Work @default.
• W4311502021 citedByCount "0" @default.
• W4311502021 crossrefType "journal-article" @default.
• W4311502021 hasAuthorship W4311502021A5002894058 @default.
• W4311502021 hasAuthorship W4311502021A5015416778 @default.
• W4311502021 hasAuthorship W4311502021A5021277110 @default.
• W4311502021 hasAuthorship W4311502021A5075726392 @default.
• W4311502021 hasAuthorship W4311502021A5084921767 @default.
• W4311502021 hasConcept C185592680 @default.
• W4311502021 hasConcept C200514077 @default.
• W4311502021 hasConcept C21565614 @default.
• W4311502021 hasConcept C2776952329 @default.
• W4311502021 hasConcept C2778918659 @default.
• W4311502021 hasConcept C41625074 @default.
• W4311502021 hasConcept C43617362 @default.
• W4311502021 hasConcept C543025807 @default.
• W4311502021 hasConcept C55493867 @default.
• W4311502021 hasConcept C62231903 @default.
• W4311502021 hasConceptScore W4311502021C185592680 @default.
• W4311502021 hasConceptScore W4311502021C200514077 @default.
• W4311502021 hasConceptScore W4311502021C21565614 @default.
• W4311502021 hasConceptScore W4311502021C2776952329 @default.
• W4311502021 hasConceptScore W4311502021C2778918659 @default.
• W4311502021 hasConceptScore W4311502021C41625074 @default.
• W4311502021 hasConceptScore W4311502021C43617362 @default.
• W4311502021 hasConceptScore W4311502021C543025807 @default.
• W4311502021 hasConceptScore W4311502021C55493867 @default.
• W4311502021 hasConceptScore W4311502021C62231903 @default.
• W4311502021 hasIssue "11" @default.
• W4311502021 hasLocation W43115020211 @default.
• W4311502021 hasOpenAccess W4311502021 @default.
• W4311502021 hasPrimaryLocation W43115020211 @default.
• W4311502021 hasRelatedWork W1540914409 @default.
• W4311502021 hasRelatedWork W1761593742 @default.
• W4311502021 hasRelatedWork W2048465125 @default.
• W4311502021 hasRelatedWork W2082877035 @default.
• W4311502021 hasRelatedWork W2286148362 @default.
• W4311502021 hasRelatedWork W2295221742 @default.
• W4311502021 hasRelatedWork W2789487828 @default.
• W4311502021 hasRelatedWork W2945629678 @default.
• W4311502021 hasRelatedWork W3128550852 @default.
• W4311502021 hasRelatedWork W4304585189 @default.
• W4311502021 hasVolume "40" @default.
• W4311502021 isParatext "false" @default.
• W4311502021 isRetracted "false" @default.
• W4311502021 workType "article" @default.