Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311504920> ?p ?o ?g. }
- W4311504920 abstract "Background Neuropsychiatric symptoms (NPSs) belong to a category of non-motor symptoms of Parkinson's disease (PD), which seriously compromise the quality of life and prognosis of PD. This study focused on the correlations between NPSs, free radicals, neuroinflammatory factors, and neuropathological proteins in cerebrospinal fluid (CSF) in patients with PD, aiming to provide insights into the potential mechanisms and therapeutic target for PD with NPSs (PD-NPSs). Methods In total, 129 patients with PD were enrolled and assessed by the Neuropsychiatric Symptoms Inventory (NPI); they were divided into the PD-NPSs group (75 patients) and PD with no NPSs (PD-nNPSs) group (54 patients). The levels of hydrogen peroxide (H 2 O 2 ) and nitric oxide (NO), and hydroxyl radical (·OH), anti-oxidative enzyme, neuroinflammatory factors, and neuropathological proteins in CSF from patients with PD were measured. The levels of the above variables were compared between PD-NPSs and PD-nNPSs groups, and correlation analyses among the above variables were conducted. Results (1) The levels of H 2 O 2 and NO in CSF from the PD-NPSs group were significantly elevated compared with the PD-nNPSs group ( p = 0.001), and NPI score positively correlated with the levels of H 2 O 2 and NO ( r = 0.283, P = 0.001; r = 0.231, P = 0.008). Reversely, total superoxide dismutase (tSOD) activity in CSF from the PD-NPSs group was significantly reduced compared with the PD-nNPSs group ( p = 0.011), and negatively correlated with NPI score ( r = −0.185, p = 0.036). (2) The tumor necrosis factor (TNF)-α level in CSF from the PD-NPSs group was significantly decreased compared with the PD-nNPSs group ( p = 0.002) and negatively correlated with NPI score ( r = −0.211, p = 0.016). (3) The total tau (T-tau) level in CSF from the PD-NPSs group was significantly higher than in the PD-nNPSs group ( p = 0.014) and positively correlated with the NPI score ( r = 0.167, p = 0.060). (4) The levels of H 2 O 2 and NO positively correlated with the T-tau level in CSF from the PD-NPSs group ( r = 0.183, p = 0.039; r = 0.251, P = 0.004), and the levels of TNF-α and T-tau showed a negative correlation ( r = −0.163, p = 0.067). Conclusion Oxidative distress characterized by the elevations of H 2 O 2 and NO levels may closely correlate with the neurodegeneration in brain regions related to PD-NPSs. Thus, therapeutic antioxidants may become an important target for PD-NPSs therapy." @default.
- W4311504920 created "2022-12-26" @default.
- W4311504920 creator A5019736792 @default.
- W4311504920 creator A5022330902 @default.
- W4311504920 creator A5041833203 @default.
- W4311504920 creator A5047926904 @default.
- W4311504920 creator A5048668483 @default.
- W4311504920 creator A5055875257 @default.
- W4311504920 creator A5059352135 @default.
- W4311504920 creator A5060640583 @default.
- W4311504920 creator A5068851817 @default.
- W4311504920 creator A5074840407 @default.
- W4311504920 creator A5076326299 @default.
- W4311504920 creator A5076699095 @default.
- W4311504920 creator A5087838135 @default.
- W4311504920 date "2022-12-15" @default.
- W4311504920 modified "2023-10-12" @default.
- W4311504920 title "Potential roles of oxidative distress on neurodegeneration in Parkinson's disease with neuropsychiatric symptoms" @default.
- W4311504920 cites W1480429336 @default.
- W4311504920 cites W1599125739 @default.
- W4311504920 cites W1826105565 @default.
- W4311504920 cites W1830806030 @default.
- W4311504920 cites W1876158137 @default.
- W4311504920 cites W1965400322 @default.
- W4311504920 cites W1975282106 @default.
- W4311504920 cites W1976599392 @default.
- W4311504920 cites W1987004867 @default.
- W4311504920 cites W1992791394 @default.
- W4311504920 cites W1999514395 @default.
- W4311504920 cites W2004100841 @default.
- W4311504920 cites W2034026137 @default.
- W4311504920 cites W2036643788 @default.
- W4311504920 cites W2038158623 @default.
- W4311504920 cites W2047819781 @default.
- W4311504920 cites W2058912318 @default.
- W4311504920 cites W2059502417 @default.
- W4311504920 cites W2065086442 @default.
- W4311504920 cites W2069650508 @default.
- W4311504920 cites W2071754987 @default.
- W4311504920 cites W2075050732 @default.
- W4311504920 cites W2080212310 @default.
- W4311504920 cites W2091889489 @default.
- W4311504920 cites W2094043851 @default.
- W4311504920 cites W2105032713 @default.
- W4311504920 cites W2112455323 @default.
- W4311504920 cites W2114654653 @default.
- W4311504920 cites W2118502552 @default.
- W4311504920 cites W2125882930 @default.
- W4311504920 cites W2134872741 @default.
- W4311504920 cites W2143325578 @default.
- W4311504920 cites W2151025194 @default.
- W4311504920 cites W2153879353 @default.
- W4311504920 cites W2230505097 @default.
- W4311504920 cites W2283069867 @default.
- W4311504920 cites W2332426211 @default.
- W4311504920 cites W2342102295 @default.
- W4311504920 cites W2344074899 @default.
- W4311504920 cites W2549336896 @default.
- W4311504920 cites W2572710398 @default.
- W4311504920 cites W2616097542 @default.
- W4311504920 cites W2618767189 @default.
- W4311504920 cites W2811401928 @default.
- W4311504920 cites W2884755749 @default.
- W4311504920 cites W2885966505 @default.
- W4311504920 cites W2923761317 @default.
- W4311504920 cites W2947181157 @default.
- W4311504920 cites W2951348834 @default.
- W4311504920 cites W2998480310 @default.
- W4311504920 cites W3042580583 @default.
- W4311504920 cites W3093531670 @default.
- W4311504920 cites W3096278723 @default.
- W4311504920 cites W3113036728 @default.
- W4311504920 cites W3176818973 @default.
- W4311504920 doi "https://doi.org/10.3389/fnagi.2022.875059" @default.
- W4311504920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36589540" @default.
- W4311504920 hasPublicationYear "2022" @default.
- W4311504920 type Work @default.
- W4311504920 citedByCount "1" @default.
- W4311504920 countsByYear W43115049202023 @default.
- W4311504920 crossrefType "journal-article" @default.
- W4311504920 hasAuthorship W4311504920A5019736792 @default.
- W4311504920 hasAuthorship W4311504920A5022330902 @default.
- W4311504920 hasAuthorship W4311504920A5041833203 @default.
- W4311504920 hasAuthorship W4311504920A5047926904 @default.
- W4311504920 hasAuthorship W4311504920A5048668483 @default.
- W4311504920 hasAuthorship W4311504920A5055875257 @default.
- W4311504920 hasAuthorship W4311504920A5059352135 @default.
- W4311504920 hasAuthorship W4311504920A5060640583 @default.
- W4311504920 hasAuthorship W4311504920A5068851817 @default.
- W4311504920 hasAuthorship W4311504920A5074840407 @default.
- W4311504920 hasAuthorship W4311504920A5076326299 @default.
- W4311504920 hasAuthorship W4311504920A5076699095 @default.
- W4311504920 hasAuthorship W4311504920A5087838135 @default.
- W4311504920 hasBestOaLocation W43115049201 @default.
- W4311504920 hasConcept C126322002 @default.
- W4311504920 hasConcept C2775838275 @default.
- W4311504920 hasConcept C2776151105 @default.
- W4311504920 hasConcept C2776925932 @default.
- W4311504920 hasConcept C2779134260 @default.
- W4311504920 hasConcept C2779651940 @default.