FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311518761> ?p ?o ?g. }

• W4311518761 endingPage "1658" @default.
• W4311518761 startingPage "1658" @default.
• W4311518761 abstract "(1) Objective: Resting-state fMRI studies have indicated that juvenile myoclonic epilepsy (JME) could cause widespread functional connectivity disruptions between the cerebrum and cerebellum. However, the directed influences or effective connectivities (ECs) between these brain regions are poorly understood. In the current study, we aimed to evaluate the ECs between the cerebrum and cerebellum in patients with new-onset JME. (2) Methods: Thirty-four new-onset JME patients and thirty-four age-, sex-, and education-matched healthy controls (HCs) were included in this study. We compared the degree centrality (DC) between the two groups to identify intergroup differences in whole-brain functional connectivity. Then, we used a Granger causality analysis (GCA) to explore JME-caused changes in EC between cerebrum regions and cerebellum regions. Furthermore, we applied a correlation analysis to identify associations between aberrant EC and disease severity in patients with JME. (3) Results: Compared to HCs, patients with JME showed significantly increased DC in the left cerebellum posterior lobe (CePL.L), the right inferior temporal gyrus (ITG.R) and the right superior frontal gyrus (SFG.R), and decreased DC in the left inferior frontal gyrus (IFG.L) and the left superior temporal gyrus (STG.L). The patients also showed unidirectionally increased ECs from cerebellum regions to the cerebrum regions, including from the CePL.L to the right precuneus (PreCU.R), from the left cerebellum anterior lobe (CeAL.L) to the ITG.R, from the right cerebellum posterior lobe (CePL.R) to the IFG.L, and from the left inferior semi-lunar lobule of the cerebellum (CeISL.L) to the SFG.R. Additionally, the EC from the CeISL.L to the SFG.R was negatively correlated with the disease severity. (4) Conclusions: JME patients showed unidirectional EC disruptions from the cerebellum to the cerebrum, and the negative correlation between EC and disease severity provides a new perspective for understanding the cerebro-cerebellar neural circuit mechanisms in JME." @default.
• W4311518761 created "2022-12-26" @default.
• W4311518761 creator A5002526161 @default.
• W4311518761 creator A5010844097 @default.
• W4311518761 creator A5042241049 @default.
• W4311518761 creator A5046560835 @default.
• W4311518761 creator A5049614818 @default.
• W4311518761 creator A5058811939 @default.
• W4311518761 creator A5066863522 @default.
• W4311518761 creator A5077558876 @default.
• W4311518761 creator A5086625918 @default.
• W4311518761 creator A5091539416 @default.
• W4311518761 date "2022-12-03" @default.
• W4311518761 modified "2023-10-13" @default.
• W4311518761 title "Altered Cerebro-Cerebellar Effective Connectivity in New-Onset Juvenile Myoclonic Epilepsy" @default.
• W4311518761 cites W1948150292 @default.
• W4311518761 cites W1980276616 @default.
• W4311518761 cites W1989436652 @default.
• W4311518761 cites W1991666932 @default.
• W4311518761 cites W1998633617 @default.
• W4311518761 cites W1998636255 @default.
• W4311518761 cites W2001584525 @default.
• W4311518761 cites W2005476331 @default.
• W4311518761 cites W2012242062 @default.
• W4311518761 cites W2015303758 @default.
• W4311518761 cites W2015576660 @default.
• W4311518761 cites W2019930104 @default.
• W4311518761 cites W2024994297 @default.
• W4311518761 cites W2057550180 @default.
• W4311518761 cites W2063497316 @default.
• W4311518761 cites W2064438454 @default.
• W4311518761 cites W2075476930 @default.
• W4311518761 cites W2077208375 @default.
• W4311518761 cites W2078204079 @default.
• W4311518761 cites W2091226020 @default.
• W4311518761 cites W2097982135 @default.
• W4311518761 cites W2107754490 @default.
• W4311518761 cites W2112476814 @default.
• W4311518761 cites W2114231389 @default.
• W4311518761 cites W2126650951 @default.
• W4311518761 cites W2126716971 @default.
• W4311518761 cites W2135147613 @default.
• W4311518761 cites W2135176444 @default.
• W4311518761 cites W2136199096 @default.
• W4311518761 cites W2145664048 @default.
• W4311518761 cites W2153612166 @default.
• W4311518761 cites W2164663881 @default.
• W4311518761 cites W2171903235 @default.
• W4311518761 cites W2270459920 @default.
• W4311518761 cites W2316162229 @default.
• W4311518761 cites W2323389528 @default.
• W4311518761 cites W2337052313 @default.
• W4311518761 cites W2463065595 @default.
• W4311518761 cites W2466828199 @default.
• W4311518761 cites W2480023557 @default.
• W4311518761 cites W2511244507 @default.
• W4311518761 cites W2557960740 @default.
• W4311518761 cites W2592509339 @default.
• W4311518761 cites W2606214056 @default.
• W4311518761 cites W2625054621 @default.
• W4311518761 cites W2773502023 @default.
• W4311518761 cites W2793006399 @default.
• W4311518761 cites W2880775462 @default.
• W4311518761 cites W2895387853 @default.
• W4311518761 cites W2898022217 @default.
• W4311518761 cites W2899900491 @default.
• W4311518761 cites W2912072511 @default.
• W4311518761 cites W2914251233 @default.
• W4311518761 cites W2921201789 @default.
• W4311518761 cites W2933775295 @default.
• W4311518761 cites W2944088065 @default.
• W4311518761 cites W2944955828 @default.
• W4311518761 cites W2948032838 @default.
• W4311518761 cites W2971893337 @default.
• W4311518761 cites W2990500979 @default.
• W4311518761 cites W2990748730 @default.
• W4311518761 cites W2996750224 @default.
• W4311518761 cites W3005257798 @default.
• W4311518761 cites W3006025189 @default.
• W4311518761 cites W3009968023 @default.
• W4311518761 cites W3014038732 @default.
• W4311518761 cites W3027262401 @default.
• W4311518761 cites W3046586182 @default.
• W4311518761 cites W3049290596 @default.
• W4311518761 cites W3083017933 @default.
• W4311518761 cites W3085222255 @default.
• W4311518761 cites W3118168011 @default.
• W4311518761 cites W3120616880 @default.
• W4311518761 cites W3151886197 @default.
• W4311518761 cites W3154487493 @default.
• W4311518761 cites W3157332358 @default.
• W4311518761 cites W3164700944 @default.
• W4311518761 cites W3164835367 @default.
• W4311518761 cites W3200420938 @default.
• W4311518761 cites W4213054604 @default.
• W4311518761 cites W4231058597 @default.
• W4311518761 cites W4235837913 @default.
• W4311518761 cites W4255603865 @default.

• next