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• W4311522574 endingPage "3903" @default.
• W4311522574 startingPage "3903" @default.
• W4311522574 abstract "Fifteen years after their discovery, telocytes (TCs) are yet perceived as a new stromal cell type. Their presence was initially documented peri-digestively, and gradually throughout the interstitia of many (non-)cavitary mammalian, human, and avian organs, including skin. Each time, TCs proved to be involved in diverse spatial relations with elements of interstitial (ultra)structure (blood vessels, nerves, immune cells, etc.). To date, transmission electron microscopy (TEM) remained the single main microscopic technique able to correctly and certainly attest TCs by their well-acknowledged (ultra)structure. In skin, dermal TCs reiterate almost all (ultra)structural features ascribed to TCs in other locations, with apparent direct implications in skin physiology and/or pathology. TCs' uneven distribution within skin, mainly located in stem cell niches, suggests involvement in either skin homeostasis or dermatological pathologies. On the other hand, different skin diseases involve different patterns of disruption of TCs' structure and ultrastructure. TCs' cellular cooperation with other interstitial elements, their immunological profile, and their changes during remission of diseases suggest their role(s) in tissue regeneration/repair processes. Thus, expanding the knowledge on dermal TCs could offer new insights into the natural skin capacity of self-repairing. Moreover, it would become attractive to consider that augmenting dermal TCs' presence/density could become an attractive therapeutic alternative for treating various skin defects." @default.
• W4311522574 created "2022-12-26" @default.
• W4311522574 creator A5009472864 @default.
• W4311522574 creator A5057251848 @default.
• W4311522574 creator A5071266152 @default.
• W4311522574 creator A5085771528 @default.
• W4311522574 date "2022-12-02" @default.
• W4311522574 modified "2023-10-14" @default.
• W4311522574 title "Dermal Telocytes: A Different Viewpoint of Skin Repairing and Regeneration" @default.
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