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• W4311525024 abstract "The aim is to provide an overview of recent research on genetic factors that influence preterm birth in the context of neonatal phenotypic assessment.This is a nonsystematic review of the recent scientific literature.Maternal and fetal genetic diversity and rare genome variants are linked with crucial immune response sites. In addition, more frequent in preterm neonates, de novo variants may lead to attention deficits, hyperactivity, autism spectrum disorders, and infertility of both sexes later in life. Environmental factors may also greatly burden fetal, and consequently, neonatal development and neurodevelopment through a failure in the fetal epigenome reprogramming process and even influence the initiation of spontaneous preterm pregnancy termination. Minimally invasive analysis of the transcription factors associated with preterm birth helps elucidate labor mechanisms and predict its timing. We also provide valuable summaries of genomic and transcriptomic factors that contribute to preterm birth.Investigation of the human genome, epigenome, and transcriptome helps to identify molecular mechanisms linked with preterm delivery and premature newborn clinical appearance in early and late neonatal life and even predict developmental outcomes. Further studies are needed to fully understand the implications of genetic changes in preterm births. These data could be used to develop targeted interventions aimed at selecting the most effective individual treatment and rehabilitation plan." @default.
• W4311525024 created "2022-12-26" @default.
• W4311525024 creator A5013140773 @default.
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• W4311525024 creator A5061498549 @default.
• W4311525024 creator A5069151565 @default.
• W4311525024 date "2022-12-15" @default.
• W4311525024 modified "2023-10-14" @default.
• W4311525024 title "Causes of preterm birth: Genetic factors in preterm birth and preterm infant phenotypes" @default.
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