FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311534027> ?p ?o ?g. }

• W4311534027 endingPage "1042" @default.
• W4311534027 startingPage "1035" @default.
• W4311534027 abstract "Abstract Aims Heart failure with mildly reduced ejection fraction (HFmrEF) has received increasing attention following the publication of the latest ESC guidelines in 2021. However, it remains unclear whether patients with HFmrEF could benefit from guideline‐directed medical treatment (GDMT), referring the combination of ACEI/ARB/ARNI, β‐blockers, and MRAs, which are recommended for those with reduced ejection fraction. This study explored the efficacy of GDMT in HFmrEF patients. Methods This was a retrospective cohort study of HFmrEF patients admitted to The First Affiliated Hospital of Dalian Medical University between 1 September 2015 and 30 November 2019. Propensity score matching (1:2) between patients receiving triple‐drug therapy (TT) and non‐triple therapy (NTT) based on age and sex was performed. The primary outcome was all cause death, cardiac death, rehospitalization from any cause, and rehospitalization due to worsening heart failure. Results Of the 906 patients enrolled in the matched cohort (TT group, n = 302; NTT group, N = 604), 653 (72.08%) were male, and mean age was 61.1 ± 11.92. Survival analysis suggested that TT group experienced a significantly lower incidence of prespecified primary endpoints than NTT group. Multivariable Cox regression showed that TT group had a lower risk of all‐cause mortality (HR 0.656, 95% CI 0.447–0.961, P = 0.030), cardiac death (HR 0.599, 95% CI 0.380–0.946, P = 0.028), any‐cause rehospitalization (HR 0.687, 95% CI 0.541–0.872, P = 0.002), and heart failure rehospitalization (HR 0.732, 95% CI 0.565–0.948, P = 0.018). Conclusions In patients with HFmrEF, combined use of neurohormonal antagonists produces remarkable effects in reducing the occurrence of the primary outcome of rehospitalization and death. Thus, the treatment of HFmrEF should be categorized as HFrEF due to the similar benefit of neurohormonal blocking therapy in HFrEF and HFmrEF." @default.
• W4311534027 created "2022-12-26" @default.
• W4311534027 creator A5012148234 @default.
• W4311534027 creator A5034877940 @default.
• W4311534027 creator A5035441171 @default.
• W4311534027 creator A5043839950 @default.
• W4311534027 creator A5057377195 @default.
• W4311534027 creator A5058435157 @default.
• W4311534027 creator A5060002817 @default.
• W4311534027 creator A5071236458 @default.
• W4311534027 creator A5072453373 @default.
• W4311534027 creator A5075405738 @default.
• W4311534027 creator A5091391476 @default.
• W4311534027 date "2022-12-15" @default.
• W4311534027 modified "2023-10-14" @default.
• W4311534027 title "Efficacy of guideline‐directed medical treatment in heart failure with mildly reduced ejection fraction" @default.
• W4311534027 cites W124066534 @default.
• W4311534027 cites W2113698123 @default.
• W4311534027 cites W2152072062 @default.
• W4311534027 cites W2159700625 @default.
• W4311534027 cites W2172025889 @default.
• W4311534027 cites W2187526770 @default.
• W4311534027 cites W2217213299 @default.
• W4311534027 cites W2281894904 @default.
• W4311534027 cites W2563428721 @default.
• W4311534027 cites W2600206260 @default.
• W4311534027 cites W2750637474 @default.
• W4311534027 cites W2758197294 @default.
• W4311534027 cites W2761111693 @default.
• W4311534027 cites W2791312658 @default.
• W4311534027 cites W2890860135 @default.
• W4311534027 cites W2913008332 @default.
• W4311534027 cites W2947100277 @default.
• W4311534027 cites W2954639488 @default.
• W4311534027 cites W2971294569 @default.
• W4311534027 cites W2972966208 @default.
• W4311534027 cites W3005051749 @default.
• W4311534027 cites W3045021447 @default.
• W4311534027 cites W3093638804 @default.
• W4311534027 cites W3120815680 @default.
• W4311534027 cites W3123881254 @default.
• W4311534027 cites W3190249853 @default.
• W4311534027 cites W3193598686 @default.
• W4311534027 cites W3204801135 @default.
• W4311534027 cites W3209925566 @default.
• W4311534027 cites W4311534027 @default.
• W4311534027 doi "https://doi.org/10.1002/ehf2.14199" @default.
• W4311534027 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36519802" @default.
• W4311534027 hasPublicationYear "2022" @default.
• W4311534027 type Work @default.
• W4311534027 citedByCount "2" @default.
• W4311534027 countsByYear W43115340272022 @default.
• W4311534027 crossrefType "journal-article" @default.
• W4311534027 hasAuthorship W4311534027A5012148234 @default.
• W4311534027 hasAuthorship W4311534027A5034877940 @default.
• W4311534027 hasAuthorship W4311534027A5035441171 @default.
• W4311534027 hasAuthorship W4311534027A5043839950 @default.
• W4311534027 hasAuthorship W4311534027A5057377195 @default.
• W4311534027 hasAuthorship W4311534027A5058435157 @default.
• W4311534027 hasAuthorship W4311534027A5060002817 @default.
• W4311534027 hasAuthorship W4311534027A5071236458 @default.
• W4311534027 hasAuthorship W4311534027A5072453373 @default.
• W4311534027 hasAuthorship W4311534027A5075405738 @default.
• W4311534027 hasAuthorship W4311534027A5091391476 @default.
• W4311534027 hasBestOaLocation W43115340271 @default.
• W4311534027 hasConcept C120665830 @default.
• W4311534027 hasConcept C121332964 @default.
• W4311534027 hasConcept C126322002 @default.
• W4311534027 hasConcept C142724271 @default.
• W4311534027 hasConcept C164705383 @default.
• W4311534027 hasConcept C167135981 @default.
• W4311534027 hasConcept C17923572 @default.
• W4311534027 hasConcept C2778198053 @default.
• W4311534027 hasConcept C2780182762 @default.
• W4311534027 hasConcept C50382708 @default.
• W4311534027 hasConcept C61511704 @default.
• W4311534027 hasConcept C71924100 @default.
• W4311534027 hasConcept C72563966 @default.
• W4311534027 hasConcept C78085059 @default.
• W4311534027 hasConceptScore W4311534027C120665830 @default.
• W4311534027 hasConceptScore W4311534027C121332964 @default.
• W4311534027 hasConceptScore W4311534027C126322002 @default.
• W4311534027 hasConceptScore W4311534027C142724271 @default.
• W4311534027 hasConceptScore W4311534027C164705383 @default.
• W4311534027 hasConceptScore W4311534027C167135981 @default.
• W4311534027 hasConceptScore W4311534027C17923572 @default.
• W4311534027 hasConceptScore W4311534027C2778198053 @default.
• W4311534027 hasConceptScore W4311534027C2780182762 @default.
• W4311534027 hasConceptScore W4311534027C50382708 @default.
• W4311534027 hasConceptScore W4311534027C61511704 @default.
• W4311534027 hasConceptScore W4311534027C71924100 @default.
• W4311534027 hasConceptScore W4311534027C72563966 @default.
• W4311534027 hasConceptScore W4311534027C78085059 @default.
• W4311534027 hasFunder F4320321001 @default.
• W4311534027 hasIssue "2" @default.
• W4311534027 hasLocation W43115340271 @default.
• W4311534027 hasLocation W43115340272 @default.
• W4311534027 hasLocation W43115340273 @default.

• next