Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311542931> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4311542931 endingPage "506" @default.
- W4311542931 startingPage "506" @default.
- W4311542931 abstract "Introduction: Rapid administration of four-factor prothrombin complex concentrate (4F-PCC) for the reversal of bleeding in patients on oral anticoagulation presenting to the emergency department (ED) is crucial as it reduces hematoma expansion and decreases length of stay. Emerging data lists reduced administration time while maintaining similar outcomes as major benefits of fixed-dose vs weight-based dosing strategies. The purpose of this study is to determine if pharmacist presence in the ED decreases time to administration of 4F-PCC after implementing a fixed-dose strategy. Methods: A single-center retrospective chart review was conducted for patients who received 4F-PCC during ED admission from January 1, 2016 to July 31, 2022. Patients were excluded if they were less than 18 years of age. Patient demographics, time to administration, pharmacist presence, and concordance with institutional protocol were collected. The primary outcome was time from 4F-PCC order placement to administration in the pharmacist present fixed-dose regimen cohort. Secondary outcomes included overall time to administration in the weight-based vs fixed-dose cohorts and 4F-PCC concordance with protocol. Results: Of the 129 patients evaluated, 93 (72.1%) patients received weight-based and 36 (27.9%) patients received fixed-dose 4F-PCC. A pharmacist was present in 48 (51.6%) weight-based cases and 23 (63.9%) fixed-dose cases. Most patients presented with intracranial hemorrhage (73.6%) and on apixaban (40.3%). There was a significant reduction in administration time in the pharmacist present fixed-dose 4F-PCC cohort (21 vs 65 min, p< 0.00001). With pharmacist absence, there was a significant reduction in administration time for fixed-dose vs weight-based 4F-PCC (25 vs 46 min, p=0.002). Pharmacist presence did not result in a significant reduction in discordant 4F-PCC use in the overall population (p=0.0783). Conclusions: Previous studies demonstrated the positive impact of pharmacists on patients regarding reduction of 4F-PCC administration time. This study demonstrated that pharmacists further reduced 4F-PCC administration time by 44 minutes even with a simplified dosing strategy. This study did not demonstrate pharmacist reduction in discordant 4F-PCC use likely due to the highly protocolized nature of this medication." @default.
- W4311542931 created "2022-12-27" @default.
- W4311542931 creator A5055204664 @default.
- W4311542931 creator A5078188008 @default.
- W4311542931 creator A5079484472 @default.
- W4311542931 creator A5087152552 @default.
- W4311542931 date "2022-12-15" @default.
- W4311542931 modified "2023-09-30" @default.
- W4311542931 title "1024: PHARMACISTS DECREASE TIME TO PROTHROMBIN COMPLEX CONCENTRATE REGARDLESS OF DOSING STRATEGY" @default.
- W4311542931 doi "https://doi.org/10.1097/01.ccm.0000909824.71107.11" @default.
- W4311542931 hasPublicationYear "2022" @default.
- W4311542931 type Work @default.
- W4311542931 citedByCount "0" @default.
- W4311542931 crossrefType "journal-article" @default.
- W4311542931 hasAuthorship W4311542931A5055204664 @default.
- W4311542931 hasAuthorship W4311542931A5078188008 @default.
- W4311542931 hasAuthorship W4311542931A5079484472 @default.
- W4311542931 hasAuthorship W4311542931A5087152552 @default.
- W4311542931 hasBestOaLocation W43115429311 @default.
- W4311542931 hasConcept C104863432 @default.
- W4311542931 hasConcept C118552586 @default.
- W4311542931 hasConcept C126322002 @default.
- W4311542931 hasConcept C160798450 @default.
- W4311542931 hasConcept C167135981 @default.
- W4311542931 hasConcept C187212893 @default.
- W4311542931 hasConcept C194828623 @default.
- W4311542931 hasConcept C2776301958 @default.
- W4311542931 hasConcept C2777091921 @default.
- W4311542931 hasConcept C2777288759 @default.
- W4311542931 hasConcept C2779161974 @default.
- W4311542931 hasConcept C2779457091 @default.
- W4311542931 hasConcept C2780724011 @default.
- W4311542931 hasConcept C2781413609 @default.
- W4311542931 hasConcept C42219234 @default.
- W4311542931 hasConcept C512399662 @default.
- W4311542931 hasConcept C71924100 @default.
- W4311542931 hasConcept C72563966 @default.
- W4311542931 hasConceptScore W4311542931C104863432 @default.
- W4311542931 hasConceptScore W4311542931C118552586 @default.
- W4311542931 hasConceptScore W4311542931C126322002 @default.
- W4311542931 hasConceptScore W4311542931C160798450 @default.
- W4311542931 hasConceptScore W4311542931C167135981 @default.
- W4311542931 hasConceptScore W4311542931C187212893 @default.
- W4311542931 hasConceptScore W4311542931C194828623 @default.
- W4311542931 hasConceptScore W4311542931C2776301958 @default.
- W4311542931 hasConceptScore W4311542931C2777091921 @default.
- W4311542931 hasConceptScore W4311542931C2777288759 @default.
- W4311542931 hasConceptScore W4311542931C2779161974 @default.
- W4311542931 hasConceptScore W4311542931C2779457091 @default.
- W4311542931 hasConceptScore W4311542931C2780724011 @default.
- W4311542931 hasConceptScore W4311542931C2781413609 @default.
- W4311542931 hasConceptScore W4311542931C42219234 @default.
- W4311542931 hasConceptScore W4311542931C512399662 @default.
- W4311542931 hasConceptScore W4311542931C71924100 @default.
- W4311542931 hasConceptScore W4311542931C72563966 @default.
- W4311542931 hasIssue "1" @default.
- W4311542931 hasLocation W43115429311 @default.
- W4311542931 hasLocation W43115429312 @default.
- W4311542931 hasOpenAccess W4311542931 @default.
- W4311542931 hasPrimaryLocation W43115429311 @default.
- W4311542931 hasRelatedWork W104778587 @default.
- W4311542931 hasRelatedWork W1994841726 @default.
- W4311542931 hasRelatedWork W233263293 @default.
- W4311542931 hasRelatedWork W2529366806 @default.
- W4311542931 hasRelatedWork W2553240552 @default.
- W4311542931 hasRelatedWork W2647702635 @default.
- W4311542931 hasRelatedWork W2754584895 @default.
- W4311542931 hasRelatedWork W2889169526 @default.
- W4311542931 hasRelatedWork W2994930828 @default.
- W4311542931 hasRelatedWork W4297523986 @default.
- W4311542931 hasVolume "51" @default.
- W4311542931 isParatext "false" @default.
- W4311542931 isRetracted "false" @default.
- W4311542931 workType "article" @default.