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• W4311543574 endingPage "113096" @default.
• W4311543574 startingPage "113096" @default.
• W4311543574 abstract "Recently, the healing of chronic wounds such as extensive burns has become a serious and intractable clinical problem. Avoiding wound infection and retaining an appropriate level of moisture around wounds are significant challenges in wound care. Herein, a dual-network hydrogel composed of sodium alginate (SA) and platelet-rich plasma (PRP) was designed to facilitate the wound healing. The preparation of hydrogel was achieved through a simple one-step thrombin activation process. The morphological characterization results revealed the three-dimensional network structure of the hydrogel. Then, certain levels of epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) were detected in phosphate buffer solution (PBS) cultured hydrogel, which led to the possibility of cell proliferation and vascular regeneration. When topically applied to the wound skin of rats, the hydrogel presented high wound closure effectiveness. In conclusion, this strategy provides a simple and feasible approach to overcoming the shortcomings of conventional wound dressings." @default.
• W4311543574 created "2022-12-27" @default.
• W4311543574 creator A5028053683 @default.
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• W4311543574 date "2023-02-01" @default.
• W4311543574 modified "2023-10-16" @default.
• W4311543574 title "Sodium alginate hydrogel containing platelet-rich plasma for wound healing" @default.
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• W4311543574 doi "https://doi.org/10.1016/j.colsurfb.2022.113096" @default.
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