Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311551454> ?p ?o ?g. }
- W4311551454 abstract "Chimeric antigen receptor (CAR) T cells are ineffective against solid tumors with immunosuppressive microenvironments. To overcome suppression, we engineered circuits in which tumor-specific synNotch receptors locally induce production of the cytokine IL-2. These circuits potently enhance CAR T cell infiltration and clearance of immune-excluded tumors, without systemic toxicity. The most effective IL-2 induction circuit acts in an autocrine and T cell receptor (TCR)- or CAR-independent manner, bypassing suppression mechanisms including consumption of IL-2 or inhibition of TCR signaling. These engineered cells establish a foothold in the target tumors, with synthetic Notch-induced IL-2 production enabling initiation of CAR-mediated T cell expansion and cell killing. Thus, it is possible to reconstitute synthetic T cell circuits that activate the outputs ultimately required for an antitumor response, but in a manner that evades key points of tumor suppression." @default.
- W4311551454 created "2022-12-27" @default.
- W4311551454 creator A5003015731 @default.
- W4311551454 creator A5005613277 @default.
- W4311551454 creator A5006257775 @default.
- W4311551454 creator A5006385718 @default.
- W4311551454 creator A5009173792 @default.
- W4311551454 creator A5009958453 @default.
- W4311551454 creator A5017689503 @default.
- W4311551454 creator A5018654168 @default.
- W4311551454 creator A5049157751 @default.
- W4311551454 creator A5055951401 @default.
- W4311551454 creator A5074263773 @default.
- W4311551454 creator A5075005838 @default.
- W4311551454 creator A5076364132 @default.
- W4311551454 creator A5080690656 @default.
- W4311551454 creator A5082065492 @default.
- W4311551454 creator A5091876535 @default.
- W4311551454 date "2022-12-16" @default.
- W4311551454 modified "2023-10-16" @default.
- W4311551454 title "Synthetic cytokine circuits that drive T cells into immune-excluded tumors" @default.
- W4311551454 cites W1524005671 @default.
- W4311551454 cites W1541816872 @default.
- W4311551454 cites W1576457524 @default.
- W4311551454 cites W1631320694 @default.
- W4311551454 cites W1635590414 @default.
- W4311551454 cites W1859254390 @default.
- W4311551454 cites W1950572133 @default.
- W4311551454 cites W1974351164 @default.
- W4311551454 cites W1980484335 @default.
- W4311551454 cites W1985126564 @default.
- W4311551454 cites W1987589866 @default.
- W4311551454 cites W1990555844 @default.
- W4311551454 cites W1992995822 @default.
- W4311551454 cites W1993051112 @default.
- W4311551454 cites W1997403488 @default.
- W4311551454 cites W2000869878 @default.
- W4311551454 cites W2002132740 @default.
- W4311551454 cites W2019182972 @default.
- W4311551454 cites W2025887649 @default.
- W4311551454 cites W2053330214 @default.
- W4311551454 cites W2081600566 @default.
- W4311551454 cites W2116089582 @default.
- W4311551454 cites W2116943123 @default.
- W4311551454 cites W2116967305 @default.
- W4311551454 cites W2120813964 @default.
- W4311551454 cites W2148252058 @default.
- W4311551454 cites W2155906863 @default.
- W4311551454 cites W2162937174 @default.
- W4311551454 cites W2165119413 @default.
- W4311551454 cites W2256857837 @default.
- W4311551454 cites W2258336271 @default.
- W4311551454 cites W2344037260 @default.
- W4311551454 cites W2514649790 @default.
- W4311551454 cites W2556133499 @default.
- W4311551454 cites W2563021476 @default.
- W4311551454 cites W2591978212 @default.
- W4311551454 cites W2604869968 @default.
- W4311551454 cites W2785803176 @default.
- W4311551454 cites W2810919053 @default.
- W4311551454 cites W2836754285 @default.
- W4311551454 cites W2900813143 @default.
- W4311551454 cites W2903062212 @default.
- W4311551454 cites W2961584252 @default.
- W4311551454 cites W2965330503 @default.
- W4311551454 cites W2971050087 @default.
- W4311551454 cites W3026266297 @default.
- W4311551454 cites W3109929953 @default.
- W4311551454 cites W3119561596 @default.
- W4311551454 cites W3121841314 @default.
- W4311551454 cites W3133229959 @default.
- W4311551454 cites W3173668760 @default.
- W4311551454 cites W3184584468 @default.
- W4311551454 cites W4200593773 @default.
- W4311551454 doi "https://doi.org/10.1126/science.aba1624" @default.
- W4311551454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36520915" @default.
- W4311551454 hasPublicationYear "2022" @default.
- W4311551454 type Work @default.
- W4311551454 citedByCount "32" @default.
- W4311551454 countsByYear W43115514542022 @default.
- W4311551454 countsByYear W43115514542023 @default.
- W4311551454 crossrefType "journal-article" @default.
- W4311551454 hasAuthorship W4311551454A5003015731 @default.
- W4311551454 hasAuthorship W4311551454A5005613277 @default.
- W4311551454 hasAuthorship W4311551454A5006257775 @default.
- W4311551454 hasAuthorship W4311551454A5006385718 @default.
- W4311551454 hasAuthorship W4311551454A5009173792 @default.
- W4311551454 hasAuthorship W4311551454A5009958453 @default.
- W4311551454 hasAuthorship W4311551454A5017689503 @default.
- W4311551454 hasAuthorship W4311551454A5018654168 @default.
- W4311551454 hasAuthorship W4311551454A5049157751 @default.
- W4311551454 hasAuthorship W4311551454A5055951401 @default.
- W4311551454 hasAuthorship W4311551454A5074263773 @default.
- W4311551454 hasAuthorship W4311551454A5075005838 @default.
- W4311551454 hasAuthorship W4311551454A5076364132 @default.
- W4311551454 hasAuthorship W4311551454A5080690656 @default.
- W4311551454 hasAuthorship W4311551454A5082065492 @default.
- W4311551454 hasAuthorship W4311551454A5091876535 @default.
- W4311551454 hasBestOaLocation W43115514542 @default.
- W4311551454 hasConcept C128240485 @default.