Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311551459> ?p ?o ?g. }
- W4311551459 endingPage "1234" @default.
- W4311551459 startingPage "1227" @default.
- W4311551459 abstract "Synthetic gene circuits that precisely control human cell function could expand the capabilities of gene- and cell-based therapies. However, platforms for developing circuits in primary human cells that drive robust functional changes in vivo and have compositions suitable for clinical use are lacking. Here, we developed synthetic zinc finger transcription regulators (synZiFTRs), which are compact and based largely on human-derived proteins. As a proof of principle, we engineered gene switches and circuits that allow precise, user-defined control over therapeutically relevant genes in primary T cells using orthogonal, US Food and Drug Administration-approved small-molecule inducers. Our circuits can instruct T cells to sequentially activate multiple cellular programs such as proliferation and antitumor activity to drive synergistic therapeutic responses. This platform should accelerate the development and clinical translation of synthetic gene circuits in diverse human cell types and contexts." @default.
- W4311551459 created "2022-12-27" @default.
- W4311551459 creator A5005840545 @default.
- W4311551459 creator A5015981980 @default.
- W4311551459 creator A5023904642 @default.
- W4311551459 creator A5056371639 @default.
- W4311551459 creator A5056388947 @default.
- W4311551459 creator A5058473669 @default.
- W4311551459 creator A5063384029 @default.
- W4311551459 creator A5070658947 @default.
- W4311551459 creator A5074263773 @default.
- W4311551459 creator A5077288103 @default.
- W4311551459 date "2022-12-16" @default.
- W4311551459 modified "2023-10-16" @default.
- W4311551459 title "Multidimensional control of therapeutic human cell function with synthetic gene circuits" @default.
- W4311551459 cites W1517571912 @default.
- W4311551459 cites W1609710757 @default.
- W4311551459 cites W1621802947 @default.
- W4311551459 cites W1970669095 @default.
- W4311551459 cites W1973980688 @default.
- W4311551459 cites W1990906839 @default.
- W4311551459 cites W2003665511 @default.
- W4311551459 cites W2032015331 @default.
- W4311551459 cites W2035420256 @default.
- W4311551459 cites W2041537542 @default.
- W4311551459 cites W2044741494 @default.
- W4311551459 cites W2052997401 @default.
- W4311551459 cites W2053330214 @default.
- W4311551459 cites W2054677438 @default.
- W4311551459 cites W2056406543 @default.
- W4311551459 cites W2059528690 @default.
- W4311551459 cites W2061650108 @default.
- W4311551459 cites W2066218351 @default.
- W4311551459 cites W2070614858 @default.
- W4311551459 cites W2085819365 @default.
- W4311551459 cites W2090429649 @default.
- W4311551459 cites W2094945699 @default.
- W4311551459 cites W2101749257 @default.
- W4311551459 cites W2116089582 @default.
- W4311551459 cites W2124985265 @default.
- W4311551459 cites W2128016314 @default.
- W4311551459 cites W2128328355 @default.
- W4311551459 cites W2130069008 @default.
- W4311551459 cites W2132256310 @default.
- W4311551459 cites W2132291850 @default.
- W4311551459 cites W2133897272 @default.
- W4311551459 cites W2150329966 @default.
- W4311551459 cites W2158243563 @default.
- W4311551459 cites W2159844490 @default.
- W4311551459 cites W2167523976 @default.
- W4311551459 cites W2170551349 @default.
- W4311551459 cites W2179438025 @default.
- W4311551459 cites W2221404162 @default.
- W4311551459 cites W2257306932 @default.
- W4311551459 cites W2258336271 @default.
- W4311551459 cites W2285036080 @default.
- W4311551459 cites W2317579024 @default.
- W4311551459 cites W2526887159 @default.
- W4311551459 cites W2559919850 @default.
- W4311551459 cites W2587691649 @default.
- W4311551459 cites W2759643796 @default.
- W4311551459 cites W2772195672 @default.
- W4311551459 cites W2785792383 @default.
- W4311551459 cites W2786631874 @default.
- W4311551459 cites W2800187318 @default.
- W4311551459 cites W2806001790 @default.
- W4311551459 cites W2809376056 @default.
- W4311551459 cites W2811327039 @default.
- W4311551459 cites W2851261758 @default.
- W4311551459 cites W2897403793 @default.
- W4311551459 cites W2900314314 @default.
- W4311551459 cites W2902825844 @default.
- W4311551459 cites W2904947448 @default.
- W4311551459 cites W2924629992 @default.
- W4311551459 cites W2937836868 @default.
- W4311551459 cites W2948879734 @default.
- W4311551459 cites W2949380898 @default.
- W4311551459 cites W2963298310 @default.
- W4311551459 cites W2963418941 @default.
- W4311551459 cites W2995900562 @default.
- W4311551459 cites W3005214927 @default.
- W4311551459 cites W3005412445 @default.
- W4311551459 cites W3010959258 @default.
- W4311551459 cites W3042599313 @default.
- W4311551459 cites W3046624515 @default.
- W4311551459 cites W3093992907 @default.
- W4311551459 cites W3150736119 @default.
- W4311551459 cites W3157520262 @default.
- W4311551459 cites W3159888487 @default.
- W4311551459 cites W3198740632 @default.
- W4311551459 cites W4224056900 @default.
- W4311551459 cites W4232131065 @default.
- W4311551459 cites W4246341361 @default.
- W4311551459 cites W4249558460 @default.
- W4311551459 cites W4253785452 @default.
- W4311551459 cites W4281666488 @default.
- W4311551459 doi "https://doi.org/10.1126/science.ade0156" @default.
- W4311551459 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36520914" @default.