Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311552016> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W4311552016 abstract "Abstract Background Nudging with purposeful, directed comments to microbiology results appears to improve antibiotic prescribing. The study objective was to assess prescribing before and after a β-lactamase interpretative comment for Haemophilus influenzae and Moraxella catarrhalis lower respiratory tract infections (LRTI). Methods IRB approved, quasi-experiment. Included: hospitalized adults prescribed antibiotics for H. influenzae or M. catarrhalis LRTI from 8/20/17-3/19/19 (pre-group) and 3/20/19-8/20/21 (post-group). Excluded: non-LRTI, polymicrobial infections, antibiotic prophylaxis, IgE-mediated β-lactam allergy. Intervention- automated comment for β-lactamase negative: “this organism is predictably susceptible to ampicillin or amoxicillin”; β-lactamase positive: “this organism is predictably susceptible to ampicillin-sulbactam or amoxicillin-clavulanate”. Primary endpoint: optimal de-escalation, defined as ampicillin, amoxicillin or aminopenicillins for β-lactamase negative; amoxicillin/clavulanate or ampicillin/sulbactam for β-lactamase positive. Secondary endpoints: clinical success, antibiotic duration, time to de-escalation. Sample size: 200 calculated for 30% difference in de-escalation, α=0.05, β=0.2. Results Enrolled 100 pre- and 101 post. 61% vs. 64% male; 63% vs. 73% community-acquired pneumonia; 20% vs. 15% hospital acquired pneumonia; 17% vs. 12% ventilator associated pneumonia; 81% vs. 77% H. influenzae; 46% vs. 52% β-lactamase positive; 4% vs. 7% non-IgE β-lactam allergy, respectively. Optimal de-escalation: 19 (19%) pre-, 51 (51%) post- (p< 0.001). After adjustment, post-group associated with 5-fold increased odds of optimal de-escalation (Table 1). Secondary endpoints pre and post: median (IQR) duration 7 (6, 8) and 7 days (6, 10); median time to de-escalation: 1 (0, 2) and 0 (0, 1) days; clinical success: 79 (79%) and 81 (80%). Conclusion An automated, β-lactamase nudge was associated with a reduction in definitive broad-spectrum antibiotics. Stewardship programs should continue to evaluate persuasive comments as an effective and efficient intervention. Disclosures All Authors: No reported disclosures." @default.
- W4311552016 created "2022-12-27" @default.
- W4311552016 creator A5009039786 @default.
- W4311552016 creator A5021111881 @default.
- W4311552016 creator A5030981999 @default.
- W4311552016 creator A5084321618 @default.
- W4311552016 creator A5089968711 @default.
- W4311552016 date "2022-12-01" @default.
- W4311552016 modified "2023-09-30" @default.
- W4311552016 title "889. Another Respiratory Culture Nudge Improves Pneumonia Prescribing" @default.
- W4311552016 doi "https://doi.org/10.1093/ofid/ofac492.734" @default.
- W4311552016 hasPublicationYear "2022" @default.
- W4311552016 type Work @default.
- W4311552016 citedByCount "0" @default.
- W4311552016 crossrefType "journal-article" @default.
- W4311552016 hasAuthorship W4311552016A5009039786 @default.
- W4311552016 hasAuthorship W4311552016A5021111881 @default.
- W4311552016 hasAuthorship W4311552016A5030981999 @default.
- W4311552016 hasAuthorship W4311552016A5084321618 @default.
- W4311552016 hasAuthorship W4311552016A5089968711 @default.
- W4311552016 hasBestOaLocation W43115520161 @default.
- W4311552016 hasConcept C126322002 @default.
- W4311552016 hasConcept C2776012195 @default.
- W4311552016 hasConcept C2776021129 @default.
- W4311552016 hasConcept C2776399701 @default.
- W4311552016 hasConcept C2776551000 @default.
- W4311552016 hasConcept C2776925733 @default.
- W4311552016 hasConcept C2777184939 @default.
- W4311552016 hasConcept C2777914695 @default.
- W4311552016 hasConcept C2778478555 @default.
- W4311552016 hasConcept C2779454058 @default.
- W4311552016 hasConcept C2779631663 @default.
- W4311552016 hasConcept C2779708577 @default.
- W4311552016 hasConcept C501593827 @default.
- W4311552016 hasConcept C534529494 @default.
- W4311552016 hasConcept C71924100 @default.
- W4311552016 hasConcept C86803240 @default.
- W4311552016 hasConcept C89423630 @default.
- W4311552016 hasConcept C94665300 @default.
- W4311552016 hasConceptScore W4311552016C126322002 @default.
- W4311552016 hasConceptScore W4311552016C2776012195 @default.
- W4311552016 hasConceptScore W4311552016C2776021129 @default.
- W4311552016 hasConceptScore W4311552016C2776399701 @default.
- W4311552016 hasConceptScore W4311552016C2776551000 @default.
- W4311552016 hasConceptScore W4311552016C2776925733 @default.
- W4311552016 hasConceptScore W4311552016C2777184939 @default.
- W4311552016 hasConceptScore W4311552016C2777914695 @default.
- W4311552016 hasConceptScore W4311552016C2778478555 @default.
- W4311552016 hasConceptScore W4311552016C2779454058 @default.
- W4311552016 hasConceptScore W4311552016C2779631663 @default.
- W4311552016 hasConceptScore W4311552016C2779708577 @default.
- W4311552016 hasConceptScore W4311552016C501593827 @default.
- W4311552016 hasConceptScore W4311552016C534529494 @default.
- W4311552016 hasConceptScore W4311552016C71924100 @default.
- W4311552016 hasConceptScore W4311552016C86803240 @default.
- W4311552016 hasConceptScore W4311552016C89423630 @default.
- W4311552016 hasConceptScore W4311552016C94665300 @default.
- W4311552016 hasIssue "Supplement_2" @default.
- W4311552016 hasLocation W43115520161 @default.
- W4311552016 hasOpenAccess W4311552016 @default.
- W4311552016 hasPrimaryLocation W43115520161 @default.
- W4311552016 hasRelatedWork W2017752285 @default.
- W4311552016 hasRelatedWork W2027728536 @default.
- W4311552016 hasRelatedWork W2167553066 @default.
- W4311552016 hasRelatedWork W2391591253 @default.
- W4311552016 hasRelatedWork W2398571257 @default.
- W4311552016 hasRelatedWork W2406395351 @default.
- W4311552016 hasRelatedWork W2409699908 @default.
- W4311552016 hasRelatedWork W2416300773 @default.
- W4311552016 hasRelatedWork W3084423626 @default.
- W4311552016 hasRelatedWork W4311552016 @default.
- W4311552016 hasVolume "9" @default.
- W4311552016 isParatext "false" @default.
- W4311552016 isRetracted "false" @default.
- W4311552016 workType "article" @default.