FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311556634> ?p ?o ?g. }

• W4311556634 endingPage "e1010516" @default.
• W4311556634 startingPage "e1010516" @default.
• W4311556634 abstract "Regeneration relies on cell proliferation to restore damaged tissues. Multiple signaling pathways activated by local or paracrine cues have been identified to promote regenerative proliferation. How different types of tissue damage may activate distinct signaling pathways and how these differences converge on regenerative proliferation is less well defined. To better understand how tissue damage and proliferative signals are integrated during regeneration, we investigate models of compensatory proliferation in Drosophila imaginal discs. We find that compensatory proliferation is associated with a unique cell cycle profile, which is characterized by short G1 and G2 phases and, surprisingly, by acceleration of the S-phase. S-phase acceleration can be induced by two distinct signaling signatures, aligning with inflammatory and non-inflammatory tissue damage. Specifically, non-autonomous activation of JAK/STAT and Myc in response to inflammatory damage, or local activation of Ras/ERK and Hippo/Yki in response to elevated cell death, promote accelerated nucleotide incorporation during S-phase. This previously unappreciated convergence of different damaging insults on the same regenerative cell cycle program reconciles previous conflicting observations on proliferative signaling in different tissue regeneration and tumor models." @default.
• W4311556634 created "2022-12-27" @default.
• W4311556634 creator A5007498609 @default.
• W4311556634 creator A5013538201 @default.
• W4311556634 creator A5020100572 @default.
• W4311556634 creator A5042687430 @default.
• W4311556634 creator A5042836562 @default.
• W4311556634 creator A5074555527 @default.
• W4311556634 creator A5075492275 @default.
• W4311556634 date "2022-12-15" @default.
• W4311556634 modified "2023-09-25" @default.
• W4311556634 title "Distinct signaling signatures drive compensatory proliferation via S-phase acceleration" @default.
• W4311556634 cites W1246174232 @default.
• W4311556634 cites W1607040929 @default.
• W4311556634 cites W1608217646 @default.
• W4311556634 cites W178804440 @default.
• W4311556634 cites W1831236042 @default.
• W4311556634 cites W1966435085 @default.
• W4311556634 cites W1967274310 @default.
• W4311556634 cites W1967440011 @default.
• W4311556634 cites W1973394316 @default.
• W4311556634 cites W1987465149 @default.
• W4311556634 cites W1989461823 @default.
• W4311556634 cites W2001202251 @default.
• W4311556634 cites W2011990150 @default.
• W4311556634 cites W2015907164 @default.
• W4311556634 cites W2021764678 @default.
• W4311556634 cites W2022784838 @default.
• W4311556634 cites W2024454536 @default.
• W4311556634 cites W2027142212 @default.
• W4311556634 cites W2040377035 @default.
• W4311556634 cites W2041748744 @default.
• W4311556634 cites W2049429718 @default.
• W4311556634 cites W2051412762 @default.
• W4311556634 cites W2051917372 @default.
• W4311556634 cites W2055797028 @default.
• W4311556634 cites W2055960131 @default.
• W4311556634 cites W2062739292 @default.
• W4311556634 cites W2063580176 @default.
• W4311556634 cites W2065394786 @default.
• W4311556634 cites W2080363826 @default.
• W4311556634 cites W2083942739 @default.
• W4311556634 cites W2090095287 @default.
• W4311556634 cites W2109067263 @default.
• W4311556634 cites W2110367574 @default.
• W4311556634 cites W2118321059 @default.
• W4311556634 cites W2126194853 @default.
• W4311556634 cites W2128744588 @default.
• W4311556634 cites W2130963936 @default.
• W4311556634 cites W2137674777 @default.
• W4311556634 cites W2146156306 @default.
• W4311556634 cites W2146548337 @default.
• W4311556634 cites W2157251845 @default.
• W4311556634 cites W2161742793 @default.
• W4311556634 cites W2162362951 @default.
• W4311556634 cites W2162471107 @default.
• W4311556634 cites W2167279371 @default.
• W4311556634 cites W2179863929 @default.
• W4311556634 cites W2280301780 @default.
• W4311556634 cites W2418586304 @default.
• W4311556634 cites W2460716556 @default.
• W4311556634 cites W2493489687 @default.
• W4311556634 cites W2524697235 @default.
• W4311556634 cites W2604098124 @default.
• W4311556634 cites W2611989270 @default.
• W4311556634 cites W2618711346 @default.
• W4311556634 cites W2742113171 @default.
• W4311556634 cites W2787154579 @default.
• W4311556634 cites W2792616383 @default.
• W4311556634 cites W2810325605 @default.
• W4311556634 cites W2810748925 @default.
• W4311556634 cites W2886455231 @default.
• W4311556634 cites W2891780076 @default.
• W4311556634 cites W2896549031 @default.
• W4311556634 cites W2912756259 @default.
• W4311556634 cites W2936080613 @default.
• W4311556634 cites W2949363765 @default.
• W4311556634 cites W2949896630 @default.
• W4311556634 cites W2966798736 @default.
• W4311556634 cites W3014353803 @default.
• W4311556634 cites W3034141515 @default.
• W4311556634 cites W3042023917 @default.
• W4311556634 cites W3042637608 @default.
• W4311556634 cites W3084460819 @default.
• W4311556634 cites W3091175966 @default.
• W4311556634 cites W3102445403 @default.
• W4311556634 cites W3103368541 @default.
• W4311556634 cites W3118052379 @default.
• W4311556634 cites W3135121308 @default.
• W4311556634 cites W3161536325 @default.
• W4311556634 cites W3163622027 @default.
• W4311556634 cites W3164329887 @default.
• W4311556634 cites W3164520789 @default.
• W4311556634 cites W3184495183 @default.
• W4311556634 cites W3201357319 @default.
• W4311556634 cites W3206542031 @default.
• W4311556634 cites W3216735480 @default.
• W4311556634 cites W4285014207 @default.

• next