FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311573178> ?p ?o ?g. }

• W4311573178 abstract "A highly effective malaria vaccine remains elusive despite decades of research. Plasmodium falciparum sporozoite vaccine (PfSPZ Vaccine), a metabolically active, nonreplicating, whole parasite vaccine demonstrated safety and vaccine efficacy (VE) against endemic P. falciparum for 6 months in Malian adults receiving a five-dose regimen. Safety, immunogenicity, and VE of a three-dose regimen were assessed in adults in Balonghin, Burkina Faso in a two-component study: an open-label dose escalation trial with 32 participants followed by a double-blind, randomized, placebo-controlled trial (RCT) with 80 participants randomized to receive three doses of 2.7 × 106 PfSPZ (N = 39) or normal saline (N = 41) just before malaria season. To clear parasitemia, artesunate monotherapy was administered before first and last vaccinations. Thick blood smear microscopy was performed on samples collected during illness and every 4 weeks for 72 weeks after last vaccinations, including two 6-month malaria transmission seasons. Safety outcomes were assessed in all 80 participants who received at least one dose and VE for 79 participants who received three vaccinations. Myalgia was the only symptom that differed between groups. VE (1 - risk ratio; primary VE endpoint) was 38% at 6 months (P = 0.017) and 15% at 18 months (0.078). VE (1 - hazard ratio) was 48% and 46% at 6 and 18 months (P = 0.061 and 0.018). Two weeks after the last dose, antibodies to P. falciparum circumsporozoite protein and PfSPZ were higher in protected versus unprotected vaccinees. A three-dose regimen of PfSPZ Vaccine demonstrated safety and efficacy against malaria infection in malaria-experienced adults." @default.
• W4311573178 created "2022-12-27" @default.
• W4311573178 creator A5000295555 @default.
• W4311573178 creator A5002924766 @default.
• W4311573178 creator A5008604633 @default.
• W4311573178 creator A5012502765 @default.
• W4311573178 creator A5013139296 @default.
• W4311573178 creator A5013354780 @default.
• W4311573178 creator A5014440103 @default.
• W4311573178 creator A5018146103 @default.
• W4311573178 creator A5029379996 @default.
• W4311573178 creator A5030177021 @default.
• W4311573178 creator A5033009895 @default.
• W4311573178 creator A5033353997 @default.
• W4311573178 creator A5040243211 @default.
• W4311573178 creator A5040533373 @default.
• W4311573178 creator A5040772126 @default.
• W4311573178 creator A5050755743 @default.
• W4311573178 creator A5050760415 @default.
• W4311573178 creator A5057595465 @default.
• W4311573178 creator A5059624566 @default.
• W4311573178 creator A5061573904 @default.
• W4311573178 creator A5063730678 @default.
• W4311573178 creator A5066290105 @default.
• W4311573178 creator A5070091008 @default.
• W4311573178 creator A5071673766 @default.
• W4311573178 creator A5073651555 @default.
• W4311573178 creator A5075414717 @default.
• W4311573178 creator A5082967714 @default.
• W4311573178 creator A5090201395 @default.
• W4311573178 date "2022-12-07" @default.
• W4311573178 modified "2023-10-17" @default.
• W4311573178 title "A randomized controlled trial showing safety and efficacy of a whole sporozoite vaccine against endemic malaria" @default.
• W4311573178 cites W1532851064 @default.
• W4311573178 cites W1979427692 @default.
• W4311573178 cites W1990389546 @default.
• W4311573178 cites W2004979064 @default.
• W4311573178 cites W2006786031 @default.
• W4311573178 cites W2020800417 @default.
• W4311573178 cites W2026745968 @default.
• W4311573178 cites W2035645815 @default.
• W4311573178 cites W2066918123 @default.
• W4311573178 cites W2110568683 @default.
• W4311573178 cites W2119855808 @default.
• W4311573178 cites W2125264382 @default.
• W4311573178 cites W2138891368 @default.
• W4311573178 cites W2346928357 @default.
• W4311573178 cites W2571810950 @default.
• W4311573178 cites W2587907012 @default.
• W4311573178 cites W2588256621 @default.
• W4311573178 cites W2591439676 @default.
• W4311573178 cites W2766896603 @default.
• W4311573178 cites W2811381381 @default.
• W4311573178 cites W2936057785 @default.
• W4311573178 cites W2976425563 @default.
• W4311573178 cites W2991047882 @default.
• W4311573178 cites W2997968756 @default.
• W4311573178 cites W3027370020 @default.
• W4311573178 cites W3044993434 @default.
• W4311573178 cites W3085784977 @default.
• W4311573178 cites W3092994862 @default.
• W4311573178 cites W3102870591 @default.
• W4311573178 cites W3158165973 @default.
• W4311573178 cites W3201018583 @default.
• W4311573178 cites W3211957940 @default.
• W4311573178 cites W4210883961 @default.
• W4311573178 cites W4245773289 @default.
• W4311573178 cites W4254848468 @default.
• W4311573178 cites W4292696409 @default.
• W4311573178 doi "https://doi.org/10.1126/scitranslmed.abj3776" @default.
• W4311573178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36475905" @default.
• W4311573178 hasPublicationYear "2022" @default.
• W4311573178 type Work @default.
• W4311573178 citedByCount "11" @default.
• W4311573178 countsByYear W43115731782022 @default.
• W4311573178 countsByYear W43115731782023 @default.
• W4311573178 crossrefType "journal-article" @default.
• W4311573178 hasAuthorship W4311573178A5000295555 @default.
• W4311573178 hasAuthorship W4311573178A5002924766 @default.
• W4311573178 hasAuthorship W4311573178A5008604633 @default.
• W4311573178 hasAuthorship W4311573178A5012502765 @default.
• W4311573178 hasAuthorship W4311573178A5013139296 @default.
• W4311573178 hasAuthorship W4311573178A5013354780 @default.
• W4311573178 hasAuthorship W4311573178A5014440103 @default.
• W4311573178 hasAuthorship W4311573178A5018146103 @default.
• W4311573178 hasAuthorship W4311573178A5029379996 @default.
• W4311573178 hasAuthorship W4311573178A5030177021 @default.
• W4311573178 hasAuthorship W4311573178A5033009895 @default.
• W4311573178 hasAuthorship W4311573178A5033353997 @default.
• W4311573178 hasAuthorship W4311573178A5040243211 @default.
• W4311573178 hasAuthorship W4311573178A5040533373 @default.
• W4311573178 hasAuthorship W4311573178A5040772126 @default.
• W4311573178 hasAuthorship W4311573178A5050755743 @default.
• W4311573178 hasAuthorship W4311573178A5050760415 @default.
• W4311573178 hasAuthorship W4311573178A5057595465 @default.
• W4311573178 hasAuthorship W4311573178A5059624566 @default.
• W4311573178 hasAuthorship W4311573178A5061573904 @default.
• W4311573178 hasAuthorship W4311573178A5063730678 @default.
• W4311573178 hasAuthorship W4311573178A5066290105 @default.
• W4311573178 hasAuthorship W4311573178A5070091008 @default.

• next