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- W4311576090 abstract "MICROSATELLITE INSTABILITY IN ENDOMETRIAL CANCERS The microsatellite instability reflects genetic instability that can be sought in tumors, using two methods, immunohistochemistry and molecular biology. Currently in France, a systematic evaluation of microsatellites is recommended in any endometrial cancer from diagnosis. The interest of this evaluation is threefold: diagnostic, prognostic and therapeutic. The presence of microsatellite instability in endometrial cancer allows to detect Lynch syndrome, a hereditary cancer predisposition syndrome, in some patients. The microsatellite status is essential for establishing the molecular classification of endometrial cancers, a classification which has a well-established prognostic value, and finally it determines the eligibility for immunotherapy.INSTABILITÉ DES MICROSATELLITES DANS LES CANCERS DE L’ENDOMÈTRE L’instabilité des microsatellites est le reflet d’une instabilité génétique que l’on peut rechercher dans les tumeurs, grâce à deux techniques : l’immunohistochimie et la biologie moléculaire. Actuellement, en France, une évaluation systématique des microsatellites est recommandée dans tout cancer de l’endomètre dès le diagnostic. L’intérêt de cette évaluation est triple : diagnostique, pronostique et thérapeutique. La présence d’une instabilité des microsatellites dans un cancer de l’endomètre permet de détecter chez quelques patientes un syndrome de Lynch, syndrome héréditaire de prédisposition au cancer. Le statut microsatellitaire est indispensable à l’établissement de la classification moléculaire des cancers de l’endomètre, classification qui a une valeur pronostique bien établie, et qui permet de déterminer l’éligibilité à une immunothérapie." @default.
- W4311576090 created "2022-12-27" @default.
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- W4311576090 date "2022-09-01" @default.
- W4311576090 modified "2023-09-30" @default.
- W4311576090 title "[Epidemiology, classification and risk factors of endometrial cancer]." @default.
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- W4311576090 hasPublicationYear "2022" @default.
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