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- W4311576341 abstract "Abstract The mitochondrial calcium (Ca 2+ ) uniporter (MCU) channel is responsible for mitochondrial Ca 2+ influx. Its expression was found to be upregulated in endothelial cells (ECs) under cardiovascular disease conditions. Since the role of MCU in regulating cytosolic Ca 2+ homeostasis in ECs exposed to shear stress (SS) is unknown, we studied mitochondrial Ca 2+ dynamics (that is known to decode cytosolic Ca 2+ signaling) in sheared ECs. To understand cause-and-effect, we ectopically expressed MCU in ECs. A higher percentage of MCU-transduced ECs exhibited mitochondrial Ca 2+ transients/oscillations, and at higher frequency, under SS compared to sheared control ECs. Transients/oscillations correlated with mitochondrial reactive oxygen species (mROS) flashes and mitochondrial membrane potential (ΔΨ m ) flickers, and depended on activation of the mechanosensitive Piezo1 channel and the endothelial nitric oxide synthase (eNOS). A positive feedback loop composed of mitochondrial Ca 2+ uptake/mROS flashes/ΔΨ m flickers and endoplasmic reticulum Ca 2+ release, in association with Piezo1 and eNOS, provided insights into the mechanism by which SS, under conditions of high MCU activity, may shape vascular EC energetics and function." @default.
- W4311576341 created "2022-12-27" @default.
- W4311576341 creator A5011101977 @default.
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- W4311576341 date "2022-12-07" @default.
- W4311576341 modified "2023-10-18" @default.
- W4311576341 title "The mitochondrial Ca2+ uniporter channel synergizes with fluid shear stress to induce mitochondrial Ca2+ oscillations" @default.
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- W4311576341 cites W1969940696 @default.
- W4311576341 cites W1970724906 @default.
- W4311576341 cites W1972071814 @default.
- W4311576341 cites W1972436525 @default.
- W4311576341 cites W1986213783 @default.
- W4311576341 cites W1988741146 @default.
- W4311576341 cites W1999257888 @default.
- W4311576341 cites W2003213503 @default.
- W4311576341 cites W2010507283 @default.
- W4311576341 cites W2016479661 @default.
- W4311576341 cites W2019618843 @default.
- W4311576341 cites W2028142112 @default.
- W4311576341 cites W2040737963 @default.
- W4311576341 cites W2048626265 @default.
- W4311576341 cites W2050659771 @default.
- W4311576341 cites W2052471341 @default.
- W4311576341 cites W2063665585 @default.
- W4311576341 cites W2067841051 @default.
- W4311576341 cites W2069013650 @default.
- W4311576341 cites W2070869619 @default.
- W4311576341 cites W2073706613 @default.
- W4311576341 cites W2080312195 @default.
- W4311576341 cites W2081369737 @default.
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- W4311576341 cites W2088017313 @default.
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- W4311576341 cites W2097097751 @default.
- W4311576341 cites W2104471136 @default.
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- W4311576341 cites W2154164520 @default.
- W4311576341 cites W2162583612 @default.
- W4311576341 cites W2165573061 @default.
- W4311576341 cites W2168385754 @default.
- W4311576341 cites W2171332611 @default.
- W4311576341 cites W2193732010 @default.
- W4311576341 cites W2199978366 @default.
- W4311576341 cites W2288233144 @default.
- W4311576341 cites W2298859645 @default.
- W4311576341 cites W2363363069 @default.
- W4311576341 cites W2500953579 @default.
- W4311576341 cites W2542750476 @default.
- W4311576341 cites W2560838048 @default.
- W4311576341 cites W2587839251 @default.
- W4311576341 cites W2590630884 @default.
- W4311576341 cites W2593744497 @default.
- W4311576341 cites W2594111041 @default.
- W4311576341 cites W2743078542 @default.
- W4311576341 cites W2745248735 @default.
- W4311576341 cites W2755900396 @default.
- W4311576341 cites W2771115522 @default.
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- W4311576341 cites W2924975078 @default.
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- W4311576341 cites W2972052582 @default.
- W4311576341 cites W3111428523 @default.
- W4311576341 cites W3112028900 @default.
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- W4311576341 doi "https://doi.org/10.1038/s41598-022-25583-7" @default.
- W4311576341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36476944" @default.
- W4311576341 hasPublicationYear "2022" @default.
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