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• W4311576346 abstract "Vasomotion is spontaneous oscillations in the diameter of resistance vessels with derived effects on blood flow, and it has been proposed that disturbances in vasomotion may be involved in retinal vascular disease. The purpose of this study was to investigate whether retinal vasomotion shows regional variation and is modified by activated autoregulation.Video recordings of the diameter of retinal arterioles previously obtained from 55 normal persons were subjected to Fourier analysis to characterize the frequencies and propagation of spontaneous diameter changes in retinal arterioles. The analyses were performed on peripapillary temporal retinal arterioles, on arteriolar branches toward the macular area and the retinal periphery, and were performed during rest, during an increase in the arterial blood pressure induced by isometric exercise, and during increased retinal metabolism induced by flickering light.There was no propagation of diameter changes along the studied vascular segments. Isometric exercise constricted the arterioles significantly by (mean ± SD) 1.76% ± 3.56% (P = 0.02) and increased the power of diameter oscillations at very low frequencies (0.1-1.4 c/min). Flicker stimulation dilated the arterioles significantly by (mean ± SD) 5.10% ± 2.91% (P < 0.0001) and reduced the power of diameter oscillations at all but the very low frequencies (P < 0.006 for all comparisons). Flicker-induced dilation and changes in hydraulic conductance were lower in peripheral than in macular arterioles.Retinal vasomotion in normal persons increases during increased arterial blood pressure and decreases during flicker stimulation. The findings may act as a basis for the study of vasomotion in retinal vascular disease." @default.
• W4311576346 created "2022-12-27" @default.
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• W4311576346 date "2022-12-07" @default.
• W4311576346 modified "2023-10-14" @default.
• W4311576346 title "Vasomotion in Retinal Arterioles Is Modified by Exercise and Flicker Stimulation" @default.
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• W4311576346 doi "https://doi.org/10.1167/iovs.63.13.7" @default.
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