FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311576463> ?p ?o ?g. }

• W4311576463 abstract "Abstract Background Lysosomes are a central hub for cellular metabolism and are involved in the regulation of cell homeostasis through the degradation or recycling of unwanted or dysfunctional organelles through the autophagy pathway. Catalase, a peroxisomal enzyme, plays an important role in cellular antioxidant defense by decomposing hydrogen peroxide into water and oxygen. In accordance with pleiotropic significance, both impaired lysosomes and catalase have been linked to many age-related pathologies with a decline in lifespan. Aging is characterized by progressive accumulation of macromolecular damage and the production of high levels of reactive oxygen species. Although lysosomes degrade the most long-lived proteins and organelles via the autophagic pathway, the role of lysosomes and their effect on catalase during aging is not known. The present study investigated the role of catalase and lysosomal function in catalase-knockout (KO) mice. Methods We performed experiments on WT and catalase KO younger (9 weeks) and mature adult (53 weeks) male mice and Mouse embryonic fibroblasts isolated from WT and KO mice from E13.5 embryos as in vivo and in ex-vivo respectively. Mouse phenotyping studies were performed with controls, and a minimum of two independent experiments were performed with more than five mice in each group. Results We found that at the age of 53 weeks (mature adult), catalase-KO mice exhibited an aging phenotype faster than wild-type (WT) mice. We also found that mature adult catalase-KO mice induced leaky lysosome by progressive accumulation of lysosomal content, such as cathespin D, into the cytosol. Leaky lysosomes inhibited autophagosome formation and triggered impaired autophagy. The dysregulation of autophagy triggered mTORC1 (mechanistic target of rapamycin complex 1) activation. However, the antioxidant N-acetyl-L-cysteine and mTORC1 inhibitor rapamycin rescued leaky lysosomes and aging phenotypes in catalase-deficient mature adult mice. Conclusions This study unveils the new role of catalase and its role in lysosomal function during aging." @default.
• W4311576463 created "2022-12-27" @default.
• W4311576463 creator A5006730796 @default.
• W4311576463 creator A5023208988 @default.
• W4311576463 creator A5040217382 @default.
• W4311576463 creator A5050853149 @default.
• W4311576463 creator A5051997417 @default.
• W4311576463 creator A5056509199 @default.
• W4311576463 creator A5063907469 @default.
• W4311576463 creator A5089614762 @default.
• W4311576463 date "2022-12-06" @default.
• W4311576463 modified "2023-10-18" @default.
• W4311576463 title "Catalase-deficient mice induce aging faster through lysosomal dysfunction" @default.
• W4311576463 cites W1499252531 @default.
• W4311576463 cites W1538904872 @default.
• W4311576463 cites W1637667857 @default.
• W4311576463 cites W1670684017 @default.
• W4311576463 cites W1813230101 @default.
• W4311576463 cites W1985820389 @default.
• W4311576463 cites W2004688803 @default.
• W4311576463 cites W2015877899 @default.
• W4311576463 cites W2023695511 @default.
• W4311576463 cites W2039035664 @default.
• W4311576463 cites W2040731722 @default.
• W4311576463 cites W2045631219 @default.
• W4311576463 cites W2048376025 @default.
• W4311576463 cites W2049230829 @default.
• W4311576463 cites W2055210668 @default.
• W4311576463 cites W2077854314 @default.
• W4311576463 cites W2087449142 @default.
• W4311576463 cites W2099864799 @default.
• W4311576463 cites W2108942016 @default.
• W4311576463 cites W2113305156 @default.
• W4311576463 cites W2114072930 @default.
• W4311576463 cites W2114108892 @default.
• W4311576463 cites W2124657712 @default.
• W4311576463 cites W2126297812 @default.
• W4311576463 cites W2150912248 @default.
• W4311576463 cites W2160279897 @default.
• W4311576463 cites W2293027573 @default.
• W4311576463 cites W2299746178 @default.
• W4311576463 cites W2344789131 @default.
• W4311576463 cites W2350256796 @default.
• W4311576463 cites W2430937405 @default.
• W4311576463 cites W2485662396 @default.
• W4311576463 cites W2525382275 @default.
• W4311576463 cites W2570688801 @default.
• W4311576463 cites W2593816418 @default.
• W4311576463 cites W2768033029 @default.
• W4311576463 cites W2774620560 @default.
• W4311576463 cites W2778881642 @default.
• W4311576463 cites W2792523396 @default.
• W4311576463 cites W2794309559 @default.
• W4311576463 cites W2810741181 @default.
• W4311576463 cites W2888292224 @default.
• W4311576463 cites W2903820573 @default.
• W4311576463 cites W2906398108 @default.
• W4311576463 cites W2913468595 @default.
• W4311576463 cites W2915141806 @default.
• W4311576463 cites W2983514836 @default.
• W4311576463 cites W3121867466 @default.
• W4311576463 cites W4225635694 @default.
• W4311576463 cites W4249893105 @default.
• W4311576463 cites W849888442 @default.
• W4311576463 doi "https://doi.org/10.1186/s12964-022-00969-2" @default.
• W4311576463 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36474295" @default.
• W4311576463 hasPublicationYear "2022" @default.
• W4311576463 type Work @default.
• W4311576463 citedByCount "6" @default.
• W4311576463 countsByYear W43115764632023 @default.
• W4311576463 crossrefType "journal-article" @default.
• W4311576463 hasAuthorship W4311576463A5006730796 @default.
• W4311576463 hasAuthorship W4311576463A5023208988 @default.
• W4311576463 hasAuthorship W4311576463A5040217382 @default.
• W4311576463 hasAuthorship W4311576463A5050853149 @default.
• W4311576463 hasAuthorship W4311576463A5051997417 @default.
• W4311576463 hasAuthorship W4311576463A5056509199 @default.
• W4311576463 hasAuthorship W4311576463A5063907469 @default.
• W4311576463 hasAuthorship W4311576463A5089614762 @default.
• W4311576463 hasBestOaLocation W43115764631 @default.
• W4311576463 hasConcept C127078168 @default.
• W4311576463 hasConcept C168240541 @default.
• W4311576463 hasConcept C170493617 @default.
• W4311576463 hasConcept C181199279 @default.
• W4311576463 hasConcept C182704531 @default.
• W4311576463 hasConcept C185592680 @default.
• W4311576463 hasConcept C190283241 @default.
• W4311576463 hasConcept C203522944 @default.
• W4311576463 hasConcept C2776151105 @default.
• W4311576463 hasConcept C2778979269 @default.
• W4311576463 hasConcept C2780216420 @default.
• W4311576463 hasConcept C48349386 @default.
• W4311576463 hasConcept C55493867 @default.
• W4311576463 hasConcept C86803240 @default.
• W4311576463 hasConcept C95444343 @default.
• W4311576463 hasConcept C98539663 @default.
• W4311576463 hasConceptScore W4311576463C127078168 @default.
• W4311576463 hasConceptScore W4311576463C168240541 @default.
• W4311576463 hasConceptScore W4311576463C170493617 @default.
• W4311576463 hasConceptScore W4311576463C181199279 @default.

• next