FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311580295> ?p ?o ?g. }

• W4311580295 endingPage "107602962211418" @default.
• W4311580295 startingPage "107602962211418" @default.
• W4311580295 abstract "ADAMTS13 cleaves von Willebrand factor (VWF) multimers into less active fragments. Both markers have been related to cardiovascular disease (CVD). We aimed to investigate the influence of ADAMTS13 single nucleotide polymorphisms (SNPs) on levels of ADAMTS13 and VWF, and CVD.The c.1342C>G, g.41635A>G and c.2699C>T polymorphisms were determined in patients with chronic coronary syndrome (n = 1000). VWF and ADAMTS13 were analyzed. Clinical endpoints after 2 years (n = 106) were unstable angina pectoris, myocardial infarction, non-hemorrhagic stroke and death.The SNPs did not affect ADAMTS13 levels. The 41635A-allele associated with higher VWF levels (P < .001). Patients with the 1342G-allele had significantly higher frequency of previous atrial fibrillation (n = 26, P = .016) and cerebral ischemic events (n = 47, P = .030). Heterozygous of the 1342CG variant experienced more clinical endpoints compared to homozygous (CC and GG) (P = .028).The association between the 41635A-allele and VWF indicates a role for this polymorphism in VWF regulation. ADAMTS13 has previously been linked to atrial fibrillation and ischemic stroke, and our findings suggest that the 1342G-allele may be of significance. The association between the 1342CG genotype and endpoints needs further investigations.Clinicaltrials.gov, ASCET, NCT00222261. https://clinicaltrials.gov/ct2/show/NCT00222261?term=NCT00222261&draw=2&rank=1." @default.
• W4311580295 created "2022-12-27" @default.
• W4311580295 creator A5025089328 @default.
• W4311580295 creator A5042571184 @default.
• W4311580295 creator A5044059350 @default.
• W4311580295 creator A5072637485 @default.
• W4311580295 creator A5078086919 @default.
• W4311580295 creator A5084461040 @default.
• W4311580295 creator A5085412635 @default.
• W4311580295 date "2022-01-01" @default.
• W4311580295 modified "2023-10-18" @default.
• W4311580295 title "Genetic Variation in ADAMTS13 is Related to VWF Levels, Atrial Fibrillation and Cerebral Ischemic Events" @default.
• W4311580295 cites W1665234907 @default.
• W4311580295 cites W1965729882 @default.
• W4311580295 cites W1967765437 @default.
• W4311580295 cites W1975147725 @default.
• W4311580295 cites W1984560146 @default.
• W4311580295 cites W2000543564 @default.
• W4311580295 cites W2008287467 @default.
• W4311580295 cites W2057751991 @default.
• W4311580295 cites W2071539899 @default.
• W4311580295 cites W2080961724 @default.
• W4311580295 cites W2100710603 @default.
• W4311580295 cites W2120163538 @default.
• W4311580295 cites W2126180059 @default.
• W4311580295 cites W2130883211 @default.
• W4311580295 cites W2140026576 @default.
• W4311580295 cites W2145622573 @default.
• W4311580295 cites W2508330584 @default.
• W4311580295 cites W2537466022 @default.
• W4311580295 cites W2550735462 @default.
• W4311580295 cites W2635609779 @default.
• W4311580295 cites W2770847095 @default.
• W4311580295 cites W2887293504 @default.
• W4311580295 cites W2922347496 @default.
• W4311580295 doi "https://doi.org/10.1177/10760296221141893" @default.
• W4311580295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36474435" @default.
• W4311580295 hasPublicationYear "2022" @default.
• W4311580295 type Work @default.
• W4311580295 citedByCount "0" @default.
• W4311580295 crossrefType "journal-article" @default.
• W4311580295 hasAuthorship W4311580295A5025089328 @default.
• W4311580295 hasAuthorship W4311580295A5042571184 @default.
• W4311580295 hasAuthorship W4311580295A5044059350 @default.
• W4311580295 hasAuthorship W4311580295A5072637485 @default.
• W4311580295 hasAuthorship W4311580295A5078086919 @default.
• W4311580295 hasAuthorship W4311580295A5084461040 @default.
• W4311580295 hasAuthorship W4311580295A5085412635 @default.
• W4311580295 hasBestOaLocation W43115802951 @default.
• W4311580295 hasConcept C104317684 @default.
• W4311580295 hasConcept C126322002 @default.
• W4311580295 hasConcept C127413603 @default.
• W4311580295 hasConcept C135763542 @default.
• W4311580295 hasConcept C153209595 @default.
• W4311580295 hasConcept C156957248 @default.
• W4311580295 hasConcept C164705383 @default.
• W4311580295 hasConcept C180754005 @default.
• W4311580295 hasConcept C2777785093 @default.
• W4311580295 hasConcept C2779161974 @default.
• W4311580295 hasConcept C2779394231 @default.
• W4311580295 hasConcept C2780645631 @default.
• W4311580295 hasConcept C2780921031 @default.
• W4311580295 hasConcept C500558357 @default.
• W4311580295 hasConcept C54355233 @default.
• W4311580295 hasConcept C71924100 @default.
• W4311580295 hasConcept C78519656 @default.
• W4311580295 hasConcept C86803240 @default.
• W4311580295 hasConcept C89560881 @default.
• W4311580295 hasConceptScore W4311580295C104317684 @default.
• W4311580295 hasConceptScore W4311580295C126322002 @default.
• W4311580295 hasConceptScore W4311580295C127413603 @default.
• W4311580295 hasConceptScore W4311580295C135763542 @default.
• W4311580295 hasConceptScore W4311580295C153209595 @default.
• W4311580295 hasConceptScore W4311580295C156957248 @default.
• W4311580295 hasConceptScore W4311580295C164705383 @default.
• W4311580295 hasConceptScore W4311580295C180754005 @default.
• W4311580295 hasConceptScore W4311580295C2777785093 @default.
• W4311580295 hasConceptScore W4311580295C2779161974 @default.
• W4311580295 hasConceptScore W4311580295C2779394231 @default.
• W4311580295 hasConceptScore W4311580295C2780645631 @default.
• W4311580295 hasConceptScore W4311580295C2780921031 @default.
• W4311580295 hasConceptScore W4311580295C500558357 @default.
• W4311580295 hasConceptScore W4311580295C54355233 @default.
• W4311580295 hasConceptScore W4311580295C71924100 @default.
• W4311580295 hasConceptScore W4311580295C78519656 @default.
• W4311580295 hasConceptScore W4311580295C86803240 @default.
• W4311580295 hasConceptScore W4311580295C89560881 @default.
• W4311580295 hasFunder F4320323299 @default.
• W4311580295 hasLocation W43115802951 @default.
• W4311580295 hasLocation W43115802952 @default.
• W4311580295 hasLocation W43115802953 @default.
• W4311580295 hasLocation W43115802954 @default.
• W4311580295 hasLocation W43115802955 @default.
• W4311580295 hasOpenAccess W4311580295 @default.
• W4311580295 hasPrimaryLocation W43115802951 @default.
• W4311580295 hasRelatedWork W118141141 @default.
• W4311580295 hasRelatedWork W1991498847 @default.
• W4311580295 hasRelatedWork W2037817991 @default.

• next