FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311580809> ?p ?o ?g. }

• W4311580809 endingPage "24S" @default.
• W4311580809 startingPage "3S" @default.
• W4311580809 abstract "Cytokines in the interleukin (IL)-23/IL-17 axis are central to psoriasis pathogenesis. Janus kinase (JAK) signal transducer and activator of transcription (STAT) regulates intracellular signalling of several cytokines (including IL-12, 23, 22, 6, 17, and interferon (IFN)-γ) in the IL-23/IL-17 axis, and, as a result, has become a therapeutic target for psoriasis treatment. Although several JAK1-3 inhibitors, with varying degrees of selectivity, have been developed for immune-mediated inflammatory diseases, use in psoriasis is limited by a low therapeutic index as anticipated by signals from other disease indications. More selective inhibition of the JAK family is an area of interest. Specifically, selective tyrosine kinase (TYK)2 inhibition suppresses IL-23/IL-17 axis signalling, and at therapeutic doses, has a favorable safety profile compared to therapeutic doses of JAK1-3 inhibitors. Phase III efficacy and safety data for the selective allosteric TYK2-inhibitor, deucravacitinib, in adult patients with moderate-to-severe plaque psoriasis is promising. Furthermore, phase II clinical trials for ropsacitinib (PF-06826647), a selective TYK2 inhibitor, and brepocitinib (PF-06700841), a JAK1/TYK2 inhibitor, have also demonstrated efficacy and an acceptable safety profile in adult patients with moderate-to-severe plaque psoriasis. Other novel TYK2 allosteric inhibitors, NDI-034858 and ESK-001, are currently being investigated in adult patients with plaque psoriasis. This article reviews the details of the JAK-STAT pathway in psoriasis pathophysiology, the rationale for selective targeting of JAKs in the treatment of psoriasis, and provides clinical perspective on clinical trial data for JAK and TYK2 inhibitors." @default.
• W4311580809 created "2022-12-27" @default.
• W4311580809 creator A5000030131 @default.
• W4311580809 creator A5006526834 @default.
• W4311580809 creator A5008286260 @default.
• W4311580809 creator A5032461308 @default.
• W4311580809 creator A5041617888 @default.
• W4311580809 creator A5056049322 @default.
• W4311580809 creator A5065570109 @default.
• W4311580809 creator A5065867182 @default.
• W4311580809 creator A5069075594 @default.
• W4311580809 creator A5081035293 @default.
• W4311580809 date "2022-12-15" @default.
• W4311580809 modified "2023-10-17" @default.
• W4311580809 title "Clinical Implications of Targeting the JAK-STAT Pathway in Psoriatic Disease: Emphasis on the TYK2 Pathway" @default.
• W4311580809 cites W1515431598 @default.
• W4311580809 cites W1671779243 @default.
• W4311580809 cites W1847326477 @default.
• W4311580809 cites W1892175722 @default.
• W4311580809 cites W1966969980 @default.
• W4311580809 cites W1977695408 @default.
• W4311580809 cites W1994127723 @default.
• W4311580809 cites W1996909138 @default.
• W4311580809 cites W2026547977 @default.
• W4311580809 cites W2030922722 @default.
• W4311580809 cites W2053423099 @default.
• W4311580809 cites W2068089617 @default.
• W4311580809 cites W2069236338 @default.
• W4311580809 cites W2074360288 @default.
• W4311580809 cites W2080090843 @default.
• W4311580809 cites W2080165152 @default.
• W4311580809 cites W2081482161 @default.
• W4311580809 cites W2107432039 @default.
• W4311580809 cites W2115234382 @default.
• W4311580809 cites W2121008892 @default.
• W4311580809 cites W2132173287 @default.
• W4311580809 cites W2138647255 @default.
• W4311580809 cites W2149889271 @default.
• W4311580809 cites W2167305078 @default.
• W4311580809 cites W2231320375 @default.
• W4311580809 cites W2283622962 @default.
• W4311580809 cites W2336100717 @default.
• W4311580809 cites W2336399478 @default.
• W4311580809 cites W2547876355 @default.
• W4311580809 cites W2593565645 @default.
• W4311580809 cites W2618122943 @default.
• W4311580809 cites W2752721387 @default.
• W4311580809 cites W2766846920 @default.
• W4311580809 cites W2767394258 @default.
• W4311580809 cites W2886980930 @default.
• W4311580809 cites W2887399354 @default.
• W4311580809 cites W2890221919 @default.
• W4311580809 cites W2892136519 @default.
• W4311580809 cites W2903436036 @default.
• W4311580809 cites W2914209107 @default.
• W4311580809 cites W2956179332 @default.
• W4311580809 cites W2961075409 @default.
• W4311580809 cites W3005096969 @default.
• W4311580809 cites W3007389533 @default.
• W4311580809 cites W3010985734 @default.
• W4311580809 cites W3017270234 @default.
• W4311580809 cites W3044651017 @default.
• W4311580809 cites W3094882380 @default.
• W4311580809 cites W3100055007 @default.
• W4311580809 cites W3109739095 @default.
• W4311580809 cites W3124339251 @default.
• W4311580809 cites W3136549884 @default.
• W4311580809 cites W3147660541 @default.
• W4311580809 cites W3152655764 @default.
• W4311580809 cites W3157423361 @default.
• W4311580809 cites W3157970781 @default.
• W4311580809 cites W3158354087 @default.
• W4311580809 cites W3164705475 @default.
• W4311580809 cites W3174212996 @default.
• W4311580809 cites W3175887127 @default.
• W4311580809 cites W3182681670 @default.
• W4311580809 cites W3187183586 @default.
• W4311580809 cites W3193648663 @default.
• W4311580809 cites W3205622799 @default.
• W4311580809 cites W3206870195 @default.
• W4311580809 cites W3209111120 @default.
• W4311580809 cites W3213252676 @default.
• W4311580809 cites W4200522151 @default.
• W4311580809 cites W4210529991 @default.
• W4311580809 cites W4211144854 @default.
• W4311580809 cites W4220744609 @default.
• W4311580809 cites W4223647933 @default.
• W4311580809 cites W4229034592 @default.
• W4311580809 cites W4295254314 @default.
• W4311580809 cites W4295255191 @default.
• W4311580809 cites W4295255295 @default.
• W4311580809 cites W4295261199 @default.
• W4311580809 cites W4309316997 @default.
• W4311580809 cites W962657022 @default.
• W4311580809 doi "https://doi.org/10.1177/12034754221141680" @default.
• W4311580809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36519621" @default.
• W4311580809 hasPublicationYear "2022" @default.
• W4311580809 type Work @default.

• next