FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311582246> ?p ?o ?g. }

• W4311582246 abstract "Methods for C-H cyanation of pyridines are rare. Here, we report a method for C3-selective cyanation of pyridines by a tandem process with the reaction of an in situ generated dihydropyridine with a cyano electrophile as the key step. The method is suitable for late-stage functionalization of pyridine drugs. The low reduction potential of the electrophile and effective transfer of the nitrile group were found to be essential for the success of this method. We studied the reaction mechanism in detail by means of control experiments and theoretical calculations and found that a combination of electronic and steric factors determined the regioselectivity of reactions involving C2-substituted pyridines." @default.
• W4311582246 created "2022-12-27" @default.
• W4311582246 creator A5027186708 @default.
• W4311582246 creator A5045782856 @default.
• W4311582246 creator A5047001057 @default.
• W4311582246 creator A5052675433 @default.
• W4311582246 creator A5061022837 @default.
• W4311582246 creator A5076315983 @default.
• W4311582246 date "2023-01-09" @default.
• W4311582246 modified "2023-10-16" @default.
• W4311582246 title "C3‐Cyanation of Pyridines: Constraints on Electrophiles and Determinants of Regioselectivity" @default.
• W4311582246 cites W1601985418 @default.
• W4311582246 cites W1607660917 @default.
• W4311582246 cites W1842093545 @default.
• W4311582246 cites W1976825482 @default.
• W4311582246 cites W1981600895 @default.
• W4311582246 cites W1983601902 @default.
• W4311582246 cites W1984963453 @default.
• W4311582246 cites W2005730386 @default.
• W4311582246 cites W2007371304 @default.
• W4311582246 cites W2019240387 @default.
• W4311582246 cites W2028669795 @default.
• W4311582246 cites W2045809294 @default.
• W4311582246 cites W2049151138 @default.
• W4311582246 cites W2049353031 @default.
• W4311582246 cites W2051999517 @default.
• W4311582246 cites W2054746493 @default.
• W4311582246 cites W2064308869 @default.
• W4311582246 cites W2080854581 @default.
• W4311582246 cites W2090082574 @default.
• W4311582246 cites W2120487279 @default.
• W4311582246 cites W2128789094 @default.
• W4311582246 cites W2149555208 @default.
• W4311582246 cites W2169663628 @default.
• W4311582246 cites W2178370092 @default.
• W4311582246 cites W2210335935 @default.
• W4311582246 cites W2284984697 @default.
• W4311582246 cites W2318067001 @default.
• W4311582246 cites W2322296010 @default.
• W4311582246 cites W2323057668 @default.
• W4311582246 cites W2325492496 @default.
• W4311582246 cites W2325652487 @default.
• W4311582246 cites W2327833037 @default.
• W4311582246 cites W2328399990 @default.
• W4311582246 cites W2407040666 @default.
• W4311582246 cites W2606187023 @default.
• W4311582246 cites W2609472088 @default.
• W4311582246 cites W2615235717 @default.
• W4311582246 cites W2726859433 @default.
• W4311582246 cites W273862411 @default.
• W4311582246 cites W2748707905 @default.
• W4311582246 cites W2763400574 @default.
• W4311582246 cites W2781768046 @default.
• W4311582246 cites W2785756486 @default.
• W4311582246 cites W2795539041 @default.
• W4311582246 cites W2899108250 @default.
• W4311582246 cites W2902974672 @default.
• W4311582246 cites W2921370692 @default.
• W4311582246 cites W2940265010 @default.
• W4311582246 cites W2949857894 @default.
• W4311582246 cites W2950116055 @default.
• W4311582246 cites W2993678285 @default.
• W4311582246 cites W3012643120 @default.
• W4311582246 cites W3030507091 @default.
• W4311582246 cites W3041770295 @default.
• W4311582246 cites W3097752778 @default.
• W4311582246 cites W3097880148 @default.
• W4311582246 cites W3099823847 @default.
• W4311582246 cites W3125143590 @default.
• W4311582246 cites W3132520955 @default.
• W4311582246 cites W3134466926 @default.
• W4311582246 cites W3157504955 @default.
• W4311582246 cites W3159395997 @default.
• W4311582246 cites W3160334326 @default.
• W4311582246 cites W3169019318 @default.
• W4311582246 cites W3190579890 @default.
• W4311582246 cites W3190990114 @default.
• W4311582246 cites W3195227379 @default.
• W4311582246 cites W3206299100 @default.
• W4311582246 cites W4210370823 @default.
• W4311582246 cites W4213310706 @default.
• W4311582246 cites W4220839320 @default.
• W4311582246 cites W4230868897 @default.
• W4311582246 cites W4243186509 @default.
• W4311582246 cites W4249155326 @default.
• W4311582246 cites W4251231619 @default.
• W4311582246 cites W4253644550 @default.
• W4311582246 cites W4289261561 @default.
• W4311582246 cites W4307976436 @default.
• W4311582246 cites W4309232851 @default.
• W4311582246 cites W4309233078 @default.
• W4311582246 doi "https://doi.org/10.1002/anie.202216894" @default.
• W4311582246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36517651" @default.
• W4311582246 hasPublicationYear "2023" @default.
• W4311582246 type Work @default.
• W4311582246 citedByCount "9" @default.
• W4311582246 countsByYear W43115822462023 @default.
• W4311582246 crossrefType "journal-article" @default.
• W4311582246 hasAuthorship W4311582246A5027186708 @default.
• W4311582246 hasAuthorship W4311582246A5045782856 @default.

• next