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- W4311583011 endingPage "2069" @default.
- W4311583011 startingPage "2049" @default.
- W4311583011 abstract "Epilepsy is defined as spontaneous recurrent seizures in the brain. There is increasing evidence that inflammatory mediators and immune cells are involved in epileptic seizures. As more research is done on inflammatory factors and immune cells in epilepsy, new targets for the treatment of epilepsy will be revealed. The Janus kinase-signal transducer and transcriptional activator (JAKSTAT) signaling pathway is strongly associated with many immune and inflammatory diseases, At present, more and more studies have found that the JAK-STAT pathway is involved in the development and development of epilepsy, indicating the JAK-STAT pathway's potential promise as a target in epilepsy treatment. In this review, we discuss the composition, activation, and regulation of the JAK-STAT pathway and the relationship between the JAK-STAT pathway and epilepsy. In addition, we summarize the common clinical inhibitors of JAK and STAT that we would expect to be used in epilepsy treatment in the future." @default.
- W4311583011 created "2022-12-27" @default.
- W4311583011 creator A5017746293 @default.
- W4311583011 creator A5021582503 @default.
- W4311583011 creator A5040815124 @default.
- W4311583011 creator A5041530257 @default.
- W4311583011 creator A5051054343 @default.
- W4311583011 creator A5069354293 @default.
- W4311583011 creator A5074075216 @default.
- W4311583011 creator A5090981127 @default.
- W4311583011 creator A5009273053 @default.
- W4311583011 date "2023-10-01" @default.
- W4311583011 modified "2023-10-12" @default.
- W4311583011 title "The JAK-STAT Signaling Pathway in Epilepsy" @default.
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