FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311584328> ?p ?o ?g. }

• W4311584328 abstract "To better understand the potential relationship between COVID-19 disease and hologenome microbial community dynamics and functional profiles, we conducted a multivariate taxonomic and functional microbiome comparison of publicly available human bronchoalveolar lavage fluid (BALF) metatranscriptome samples amongst COVID-19 (n = 32), community acquired pneumonia (CAP) (n = 25), and uninfected samples (n = 29). We then performed a stratified analysis based on mortality amongst the COVID-19 cohort with known outcomes of deceased (n = 10) versus survived (n = 15). Our overarching hypothesis was that there are detectable and functionally significant relationships between BALF microbial metatranscriptomes and the severity of COVID-19 disease onset and progression. We observed 34 functionally discriminant gene ontology (GO) terms in COVID-19 disease compared to the CAP and uninfected cohorts, and 21 GO terms functionally discriminant to COVID-19 mortality (q < 0.05). GO terms enriched in the COVID-19 disease cohort included hydrolase activity, and significant GO terms under the parental terms of biological regulation, viral process, and interspecies interaction between organisms. Notable GO terms associated with COVID-19 mortality included nucleobase-containing compound biosynthetic process, organonitrogen compound catabolic process, pyrimidine-containing compound biosynthetic process, and DNA recombination, RNA binding, magnesium and zinc ion binding, oxidoreductase activity, and endopeptidase activity. A Dirichlet multinomial mixtures clustering analysis resulted in a best model fit using three distinct clusters that were significantly associated with COVID-19 disease and mortality. We additionally observed discriminant taxonomic differences associated with COVID-19 disease and mortality in the genus Sphingomonas, belonging to the Sphingomonadacae family, Variovorax, belonging to the Comamonadaceae family, and in the class Bacteroidia, belonging to the order Bacteroidales. To our knowledge, this is the first study to evaluate significant differences in taxonomic and functional signatures between BALF metatranscriptomes from COVID-19, CAP, and uninfected cohorts, as well as associating these taxa and microbial gene functions with COVID-19 mortality. Collectively, while this data does not speak to causality nor directionality of the association, it does demonstrate a significant relationship between the human microbiome and COVID-19. The results from this study have rendered testable hypotheses that warrant further investigation to better understand the causality and directionality of host-microbiome-pathogen interactions." @default.
• W4311584328 created "2022-12-27" @default.
• W4311584328 creator A5005192870 @default.
• W4311584328 creator A5038158427 @default.
• W4311584328 creator A5053372421 @default.
• W4311584328 creator A5064937434 @default.
• W4311584328 creator A5079403333 @default.
• W4311584328 creator A5085118545 @default.
• W4311584328 creator A5086298034 @default.
• W4311584328 creator A5060119580 @default.
• W4311584328 date "2022-12-07" @default.
• W4311584328 modified "2023-09-26" @default.
• W4311584328 title "Analysis of bronchoalveolar lavage fluid metatranscriptomes among patients with COVID-19 disease" @default.
• W4311584328 cites W1995875735 @default.
• W4311584328 cites W2026338038 @default.
• W4311584328 cites W2051836984 @default.
• W4311584328 cites W2053801811 @default.
• W4311584328 cites W2056279562 @default.
• W4311584328 cites W2062211895 @default.
• W4311584328 cites W2065230640 @default.
• W4311584328 cites W2070068738 @default.
• W4311584328 cites W2087189381 @default.
• W4311584328 cites W2126709153 @default.
• W4311584328 cites W2131271579 @default.
• W4311584328 cites W2157107905 @default.
• W4311584328 cites W2166358290 @default.
• W4311584328 cites W2303015818 @default.
• W4311584328 cites W2510766756 @default.
• W4311584328 cites W2898904131 @default.
• W4311584328 cites W2898929200 @default.
• W4311584328 cites W2945265881 @default.
• W4311584328 cites W2951912016 @default.
• W4311584328 cites W2952463830 @default.
• W4311584328 cites W2981354744 @default.
• W4311584328 cites W2990618091 @default.
• W4311584328 cites W2994839185 @default.
• W4311584328 cites W3003217347 @default.
• W4311584328 cites W3004280078 @default.
• W4311584328 cites W3005510968 @default.
• W4311584328 cites W3009109635 @default.
• W4311584328 cites W3013843138 @default.
• W4311584328 cites W3016489853 @default.
• W4311584328 cites W3020256153 @default.
• W4311584328 cites W3021413551 @default.
• W4311584328 cites W3096175488 @default.
• W4311584328 cites W3111047580 @default.
• W4311584328 cites W3137652077 @default.
• W4311584328 cites W3145217779 @default.
• W4311584328 cites W3150291517 @default.
• W4311584328 cites W3163596978 @default.
• W4311584328 cites W3196235362 @default.
• W4311584328 cites W3211779138 @default.
• W4311584328 cites W3212598764 @default.
• W4311584328 cites W4205394240 @default.
• W4311584328 cites W4210600237 @default.
• W4311584328 cites W4220724265 @default.
• W4311584328 cites W4225669898 @default.
• W4311584328 cites W4283171645 @default.
• W4311584328 cites W4313365909 @default.
• W4311584328 doi "https://doi.org/10.1038/s41598-022-25463-0" @default.
• W4311584328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36476670" @default.
• W4311584328 hasPublicationYear "2022" @default.
• W4311584328 type Work @default.
• W4311584328 citedByCount "0" @default.
• W4311584328 crossrefType "journal-article" @default.
• W4311584328 hasAuthorship W4311584328A5005192870 @default.
• W4311584328 hasAuthorship W4311584328A5038158427 @default.
• W4311584328 hasAuthorship W4311584328A5053372421 @default.
• W4311584328 hasAuthorship W4311584328A5060119580 @default.
• W4311584328 hasAuthorship W4311584328A5064937434 @default.
• W4311584328 hasAuthorship W4311584328A5079403333 @default.
• W4311584328 hasAuthorship W4311584328A5085118545 @default.
• W4311584328 hasAuthorship W4311584328A5086298034 @default.
• W4311584328 hasBestOaLocation W43115843281 @default.
• W4311584328 hasConcept C126322002 @default.
• W4311584328 hasConcept C203014093 @default.
• W4311584328 hasConcept C2777714996 @default.
• W4311584328 hasConcept C2777914695 @default.
• W4311584328 hasConcept C2777961210 @default.
• W4311584328 hasConcept C2779134260 @default.
• W4311584328 hasConcept C71924100 @default.
• W4311584328 hasConcept C86803240 @default.
• W4311584328 hasConceptScore W4311584328C126322002 @default.
• W4311584328 hasConceptScore W4311584328C203014093 @default.
• W4311584328 hasConceptScore W4311584328C2777714996 @default.
• W4311584328 hasConceptScore W4311584328C2777914695 @default.
• W4311584328 hasConceptScore W4311584328C2777961210 @default.
• W4311584328 hasConceptScore W4311584328C2779134260 @default.
• W4311584328 hasConceptScore W4311584328C71924100 @default.
• W4311584328 hasConceptScore W4311584328C86803240 @default.
• W4311584328 hasFunder F4320332161 @default.
• W4311584328 hasFunder F4320333051 @default.
• W4311584328 hasFunder F4320337355 @default.
• W4311584328 hasIssue "1" @default.
• W4311584328 hasLocation W43115843281 @default.
• W4311584328 hasLocation W43115843282 @default.
• W4311584328 hasLocation W43115843283 @default.
• W4311584328 hasLocation W43115843284 @default.
• W4311584328 hasOpenAccess W4311584328 @default.
• W4311584328 hasPrimaryLocation W43115843281 @default.

• next